Reduced 25-hydroxyvitamin D concentration in the aqueous humor of cataract patients with open-angle glaucoma

Abstract Previous epidemiological studies have demonstrated that the lower serum concentration of vitamin D was associated with elevated risk of open-angle glaucoma (OAG). However, few studies have examined the association between aqueous humor vitamin D concentrations and OAG. Hence, we investigate...

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Autores principales:	Yongwun Cho, Seung Pil Yun, Woong-Sun Yoo, Rock-Bum Kim, Min-Chul Cho, Seong-Jae Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dc551e143dd044078d6575f0949e407b
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spelling	oai:doaj.org-article:dc551e143dd044078d6575f0949e407b2021-12-02T18:48:02ZReduced 25-hydroxyvitamin D concentration in the aqueous humor of cataract patients with open-angle glaucoma10.1038/s41598-021-98342-92045-2322https://doaj.org/article/dc551e143dd044078d6575f0949e407b2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98342-9https://doaj.org/toc/2045-2322Abstract Previous epidemiological studies have demonstrated that the lower serum concentration of vitamin D was associated with elevated risk of open-angle glaucoma (OAG). However, few studies have examined the association between aqueous humor vitamin D concentrations and OAG. Hence, we investigated the relationship between 25-hydroxyvitamin D (25(OH)D) concentrations in aqueous humor and OAG. We measured 25(OH)D concentrations in aqueous humor and serum of 126 patients who underwent cataract surgery. 36 were patients with OAG and 90 were control patients. The 25(OH)D concentrations were measured using Elecsys Vitamin D Total Kits with the Cobas e602 module (Roche Diagnostics, Mannheim, Germany), an electrochemiluminescence assay. Multiple linear regression analysis was performed to investigate factors associated with serum and aqueous humor 25(OH)D concentrations. Patients with OAG had significantly lower 25(OH)D concentrations in aqueous humor than control patients. Serum 25(OH)D concentrations were higher in patients with OAG than in the control, but this was not statistically significant. 25(OH)D concentrations in aqueous humor of patients with OAG were significantly associated with axial length but not with glaucoma severity, which was determined by the retinal nerve fiber layer thickness or mean deviation. Vitamin D concentrations in aqueous humor of patients with OAG were significantly lower than those in patients without OAG.Yongwun ChoSeung Pil YunWoong-Sun YooRock-Bum KimMin-Chul ChoSeong-Jae KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yongwun Cho Seung Pil Yun Woong-Sun Yoo Rock-Bum Kim Min-Chul Cho Seong-Jae Kim Reduced 25-hydroxyvitamin D concentration in the aqueous humor of cataract patients with open-angle glaucoma
description	Abstract Previous epidemiological studies have demonstrated that the lower serum concentration of vitamin D was associated with elevated risk of open-angle glaucoma (OAG). However, few studies have examined the association between aqueous humor vitamin D concentrations and OAG. Hence, we investigated the relationship between 25-hydroxyvitamin D (25(OH)D) concentrations in aqueous humor and OAG. We measured 25(OH)D concentrations in aqueous humor and serum of 126 patients who underwent cataract surgery. 36 were patients with OAG and 90 were control patients. The 25(OH)D concentrations were measured using Elecsys Vitamin D Total Kits with the Cobas e602 module (Roche Diagnostics, Mannheim, Germany), an electrochemiluminescence assay. Multiple linear regression analysis was performed to investigate factors associated with serum and aqueous humor 25(OH)D concentrations. Patients with OAG had significantly lower 25(OH)D concentrations in aqueous humor than control patients. Serum 25(OH)D concentrations were higher in patients with OAG than in the control, but this was not statistically significant. 25(OH)D concentrations in aqueous humor of patients with OAG were significantly associated with axial length but not with glaucoma severity, which was determined by the retinal nerve fiber layer thickness or mean deviation. Vitamin D concentrations in aqueous humor of patients with OAG were significantly lower than those in patients without OAG.
format	article
author	Yongwun Cho Seung Pil Yun Woong-Sun Yoo Rock-Bum Kim Min-Chul Cho Seong-Jae Kim
author_facet	Yongwun Cho Seung Pil Yun Woong-Sun Yoo Rock-Bum Kim Min-Chul Cho Seong-Jae Kim
author_sort	Yongwun Cho
title	Reduced 25-hydroxyvitamin D concentration in the aqueous humor of cataract patients with open-angle glaucoma
title_short	Reduced 25-hydroxyvitamin D concentration in the aqueous humor of cataract patients with open-angle glaucoma
title_full	Reduced 25-hydroxyvitamin D concentration in the aqueous humor of cataract patients with open-angle glaucoma
title_fullStr	Reduced 25-hydroxyvitamin D concentration in the aqueous humor of cataract patients with open-angle glaucoma
title_full_unstemmed	Reduced 25-hydroxyvitamin D concentration in the aqueous humor of cataract patients with open-angle glaucoma
title_sort	reduced 25-hydroxyvitamin d concentration in the aqueous humor of cataract patients with open-angle glaucoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dc551e143dd044078d6575f0949e407b
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Reduced 25-hydroxyvitamin D concentration in the aqueous humor of cataract patients with open-angle glaucoma

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