Evolutionary trade-offs associated with loss of PmrB function in host-adapted Pseudomonas aeruginosa

Mutations in gene pmrB are found in Pseudomonas aeruginosa isolates from cystic fibrosis patients. Here, Bricio-Moreno et al. show in a mouse model of respiratory infection that the mutations enhance bacterial adherence to epithelial cells and resistance to lysozyme, but also increase antibiotic sus...

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Autores principales:	Laura Bricio-Moreno, Victoria H. Sheridan, Ian Goodhead, Stuart Armstrong, Janet K.L. Wong, Elaine M. Waters, Joscelyn Sarsby, Stavros Panagiotou, James Dunn, Adrita Chakraborty, Yongliang Fang, Karl E. Griswold, Craig Winstanley, Joanne L. Fothergill, Aras Kadioglu, Daniel R. Neill
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dc57b3200e764343a7284314e6587068
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spelling	oai:doaj.org-article:dc57b3200e764343a7284314e65870682021-12-02T14:39:07ZEvolutionary trade-offs associated with loss of PmrB function in host-adapted Pseudomonas aeruginosa10.1038/s41467-018-04996-x2041-1723https://doaj.org/article/dc57b3200e764343a7284314e65870682018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04996-xhttps://doaj.org/toc/2041-1723Mutations in gene pmrB are found in Pseudomonas aeruginosa isolates from cystic fibrosis patients. Here, Bricio-Moreno et al. show in a mouse model of respiratory infection that the mutations enhance bacterial adherence to epithelial cells and resistance to lysozyme, but also increase antibiotic susceptibility.Laura Bricio-MorenoVictoria H. SheridanIan GoodheadStuart ArmstrongJanet K.L. WongElaine M. WatersJoscelyn SarsbyStavros PanagiotouJames DunnAdrita ChakrabortyYongliang FangKarl E. GriswoldCraig WinstanleyJoanne L. FothergillAras KadiogluDaniel R. NeillNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Laura Bricio-Moreno Victoria H. Sheridan Ian Goodhead Stuart Armstrong Janet K.L. Wong Elaine M. Waters Joscelyn Sarsby Stavros Panagiotou James Dunn Adrita Chakraborty Yongliang Fang Karl E. Griswold Craig Winstanley Joanne L. Fothergill Aras Kadioglu Daniel R. Neill Evolutionary trade-offs associated with loss of PmrB function in host-adapted Pseudomonas aeruginosa
description	Mutations in gene pmrB are found in Pseudomonas aeruginosa isolates from cystic fibrosis patients. Here, Bricio-Moreno et al. show in a mouse model of respiratory infection that the mutations enhance bacterial adherence to epithelial cells and resistance to lysozyme, but also increase antibiotic susceptibility.
format	article
author	Laura Bricio-Moreno Victoria H. Sheridan Ian Goodhead Stuart Armstrong Janet K.L. Wong Elaine M. Waters Joscelyn Sarsby Stavros Panagiotou James Dunn Adrita Chakraborty Yongliang Fang Karl E. Griswold Craig Winstanley Joanne L. Fothergill Aras Kadioglu Daniel R. Neill
author_facet	Laura Bricio-Moreno Victoria H. Sheridan Ian Goodhead Stuart Armstrong Janet K.L. Wong Elaine M. Waters Joscelyn Sarsby Stavros Panagiotou James Dunn Adrita Chakraborty Yongliang Fang Karl E. Griswold Craig Winstanley Joanne L. Fothergill Aras Kadioglu Daniel R. Neill
author_sort	Laura Bricio-Moreno
title	Evolutionary trade-offs associated with loss of PmrB function in host-adapted Pseudomonas aeruginosa
title_short	Evolutionary trade-offs associated with loss of PmrB function in host-adapted Pseudomonas aeruginosa
title_full	Evolutionary trade-offs associated with loss of PmrB function in host-adapted Pseudomonas aeruginosa
title_fullStr	Evolutionary trade-offs associated with loss of PmrB function in host-adapted Pseudomonas aeruginosa
title_full_unstemmed	Evolutionary trade-offs associated with loss of PmrB function in host-adapted Pseudomonas aeruginosa
title_sort	evolutionary trade-offs associated with loss of pmrb function in host-adapted pseudomonas aeruginosa
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/dc57b3200e764343a7284314e6587068
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Evolutionary trade-offs associated with loss of PmrB function in host-adapted Pseudomonas aeruginosa

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