Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase
The Bcr-Abl tyrosine kinases p210 and p190 are linked to different leukemias and differ by the Dbl homology (DH) and Pleckstrin-homology (PH) domains. Here the authors characterize structures of the Bcr-Abl p210 DH and PH domains and find that the PH domain is important for the cellular localization...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2017
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/dc5c32c8cdcb4768b619089187cee0d3 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:dc5c32c8cdcb4768b619089187cee0d3 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:dc5c32c8cdcb4768b619089187cee0d32021-12-02T14:41:59ZStructural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase10.1038/s41467-017-02313-62041-1723https://doaj.org/article/dc5c32c8cdcb4768b619089187cee0d32017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02313-6https://doaj.org/toc/2041-1723The Bcr-Abl tyrosine kinases p210 and p190 are linked to different leukemias and differ by the Dbl homology (DH) and Pleckstrin-homology (PH) domains. Here the authors characterize structures of the Bcr-Abl p210 DH and PH domains and find that the PH domain is important for the cellular localization and signaling network of p210.Sina ReckelCharlotte GehinDelphine TardivonSandrine GeorgeonTim KükenshönerFrank LöhrAkiko KoideLena BuchnerAlejandro PanjkovichAline ReynaudSara PinhoBarbara GerigDmitri SvergunFlorence PojerPeter GüntertVolker DötschShohei KoideAnne-Claude GavinOliver HantschelNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Sina Reckel Charlotte Gehin Delphine Tardivon Sandrine Georgeon Tim Kükenshöner Frank Löhr Akiko Koide Lena Buchner Alejandro Panjkovich Aline Reynaud Sara Pinho Barbara Gerig Dmitri Svergun Florence Pojer Peter Güntert Volker Dötsch Shohei Koide Anne-Claude Gavin Oliver Hantschel Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase |
| description |
The Bcr-Abl tyrosine kinases p210 and p190 are linked to different leukemias and differ by the Dbl homology (DH) and Pleckstrin-homology (PH) domains. Here the authors characterize structures of the Bcr-Abl p210 DH and PH domains and find that the PH domain is important for the cellular localization and signaling network of p210. |
| format |
article |
| author |
Sina Reckel Charlotte Gehin Delphine Tardivon Sandrine Georgeon Tim Kükenshöner Frank Löhr Akiko Koide Lena Buchner Alejandro Panjkovich Aline Reynaud Sara Pinho Barbara Gerig Dmitri Svergun Florence Pojer Peter Güntert Volker Dötsch Shohei Koide Anne-Claude Gavin Oliver Hantschel |
| author_facet |
Sina Reckel Charlotte Gehin Delphine Tardivon Sandrine Georgeon Tim Kükenshöner Frank Löhr Akiko Koide Lena Buchner Alejandro Panjkovich Aline Reynaud Sara Pinho Barbara Gerig Dmitri Svergun Florence Pojer Peter Güntert Volker Dötsch Shohei Koide Anne-Claude Gavin Oliver Hantschel |
| author_sort |
Sina Reckel |
| title |
Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase |
| title_short |
Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase |
| title_full |
Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase |
| title_fullStr |
Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase |
| title_full_unstemmed |
Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase |
| title_sort |
structural and functional dissection of the dh and ph domains of oncogenic bcr-abl tyrosine kinase |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/dc5c32c8cdcb4768b619089187cee0d3 |
| work_keys_str_mv |
AT sinareckel structuralandfunctionaldissectionofthedhandphdomainsofoncogenicbcrabltyrosinekinase AT charlottegehin structuralandfunctionaldissectionofthedhandphdomainsofoncogenicbcrabltyrosinekinase AT delphinetardivon structuralandfunctionaldissectionofthedhandphdomainsofoncogenicbcrabltyrosinekinase AT sandrinegeorgeon structuralandfunctionaldissectionofthedhandphdomainsofoncogenicbcrabltyrosinekinase AT timkukenshoner structuralandfunctionaldissectionofthedhandphdomainsofoncogenicbcrabltyrosinekinase AT franklohr structuralandfunctionaldissectionofthedhandphdomainsofoncogenicbcrabltyrosinekinase AT akikokoide structuralandfunctionaldissectionofthedhandphdomainsofoncogenicbcrabltyrosinekinase AT lenabuchner structuralandfunctionaldissectionofthedhandphdomainsofoncogenicbcrabltyrosinekinase AT alejandropanjkovich structuralandfunctionaldissectionofthedhandphdomainsofoncogenicbcrabltyrosinekinase AT alinereynaud structuralandfunctionaldissectionofthedhandphdomainsofoncogenicbcrabltyrosinekinase AT sarapinho structuralandfunctionaldissectionofthedhandphdomainsofoncogenicbcrabltyrosinekinase AT barbaragerig structuralandfunctionaldissectionofthedhandphdomainsofoncogenicbcrabltyrosinekinase AT dmitrisvergun structuralandfunctionaldissectionofthedhandphdomainsofoncogenicbcrabltyrosinekinase AT florencepojer structuralandfunctionaldissectionofthedhandphdomainsofoncogenicbcrabltyrosinekinase AT peterguntert structuralandfunctionaldissectionofthedhandphdomainsofoncogenicbcrabltyrosinekinase AT volkerdotsch structuralandfunctionaldissectionofthedhandphdomainsofoncogenicbcrabltyrosinekinase AT shoheikoide structuralandfunctionaldissectionofthedhandphdomainsofoncogenicbcrabltyrosinekinase AT anneclaudegavin structuralandfunctionaldissectionofthedhandphdomainsofoncogenicbcrabltyrosinekinase AT oliverhantschel structuralandfunctionaldissectionofthedhandphdomainsofoncogenicbcrabltyrosinekinase |
| _version_ |
1718389840408477696 |