A comparison of traditional diarrhoea measurement methods with microbiological and biochemical indicators: A cross-sectional observational study in the Cox's Bazar displaced persons camp

Background: Water, Sanitation, and Hygiene (WASH) systems aim to reduce the spread of enteric pathogens, particularly amongst children under five years old. The most common primary outcome of WASH trials is carer-reported diarrhoea. We evaluate different diarrhoea survey instruments as proxy markers...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ryan Rego, Samuel Watson, Mohammad Atique Ul Alam, Syed Asif Abdullah, Mohammad Yunus, Imam Taskin Alam, A.S.M.Homuan Kabir Chowdhury, S.M.Arefeen Haider, ASG Faruque, Azharul Islam Khan, Timothy Hofer, Paramjit Gill, Mohammad Sirajul Islam, Richard Lilford
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Diarrhoea Diagnostics Refugee Enteric Infection Epidemiology Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/dc5f915f3fc14080911c75beb476b814
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:dc5f915f3fc14080911c75beb476b814
record_format	dspace
spelling	oai:doaj.org-article:dc5f915f3fc14080911c75beb476b8142021-11-22T04:29:00ZA comparison of traditional diarrhoea measurement methods with microbiological and biochemical indicators: A cross-sectional observational study in the Cox's Bazar displaced persons camp2589-537010.1016/j.eclinm.2021.101205https://doaj.org/article/dc5f915f3fc14080911c75beb476b8142021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589537021004867https://doaj.org/toc/2589-5370Background: Water, Sanitation, and Hygiene (WASH) systems aim to reduce the spread of enteric pathogens, particularly amongst children under five years old. The most common primary outcome of WASH trials is carer-reported diarrhoea. We evaluate different diarrhoea survey instruments as proxy markers of enteric pathogen presence in stool. Methods: We recruited 800 community-based participants from the Cox's Bazar Displaced Person's Camp in Bangladesh, split evenly between the rainy (July/August 2020) and dry (November/December 2020) periods. Participants were randomized evenly into either a standard survey asking carers if their child under five years old has had diarrhoea in the past fortnight, or a pictorial survey asking carers to pick from a pictorial chart which stools their child under five years old has had in the past fortnight. We collected stools from a random sub-sample of 120. Stools were examined visually, and tested for proteins associated with enteric infection and 16 enteric pathogens. We calculated sensitivities and specificities for each survey type, visual examination, and proteins with respect to enteric pathogen presence. Findings: The sensitivity of the standard survey for enteric pathogen presence was 0.49[95%CI:0.32,0.66] and the specificity was 0.65[0.41,0.85]. Similar sensitivities and specificities were observed for pictorial survey, visual inspection, and proteins. Interpretation: While diarrhoea is an important sign in clinical practice it appears that it is a poor proxy for enteric pathogen presence in stool in epidemiological surveys. When enteric infection is of interest, this should be measured directly. Funding: The project was funded by the National Institutes for Health Research Global Health Research Unit on Improving Health in Slums (16/136/87) and by the University of Warwick.Ryan RegoSamuel WatsonMohammad Atique Ul AlamSyed Asif AbdullahMohammad YunusImam Taskin AlamA.S.M.Homuan Kabir ChowdhuryS.M.Arefeen HaiderASG FaruqueAzharul Islam KhanTimothy HoferParamjit GillMohammad Sirajul IslamRichard LilfordElsevierarticleDiarrhoeaDiagnosticsRefugeeEntericInfectionEpidemiologyMedicine (General)R5-920ENEClinicalMedicine, Vol 42, Iss , Pp 101205- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diarrhoea Diagnostics Refugee Enteric Infection Epidemiology Medicine (General) R5-920
spellingShingle	Diarrhoea Diagnostics Refugee Enteric Infection Epidemiology Medicine (General) R5-920 Ryan Rego Samuel Watson Mohammad Atique Ul Alam Syed Asif Abdullah Mohammad Yunus Imam Taskin Alam A.S.M.Homuan Kabir Chowdhury S.M.Arefeen Haider ASG Faruque Azharul Islam Khan Timothy Hofer Paramjit Gill Mohammad Sirajul Islam Richard Lilford A comparison of traditional diarrhoea measurement methods with microbiological and biochemical indicators: A cross-sectional observational study in the Cox's Bazar displaced persons camp
description	Background: Water, Sanitation, and Hygiene (WASH) systems aim to reduce the spread of enteric pathogens, particularly amongst children under five years old. The most common primary outcome of WASH trials is carer-reported diarrhoea. We evaluate different diarrhoea survey instruments as proxy markers of enteric pathogen presence in stool. Methods: We recruited 800 community-based participants from the Cox's Bazar Displaced Person's Camp in Bangladesh, split evenly between the rainy (July/August 2020) and dry (November/December 2020) periods. Participants were randomized evenly into either a standard survey asking carers if their child under five years old has had diarrhoea in the past fortnight, or a pictorial survey asking carers to pick from a pictorial chart which stools their child under five years old has had in the past fortnight. We collected stools from a random sub-sample of 120. Stools were examined visually, and tested for proteins associated with enteric infection and 16 enteric pathogens. We calculated sensitivities and specificities for each survey type, visual examination, and proteins with respect to enteric pathogen presence. Findings: The sensitivity of the standard survey for enteric pathogen presence was 0.49[95%CI:0.32,0.66] and the specificity was 0.65[0.41,0.85]. Similar sensitivities and specificities were observed for pictorial survey, visual inspection, and proteins. Interpretation: While diarrhoea is an important sign in clinical practice it appears that it is a poor proxy for enteric pathogen presence in stool in epidemiological surveys. When enteric infection is of interest, this should be measured directly. Funding: The project was funded by the National Institutes for Health Research Global Health Research Unit on Improving Health in Slums (16/136/87) and by the University of Warwick.
format	article
author	Ryan Rego Samuel Watson Mohammad Atique Ul Alam Syed Asif Abdullah Mohammad Yunus Imam Taskin Alam A.S.M.Homuan Kabir Chowdhury S.M.Arefeen Haider ASG Faruque Azharul Islam Khan Timothy Hofer Paramjit Gill Mohammad Sirajul Islam Richard Lilford
author_facet	Ryan Rego Samuel Watson Mohammad Atique Ul Alam Syed Asif Abdullah Mohammad Yunus Imam Taskin Alam A.S.M.Homuan Kabir Chowdhury S.M.Arefeen Haider ASG Faruque Azharul Islam Khan Timothy Hofer Paramjit Gill Mohammad Sirajul Islam Richard Lilford
author_sort	Ryan Rego
title	A comparison of traditional diarrhoea measurement methods with microbiological and biochemical indicators: A cross-sectional observational study in the Cox's Bazar displaced persons camp
title_short	A comparison of traditional diarrhoea measurement methods with microbiological and biochemical indicators: A cross-sectional observational study in the Cox's Bazar displaced persons camp
title_full	A comparison of traditional diarrhoea measurement methods with microbiological and biochemical indicators: A cross-sectional observational study in the Cox's Bazar displaced persons camp
title_fullStr	A comparison of traditional diarrhoea measurement methods with microbiological and biochemical indicators: A cross-sectional observational study in the Cox's Bazar displaced persons camp
title_full_unstemmed	A comparison of traditional diarrhoea measurement methods with microbiological and biochemical indicators: A cross-sectional observational study in the Cox's Bazar displaced persons camp
title_sort	comparison of traditional diarrhoea measurement methods with microbiological and biochemical indicators: a cross-sectional observational study in the cox's bazar displaced persons camp
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/dc5f915f3fc14080911c75beb476b814
work_keys_str_mv	AT ryanrego acomparisonoftraditionaldiarrhoeameasurementmethodswithmicrobiologicalandbiochemicalindicatorsacrosssectionalobservationalstudyinthecoxsbazardisplacedpersonscamp AT samuelwatson acomparisonoftraditionaldiarrhoeameasurementmethodswithmicrobiologicalandbiochemicalindicatorsacrosssectionalobservationalstudyinthecoxsbazardisplacedpersonscamp AT mohammadatiqueulalam acomparisonoftraditionaldiarrhoeameasurementmethodswithmicrobiologicalandbiochemicalindicatorsacrosssectionalobservationalstudyinthecoxsbazardisplacedpersonscamp AT syedasifabdullah acomparisonoftraditionaldiarrhoeameasurementmethodswithmicrobiologicalandbiochemicalindicatorsacrosssectionalobservationalstudyinthecoxsbazardisplacedpersonscamp AT mohammadyunus acomparisonoftraditionaldiarrhoeameasurementmethodswithmicrobiologicalandbiochemicalindicatorsacrosssectionalobservationalstudyinthecoxsbazardisplacedpersonscamp AT imamtaskinalam acomparisonoftraditionaldiarrhoeameasurementmethodswithmicrobiologicalandbiochemicalindicatorsacrosssectionalobservationalstudyinthecoxsbazardisplacedpersonscamp AT asmhomuankabirchowdhury acomparisonoftraditionaldiarrhoeameasurementmethodswithmicrobiologicalandbiochemicalindicatorsacrosssectionalobservationalstudyinthecoxsbazardisplacedpersonscamp AT smarefeenhaider acomparisonoftraditionaldiarrhoeameasurementmethodswithmicrobiologicalandbiochemicalindicatorsacrosssectionalobservationalstudyinthecoxsbazardisplacedpersonscamp AT asgfaruque acomparisonoftraditionaldiarrhoeameasurementmethodswithmicrobiologicalandbiochemicalindicatorsacrosssectionalobservationalstudyinthecoxsbazardisplacedpersonscamp AT azharulislamkhan acomparisonoftraditionaldiarrhoeameasurementmethodswithmicrobiologicalandbiochemicalindicatorsacrosssectionalobservationalstudyinthecoxsbazardisplacedpersonscamp AT timothyhofer acomparisonoftraditionaldiarrhoeameasurementmethodswithmicrobiologicalandbiochemicalindicatorsacrosssectionalobservationalstudyinthecoxsbazardisplacedpersonscamp AT paramjitgill acomparisonoftraditionaldiarrhoeameasurementmethodswithmicrobiologicalandbiochemicalindicatorsacrosssectionalobservationalstudyinthecoxsbazardisplacedpersonscamp AT mohammadsirajulislam acomparisonoftraditionaldiarrhoeameasurementmethodswithmicrobiologicalandbiochemicalindicatorsacrosssectionalobservationalstudyinthecoxsbazardisplacedpersonscamp AT richardlilford acomparisonoftraditionaldiarrhoeameasurementmethodswithmicrobiologicalandbiochemicalindicatorsacrosssectionalobservationalstudyinthecoxsbazardisplacedpersonscamp AT ryanrego comparisonoftraditionaldiarrhoeameasurementmethodswithmicrobiologicalandbiochemicalindicatorsacrosssectionalobservationalstudyinthecoxsbazardisplacedpersonscamp AT samuelwatson comparisonoftraditionaldiarrhoeameasurementmethodswithmicrobiologicalandbiochemicalindicatorsacrosssectionalobservationalstudyinthecoxsbazardisplacedpersonscamp AT mohammadatiqueulalam comparisonoftraditionaldiarrhoeameasurementmethodswithmicrobiologicalandbiochemicalindicatorsacrosssectionalobservationalstudyinthecoxsbazardisplacedpersonscamp AT syedasifabdullah comparisonoftraditionaldiarrhoeameasurementmethodswithmicrobiologicalandbiochemicalindicatorsacrosssectionalobservationalstudyinthecoxsbazardisplacedpersonscamp AT mohammadyunus comparisonoftraditionaldiarrhoeameasurementmethodswithmicrobiologicalandbiochemicalindicatorsacrosssectionalobservationalstudyinthecoxsbazardisplacedpersonscamp AT imamtaskinalam comparisonoftraditionaldiarrhoeameasurementmethodswithmicrobiologicalandbiochemicalindicatorsacrosssectionalobservationalstudyinthecoxsbazardisplacedpersonscamp AT asmhomuankabirchowdhury comparisonoftraditionaldiarrhoeameasurementmethodswithmicrobiologicalandbiochemicalindicatorsacrosssectionalobservationalstudyinthecoxsbazardisplacedpersonscamp AT smarefeenhaider comparisonoftraditionaldiarrhoeameasurementmethodswithmicrobiologicalandbiochemicalindicatorsacrosssectionalobservationalstudyinthecoxsbazardisplacedpersonscamp AT asgfaruque comparisonoftraditionaldiarrhoeameasurementmethodswithmicrobiologicalandbiochemicalindicatorsacrosssectionalobservationalstudyinthecoxsbazardisplacedpersonscamp AT azharulislamkhan comparisonoftraditionaldiarrhoeameasurementmethodswithmicrobiologicalandbiochemicalindicatorsacrosssectionalobservationalstudyinthecoxsbazardisplacedpersonscamp AT timothyhofer comparisonoftraditionaldiarrhoeameasurementmethodswithmicrobiologicalandbiochemicalindicatorsacrosssectionalobservationalstudyinthecoxsbazardisplacedpersonscamp AT paramjitgill comparisonoftraditionaldiarrhoeameasurementmethodswithmicrobiologicalandbiochemicalindicatorsacrosssectionalobservationalstudyinthecoxsbazardisplacedpersonscamp AT mohammadsirajulislam comparisonoftraditionaldiarrhoeameasurementmethodswithmicrobiologicalandbiochemicalindicatorsacrosssectionalobservationalstudyinthecoxsbazardisplacedpersonscamp AT richardlilford comparisonoftraditionaldiarrhoeameasurementmethodswithmicrobiologicalandbiochemicalindicatorsacrosssectionalobservationalstudyinthecoxsbazardisplacedpersonscamp
_version_	1718418191606087680

A comparison of traditional diarrhoea measurement methods with microbiological and biochemical indicators: A cross-sectional observational study in the Cox's Bazar displaced persons camp

Ejemplares similares