Geographical influences on thyroid abnormalities in adult population from iodine-replete regions: a cross-sectional study

Abstract The studies on the increasing incidence of thyroid abnormalities are scarce. The aim of this current study was to ascertain the effects of geographical region on thyroid abnormalities under the context of universal salt iodization (USI). We randomly selected 1255 participants residing in in...

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Autores principales:	Xiaofeng Wang, Zhe Mo, Guangming Mao, Wenming Zhu, Mingluan Xing, Xueqing Li, Yuanyang Wang, Zhifang Wang, Xiaoming Lou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dc6a0dd2e1dc495aabd13c45a8371c76
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spelling	oai:doaj.org-article:dc6a0dd2e1dc495aabd13c45a8371c762021-12-02T15:23:07ZGeographical influences on thyroid abnormalities in adult population from iodine-replete regions: a cross-sectional study10.1038/s41598-020-80248-72045-2322https://doaj.org/article/dc6a0dd2e1dc495aabd13c45a8371c762021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80248-7https://doaj.org/toc/2045-2322Abstract The studies on the increasing incidence of thyroid abnormalities are scarce. The aim of this current study was to ascertain the effects of geographical region on thyroid abnormalities under the context of universal salt iodization (USI). We randomly selected 1255 participants residing in inland and 1248 in coast, with the determination of urinary iodine concentration (UIC) and functional and morphological abnormalities of thyroid gland. The median UIC was significantly higher for the inland participants (188.5 μg/L) than the coastal participants (128.5 μg/L; p < 0.001), indicating iodine sufficiency in both populations according to the recommended assessment criteria by the World Health Organization. However, the spectrum of thyroid abnormalities varied between regions, with hypothyroidism prevalent in inland and thyroid nodules in coast. The associations between region and thyroid abnormalities via binary logistic regression models showed that the coastal participants were at a higher risk of total thyroid abnormalities than those from the inland (OR 1.216, 95% CI 1.020–1.449), after the adjustment of ten confounders (demographical characteristics, smoking status, metabolism syndrome, and hyperuricemia). These results indicated that further investigations of the adverse effects of hypothyroidism and thyroid nodules on health burden is urgently needed to sustain USI program.Xiaofeng WangZhe MoGuangming MaoWenming ZhuMingluan XingXueqing LiYuanyang WangZhifang WangXiaoming LouNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiaofeng Wang Zhe Mo Guangming Mao Wenming Zhu Mingluan Xing Xueqing Li Yuanyang Wang Zhifang Wang Xiaoming Lou Geographical influences on thyroid abnormalities in adult population from iodine-replete regions: a cross-sectional study
description	Abstract The studies on the increasing incidence of thyroid abnormalities are scarce. The aim of this current study was to ascertain the effects of geographical region on thyroid abnormalities under the context of universal salt iodization (USI). We randomly selected 1255 participants residing in inland and 1248 in coast, with the determination of urinary iodine concentration (UIC) and functional and morphological abnormalities of thyroid gland. The median UIC was significantly higher for the inland participants (188.5 μg/L) than the coastal participants (128.5 μg/L; p < 0.001), indicating iodine sufficiency in both populations according to the recommended assessment criteria by the World Health Organization. However, the spectrum of thyroid abnormalities varied between regions, with hypothyroidism prevalent in inland and thyroid nodules in coast. The associations between region and thyroid abnormalities via binary logistic regression models showed that the coastal participants were at a higher risk of total thyroid abnormalities than those from the inland (OR 1.216, 95% CI 1.020–1.449), after the adjustment of ten confounders (demographical characteristics, smoking status, metabolism syndrome, and hyperuricemia). These results indicated that further investigations of the adverse effects of hypothyroidism and thyroid nodules on health burden is urgently needed to sustain USI program.
format	article
author	Xiaofeng Wang Zhe Mo Guangming Mao Wenming Zhu Mingluan Xing Xueqing Li Yuanyang Wang Zhifang Wang Xiaoming Lou
author_facet	Xiaofeng Wang Zhe Mo Guangming Mao Wenming Zhu Mingluan Xing Xueqing Li Yuanyang Wang Zhifang Wang Xiaoming Lou
author_sort	Xiaofeng Wang
title	Geographical influences on thyroid abnormalities in adult population from iodine-replete regions: a cross-sectional study
title_short	Geographical influences on thyroid abnormalities in adult population from iodine-replete regions: a cross-sectional study
title_full	Geographical influences on thyroid abnormalities in adult population from iodine-replete regions: a cross-sectional study
title_fullStr	Geographical influences on thyroid abnormalities in adult population from iodine-replete regions: a cross-sectional study
title_full_unstemmed	Geographical influences on thyroid abnormalities in adult population from iodine-replete regions: a cross-sectional study
title_sort	geographical influences on thyroid abnormalities in adult population from iodine-replete regions: a cross-sectional study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dc6a0dd2e1dc495aabd13c45a8371c76
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Geographical influences on thyroid abnormalities in adult population from iodine-replete regions: a cross-sectional study

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