Influence of age on sperm characteristics evaluated by light and electron microscopies

Abstract The impact of male aging on male fertility has only recently become of interest to the scientific community. This study aims to assess the relationship between age and fertility among a sample of men, considering the individual and pathological characteristics. In this retrospective study d...

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Autores principales:	Giulia Collodel, Fabio Ferretti, Maurizio Masini, Giacomo Gualtieri, Elena Moretti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dc6ba27387a84768958f0a11762d9e07
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spelling	oai:doaj.org-article:dc6ba27387a84768958f0a11762d9e072021-12-02T11:35:52ZInfluence of age on sperm characteristics evaluated by light and electron microscopies10.1038/s41598-021-84051-w2045-2322https://doaj.org/article/dc6ba27387a84768958f0a11762d9e072021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84051-whttps://doaj.org/toc/2045-2322Abstract The impact of male aging on male fertility has only recently become of interest to the scientific community. This study aims to assess the relationship between age and fertility among a sample of men, considering the individual and pathological characteristics. In this retrospective study data of semen analysis and medical history of 1294 Italian male patients were considered. Semen analysis was performed by light microscopy and transmission electron microscopy mathematically elaborated. A generalized linear model was used to explore the influence of male age on semen quality, considering as confounders wine consumption, smoking habits, presence of varicocele, consanguinity and positive semen bacteriological analysis and urethral swab. The mean age of the participants was 36.41 ± 6.379. Male aging without impact of confounders was correlated with a decrease in sperm concentration and motility and an increased in sperm necrosis. Sperm concentration and progressive motility were negatively related to the presence of confounders as wine consumption (sperm motility), urogenital infection (sperm concentration and motility), varicocele (sperm concentration) and consanguinity (sperm motility). Urogenital infection, varicocele and consanguinity positively correlated with sperm necrosis. The most important finding was the observation of a negative effect of male aging on sperm parameters such as concentration, motility, and viability. It is possible to hypothesize age-dependent changes of testicular environment, probably related to reactive oxygen species production. The demonstration, in a large sample of patients, that aging influences sperm quality strongly motivates further research focused on the mechanisms involved in this phenomenon and its effects on offspring fitness.Giulia CollodelFabio FerrettiMaurizio MasiniGiacomo GualtieriElena MorettiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Giulia Collodel Fabio Ferretti Maurizio Masini Giacomo Gualtieri Elena Moretti Influence of age on sperm characteristics evaluated by light and electron microscopies
description	Abstract The impact of male aging on male fertility has only recently become of interest to the scientific community. This study aims to assess the relationship between age and fertility among a sample of men, considering the individual and pathological characteristics. In this retrospective study data of semen analysis and medical history of 1294 Italian male patients were considered. Semen analysis was performed by light microscopy and transmission electron microscopy mathematically elaborated. A generalized linear model was used to explore the influence of male age on semen quality, considering as confounders wine consumption, smoking habits, presence of varicocele, consanguinity and positive semen bacteriological analysis and urethral swab. The mean age of the participants was 36.41 ± 6.379. Male aging without impact of confounders was correlated with a decrease in sperm concentration and motility and an increased in sperm necrosis. Sperm concentration and progressive motility were negatively related to the presence of confounders as wine consumption (sperm motility), urogenital infection (sperm concentration and motility), varicocele (sperm concentration) and consanguinity (sperm motility). Urogenital infection, varicocele and consanguinity positively correlated with sperm necrosis. The most important finding was the observation of a negative effect of male aging on sperm parameters such as concentration, motility, and viability. It is possible to hypothesize age-dependent changes of testicular environment, probably related to reactive oxygen species production. The demonstration, in a large sample of patients, that aging influences sperm quality strongly motivates further research focused on the mechanisms involved in this phenomenon and its effects on offspring fitness.
format	article
author	Giulia Collodel Fabio Ferretti Maurizio Masini Giacomo Gualtieri Elena Moretti
author_facet	Giulia Collodel Fabio Ferretti Maurizio Masini Giacomo Gualtieri Elena Moretti
author_sort	Giulia Collodel
title	Influence of age on sperm characteristics evaluated by light and electron microscopies
title_short	Influence of age on sperm characteristics evaluated by light and electron microscopies
title_full	Influence of age on sperm characteristics evaluated by light and electron microscopies
title_fullStr	Influence of age on sperm characteristics evaluated by light and electron microscopies
title_full_unstemmed	Influence of age on sperm characteristics evaluated by light and electron microscopies
title_sort	influence of age on sperm characteristics evaluated by light and electron microscopies
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dc6ba27387a84768958f0a11762d9e07
work_keys_str_mv	AT giuliacollodel influenceofageonspermcharacteristicsevaluatedbylightandelectronmicroscopies AT fabioferretti influenceofageonspermcharacteristicsevaluatedbylightandelectronmicroscopies AT mauriziomasini influenceofageonspermcharacteristicsevaluatedbylightandelectronmicroscopies AT giacomogualtieri influenceofageonspermcharacteristicsevaluatedbylightandelectronmicroscopies AT elenamoretti influenceofageonspermcharacteristicsevaluatedbylightandelectronmicroscopies
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Influence of age on sperm characteristics evaluated by light and electron microscopies

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