Constitutive β-catenin signaling by the viral chemokine receptor US28.
Chronic activation of Wnt/β-catenin signaling is found in a variety of human malignancies including melanoma, colorectal and hepatocellular carcinomas. Interestingly, expression of the HCMV-encoded chemokine receptor US28 in intestinal epithelial cells promotes intestinal neoplasia in transgenic mic...
Guardado en:
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2012
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/dc6c07a9a5084249b47881e5dc3e6aaf |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:dc6c07a9a5084249b47881e5dc3e6aaf |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:dc6c07a9a5084249b47881e5dc3e6aaf2021-11-18T08:09:24ZConstitutive β-catenin signaling by the viral chemokine receptor US28.1932-620310.1371/journal.pone.0048935https://doaj.org/article/dc6c07a9a5084249b47881e5dc3e6aaf2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23145028/?tool=EBIhttps://doaj.org/toc/1932-6203Chronic activation of Wnt/β-catenin signaling is found in a variety of human malignancies including melanoma, colorectal and hepatocellular carcinomas. Interestingly, expression of the HCMV-encoded chemokine receptor US28 in intestinal epithelial cells promotes intestinal neoplasia in transgenic mice, which is associated with increased nuclear accumulation of β-catenin. In this study we show that this viral receptor constitutively activates β-catenin and enhances β-catenin-dependent transcription. Our data illustrate that this viral receptor does not activate β-catenin via the classical Wnt/Frizzled signaling pathway. Analysis of US28 mediated signaling indicates the involvement of the Rho-Rho kinase (ROCK) pathway in the activation of β-catenin. Moreover, cells infected with HCMV show significant increases in β-catenin stabilization and signaling, which is mediated to a large extent by expression of US28. The modulation of the β-catenin signal transduction pathway by a viral chemokine receptor provides alternative regulation of this pathway, with potential relevance for the development of colon cancer and virus-associated diseases.Ellen V LangemeijerErik SlingerSabrina de MunnikAndreas SchreiberDavid MaussangHenry VischerFolkert VerkaarRob LeursMarco SideriusMartine J SmitPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e48935 (2012) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Ellen V Langemeijer Erik Slinger Sabrina de Munnik Andreas Schreiber David Maussang Henry Vischer Folkert Verkaar Rob Leurs Marco Siderius Martine J Smit Constitutive β-catenin signaling by the viral chemokine receptor US28. |
| description |
Chronic activation of Wnt/β-catenin signaling is found in a variety of human malignancies including melanoma, colorectal and hepatocellular carcinomas. Interestingly, expression of the HCMV-encoded chemokine receptor US28 in intestinal epithelial cells promotes intestinal neoplasia in transgenic mice, which is associated with increased nuclear accumulation of β-catenin. In this study we show that this viral receptor constitutively activates β-catenin and enhances β-catenin-dependent transcription. Our data illustrate that this viral receptor does not activate β-catenin via the classical Wnt/Frizzled signaling pathway. Analysis of US28 mediated signaling indicates the involvement of the Rho-Rho kinase (ROCK) pathway in the activation of β-catenin. Moreover, cells infected with HCMV show significant increases in β-catenin stabilization and signaling, which is mediated to a large extent by expression of US28. The modulation of the β-catenin signal transduction pathway by a viral chemokine receptor provides alternative regulation of this pathway, with potential relevance for the development of colon cancer and virus-associated diseases. |
| format |
article |
| author |
Ellen V Langemeijer Erik Slinger Sabrina de Munnik Andreas Schreiber David Maussang Henry Vischer Folkert Verkaar Rob Leurs Marco Siderius Martine J Smit |
| author_facet |
Ellen V Langemeijer Erik Slinger Sabrina de Munnik Andreas Schreiber David Maussang Henry Vischer Folkert Verkaar Rob Leurs Marco Siderius Martine J Smit |
| author_sort |
Ellen V Langemeijer |
| title |
Constitutive β-catenin signaling by the viral chemokine receptor US28. |
| title_short |
Constitutive β-catenin signaling by the viral chemokine receptor US28. |
| title_full |
Constitutive β-catenin signaling by the viral chemokine receptor US28. |
| title_fullStr |
Constitutive β-catenin signaling by the viral chemokine receptor US28. |
| title_full_unstemmed |
Constitutive β-catenin signaling by the viral chemokine receptor US28. |
| title_sort |
constitutive β-catenin signaling by the viral chemokine receptor us28. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2012 |
| url |
https://doaj.org/article/dc6c07a9a5084249b47881e5dc3e6aaf |
| work_keys_str_mv |
AT ellenvlangemeijer constitutivebcateninsignalingbytheviralchemokinereceptorus28 AT erikslinger constitutivebcateninsignalingbytheviralchemokinereceptorus28 AT sabrinademunnik constitutivebcateninsignalingbytheviralchemokinereceptorus28 AT andreasschreiber constitutivebcateninsignalingbytheviralchemokinereceptorus28 AT davidmaussang constitutivebcateninsignalingbytheviralchemokinereceptorus28 AT henryvischer constitutivebcateninsignalingbytheviralchemokinereceptorus28 AT folkertverkaar constitutivebcateninsignalingbytheviralchemokinereceptorus28 AT robleurs constitutivebcateninsignalingbytheviralchemokinereceptorus28 AT marcosiderius constitutivebcateninsignalingbytheviralchemokinereceptorus28 AT martinejsmit constitutivebcateninsignalingbytheviralchemokinereceptorus28 |
| _version_ |
1718422140177350656 |