Association between dynamic resting-state functional connectivity and ketamine plasma levels in visual processing networks

Abstract Numerous studies demonstrate ketamine’s influence on resting-state functional connectivity (rsFC). Seed-based and static rsFC estimation methods may oversimplify FC. These limitations can be addressed with whole-brain, dynamic rsFC estimation methods. We assessed data from 27 healthy subjec...

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Autores principales:	Marie Spies, Manfred Klöbl, Anna Höflich, Allan Hummer, Thomas Vanicek, Paul Michenthaler, Georg S. Kranz, Andreas Hahn, Dietmar Winkler, Christian Windischberger, Siegfried Kasper, Rupert Lanzenberger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dc6ca1232e844b7e87ff334666da85ae
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spelling	oai:doaj.org-article:dc6ca1232e844b7e87ff334666da85ae2021-12-02T15:08:19ZAssociation between dynamic resting-state functional connectivity and ketamine plasma levels in visual processing networks10.1038/s41598-019-46702-x2045-2322https://doaj.org/article/dc6ca1232e844b7e87ff334666da85ae2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-46702-xhttps://doaj.org/toc/2045-2322Abstract Numerous studies demonstrate ketamine’s influence on resting-state functional connectivity (rsFC). Seed-based and static rsFC estimation methods may oversimplify FC. These limitations can be addressed with whole-brain, dynamic rsFC estimation methods. We assessed data from 27 healthy subjects who underwent two 3 T resting-state fMRI scans, once under subanesthetic, intravenous esketamine and once under placebo, in a randomized, cross-over manner. We aimed to isolate only highly robust effects of esketamine on dynamic rsFC by using eight complementary methodologies derived from two dynamic rsFC estimation methods, two functionally defined atlases and two statistical measures. All combinations revealed a negative influence of esketamine on dynamic rsFC within the left visual network and inter-hemispherically between visual networks (p < 0.05, corrected), hereby suggesting that esketamine’s influence on dynamic rsFC is highly stable in visual processing networks. Our findings may be reflective of ketamine’s role as a model for psychosis, a disorder associated with alterations to visual processing and impaired inter-hemispheric connectivity. Ketamine is a highly effective antidepressant and studies have shown changes to sensory processing in depression. Dynamic rsFC in sensory processing networks might be a promising target for future investigations of ketamine’s antidepressant properties. Mechanistically, sensitivity of visual networks for esketamine’s effects may result from their high expression of NMDA-receptors.Marie SpiesManfred KlöblAnna HöflichAllan HummerThomas VanicekPaul MichenthalerGeorg S. KranzAndreas HahnDietmar WinklerChristian WindischbergerSiegfried KasperRupert LanzenbergerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marie Spies Manfred Klöbl Anna Höflich Allan Hummer Thomas Vanicek Paul Michenthaler Georg S. Kranz Andreas Hahn Dietmar Winkler Christian Windischberger Siegfried Kasper Rupert Lanzenberger Association between dynamic resting-state functional connectivity and ketamine plasma levels in visual processing networks
description	Abstract Numerous studies demonstrate ketamine’s influence on resting-state functional connectivity (rsFC). Seed-based and static rsFC estimation methods may oversimplify FC. These limitations can be addressed with whole-brain, dynamic rsFC estimation methods. We assessed data from 27 healthy subjects who underwent two 3 T resting-state fMRI scans, once under subanesthetic, intravenous esketamine and once under placebo, in a randomized, cross-over manner. We aimed to isolate only highly robust effects of esketamine on dynamic rsFC by using eight complementary methodologies derived from two dynamic rsFC estimation methods, two functionally defined atlases and two statistical measures. All combinations revealed a negative influence of esketamine on dynamic rsFC within the left visual network and inter-hemispherically between visual networks (p < 0.05, corrected), hereby suggesting that esketamine’s influence on dynamic rsFC is highly stable in visual processing networks. Our findings may be reflective of ketamine’s role as a model for psychosis, a disorder associated with alterations to visual processing and impaired inter-hemispheric connectivity. Ketamine is a highly effective antidepressant and studies have shown changes to sensory processing in depression. Dynamic rsFC in sensory processing networks might be a promising target for future investigations of ketamine’s antidepressant properties. Mechanistically, sensitivity of visual networks for esketamine’s effects may result from their high expression of NMDA-receptors.
format	article
author	Marie Spies Manfred Klöbl Anna Höflich Allan Hummer Thomas Vanicek Paul Michenthaler Georg S. Kranz Andreas Hahn Dietmar Winkler Christian Windischberger Siegfried Kasper Rupert Lanzenberger
author_facet	Marie Spies Manfred Klöbl Anna Höflich Allan Hummer Thomas Vanicek Paul Michenthaler Georg S. Kranz Andreas Hahn Dietmar Winkler Christian Windischberger Siegfried Kasper Rupert Lanzenberger
author_sort	Marie Spies
title	Association between dynamic resting-state functional connectivity and ketamine plasma levels in visual processing networks
title_short	Association between dynamic resting-state functional connectivity and ketamine plasma levels in visual processing networks
title_full	Association between dynamic resting-state functional connectivity and ketamine plasma levels in visual processing networks
title_fullStr	Association between dynamic resting-state functional connectivity and ketamine plasma levels in visual processing networks
title_full_unstemmed	Association between dynamic resting-state functional connectivity and ketamine plasma levels in visual processing networks
title_sort	association between dynamic resting-state functional connectivity and ketamine plasma levels in visual processing networks
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/dc6ca1232e844b7e87ff334666da85ae
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Association between dynamic resting-state functional connectivity and ketamine plasma levels in visual processing networks

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