Mitochondrial dynamics controls anti-tumour innate immunity by regulating CHIP-IRF1 axis stability

Mitochondrial dynamics controls anti-tumour innate immunity by regulating CHIP-IRF1 axis stability

Macrophage metabolism controls differentiation and subsequent adaptive immune responses. Here the authors show that mitochondrial membrane protein Fam73b regulates TLR-mediated mitochondrial switching of fusion to fission to induce IL-12 production via accumulation of Parkin and stabilization of IRF...

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Autores principales: Zhengjun Gao, Yiyuan Li, Fei Wang, Tao Huang, Keqi Fan, Yu Zhang, Jiangyan Zhong, Qian Cao, Tong Chao, Junling Jia, Shuo Yang, Long Zhang, Yichuan Xiao, Ji-Yong Zhou, Xin-Hua Feng, Jin Jin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/dc7193fdda694c78920d3ebbb5ca98eb
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spelling oai:doaj.org-article:dc7193fdda694c78920d3ebbb5ca98eb2021-12-02T14:40:46ZMitochondrial dynamics controls anti-tumour innate immunity by regulating CHIP-IRF1 axis stability10.1038/s41467-017-01919-02041-1723https://doaj.org/article/dc7193fdda694c78920d3ebbb5ca98eb2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01919-0https://doaj.org/toc/2041-1723Macrophage metabolism controls differentiation and subsequent adaptive immune responses. Here the authors show that mitochondrial membrane protein Fam73b regulates TLR-mediated mitochondrial switching of fusion to fission to induce IL-12 production via accumulation of Parkin and stabilization of IRF1 in macrophages, resulting in control of anti-tumor immunity in mice.Zhengjun GaoYiyuan LiFei WangTao HuangKeqi FanYu ZhangJiangyan ZhongQian CaoTong ChaoJunling JiaShuo YangLong ZhangYichuan XiaoJi-Yong ZhouXin-Hua FengJin JinNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Zhengjun Gao
Yiyuan Li
Fei Wang
Tao Huang
Keqi Fan
Yu Zhang
Jiangyan Zhong
Qian Cao
Tong Chao
Junling Jia
Shuo Yang
Long Zhang
Yichuan Xiao
Ji-Yong Zhou
Xin-Hua Feng
Jin Jin
Mitochondrial dynamics controls anti-tumour innate immunity by regulating CHIP-IRF1 axis stability
description Macrophage metabolism controls differentiation and subsequent adaptive immune responses. Here the authors show that mitochondrial membrane protein Fam73b regulates TLR-mediated mitochondrial switching of fusion to fission to induce IL-12 production via accumulation of Parkin and stabilization of IRF1 in macrophages, resulting in control of anti-tumor immunity in mice.
format article
author Zhengjun Gao
Yiyuan Li
Fei Wang
Tao Huang
Keqi Fan
Yu Zhang
Jiangyan Zhong
Qian Cao
Tong Chao
Junling Jia
Shuo Yang
Long Zhang
Yichuan Xiao
Ji-Yong Zhou
Xin-Hua Feng
Jin Jin
author_facet Zhengjun Gao
Yiyuan Li
Fei Wang
Tao Huang
Keqi Fan
Yu Zhang
Jiangyan Zhong
Qian Cao
Tong Chao
Junling Jia
Shuo Yang
Long Zhang
Yichuan Xiao
Ji-Yong Zhou
Xin-Hua Feng
Jin Jin
author_sort Zhengjun Gao
title Mitochondrial dynamics controls anti-tumour innate immunity by regulating CHIP-IRF1 axis stability
title_short Mitochondrial dynamics controls anti-tumour innate immunity by regulating CHIP-IRF1 axis stability
title_full Mitochondrial dynamics controls anti-tumour innate immunity by regulating CHIP-IRF1 axis stability
title_fullStr Mitochondrial dynamics controls anti-tumour innate immunity by regulating CHIP-IRF1 axis stability
title_full_unstemmed Mitochondrial dynamics controls anti-tumour innate immunity by regulating CHIP-IRF1 axis stability
title_sort mitochondrial dynamics controls anti-tumour innate immunity by regulating chip-irf1 axis stability
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/dc7193fdda694c78920d3ebbb5ca98eb
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