Proton-dynamic therapy following photosensitiser activation by accelerated protons demonstrated through fluorescence and singlet oxygen production

The authors use accelerated protons on photosensitizers (PS, conventionally excited by light), to generate fluorescence and singlet oxygen which can enhance the efficacy of proton therapy. A pilot study on glioblastoma cells confirms differential cell death upon irradiation in the presence of PS.

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Autores principales:	M. Grigalavicius, M. Mastrangelopoulou, K. Berg, D. Arous, M. Ménard, T. Raabe-Henriksen, E. Brondz, S. Siem, A. Görgen, N. F. J. Edin, E. Malinen, T. A. Theodossiou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dc72b20625074632a14bc5b01b33580c
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spelling	oai:doaj.org-article:dc72b20625074632a14bc5b01b33580c2021-12-02T15:35:47ZProton-dynamic therapy following photosensitiser activation by accelerated protons demonstrated through fluorescence and singlet oxygen production10.1038/s41467-019-12042-72041-1723https://doaj.org/article/dc72b20625074632a14bc5b01b33580c2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12042-7https://doaj.org/toc/2041-1723The authors use accelerated protons on photosensitizers (PS, conventionally excited by light), to generate fluorescence and singlet oxygen which can enhance the efficacy of proton therapy. A pilot study on glioblastoma cells confirms differential cell death upon irradiation in the presence of PS.M. GrigalaviciusM. MastrangelopoulouK. BergD. ArousM. MénardT. Raabe-HenriksenE. BrondzS. SiemA. GörgenN. F. J. EdinE. MalinenT. A. TheodossiouNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q M. Grigalavicius M. Mastrangelopoulou K. Berg D. Arous M. Ménard T. Raabe-Henriksen E. Brondz S. Siem A. Görgen N. F. J. Edin E. Malinen T. A. Theodossiou Proton-dynamic therapy following photosensitiser activation by accelerated protons demonstrated through fluorescence and singlet oxygen production
description	The authors use accelerated protons on photosensitizers (PS, conventionally excited by light), to generate fluorescence and singlet oxygen which can enhance the efficacy of proton therapy. A pilot study on glioblastoma cells confirms differential cell death upon irradiation in the presence of PS.
format	article
author	M. Grigalavicius M. Mastrangelopoulou K. Berg D. Arous M. Ménard T. Raabe-Henriksen E. Brondz S. Siem A. Görgen N. F. J. Edin E. Malinen T. A. Theodossiou
author_facet	M. Grigalavicius M. Mastrangelopoulou K. Berg D. Arous M. Ménard T. Raabe-Henriksen E. Brondz S. Siem A. Görgen N. F. J. Edin E. Malinen T. A. Theodossiou
author_sort	M. Grigalavicius
title	Proton-dynamic therapy following photosensitiser activation by accelerated protons demonstrated through fluorescence and singlet oxygen production
title_short	Proton-dynamic therapy following photosensitiser activation by accelerated protons demonstrated through fluorescence and singlet oxygen production
title_full	Proton-dynamic therapy following photosensitiser activation by accelerated protons demonstrated through fluorescence and singlet oxygen production
title_fullStr	Proton-dynamic therapy following photosensitiser activation by accelerated protons demonstrated through fluorescence and singlet oxygen production
title_full_unstemmed	Proton-dynamic therapy following photosensitiser activation by accelerated protons demonstrated through fluorescence and singlet oxygen production
title_sort	proton-dynamic therapy following photosensitiser activation by accelerated protons demonstrated through fluorescence and singlet oxygen production
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/dc72b20625074632a14bc5b01b33580c
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Proton-dynamic therapy following photosensitiser activation by accelerated protons demonstrated through fluorescence and singlet oxygen production

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