Association of Postoperative Radiotherapy Delay with Relapse and Metastasis in Women with Breast Cancer Using Penalized Cox Regression

Background: The impact of initiation time of radiotherapy after breast surgery on disease-free status of patient is a controversial issue. We assessed the relationship between the delay in adjuvant radiotherapy and surgery and relapse or metastasisfree survival in women with breast cancer taking hea...

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Autores principales:	Fatemeh Homaei Shandiz, Vahid Ghavami, Nooshin Akbari Sharak, Mohammad Reza Saghafi, Saeedeh Hajebi Khaniki
Formato:	article
Lenguaje:	EN
Publicado:	Shiraz University of Medical Sciences 2021
Materias:	penalized cox regression breast neoplasm radiotherapy delay local relapse metastasis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/dc732db885ac4558b5279c506dba12d5
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spelling	oai:doaj.org-article:dc732db885ac4558b5279c506dba12d52021-11-29T10:40:47ZAssociation of Postoperative Radiotherapy Delay with Relapse and Metastasis in Women with Breast Cancer Using Penalized Cox Regression2008-67092008-668710.30476/mejc.2021.86391.1340https://doaj.org/article/dc732db885ac4558b5279c506dba12d52021-10-01T00:00:00Zhttps://mejc.sums.ac.ir/article_47541_d77336a8e01612f055c0f6ce5f630f64.pdfhttps://doaj.org/toc/2008-6709https://doaj.org/toc/2008-6687Background: The impact of initiation time of radiotherapy after breast surgery on disease-free status of patient is a controversial issue. We assessed the relationship between the delay in adjuvant radiotherapy and surgery and relapse or metastasisfree survival in women with breast cancer taking heavy censoring into account. Method: This was a historical cohort study on 284 patients with breast cancer, who underwent surgery between 2001 and 2007 and followed up until March 2017. The association of the duration between radiotherapy and surgery, as well as other demographic and clinical factors with occurrence of local relapse or metastasis of breast cancer was examined through penalized Cox regression modeling. The obtained data were analyzed using R 3.6.3. Results: A total of 284 women with the mean age of 47.2 ± 11.3 years met the inclusion criteria. The maximum follow-up time was 11.1 years and the time between surgery and radiotherapy was 168 ± 84.3 days. About 10% of the patients experienced local relapse and 19% had metastasis. In multiple analysis of factors related to diseasefree survival, the stage of disease was significant, while surgery to radiotherapy interval (≤180 days vs >180 days) did not have any significant impact on hazard of failure. Analysis of 3, 4, or 5 months of delay in radiation therapy did not imply any significant affects. Conclusion: In the studied patients, the delay in radiotherapy initiation after surgery did not lead into outcomes of local relapse or metastasis.Fatemeh Homaei ShandizVahid GhavamiNooshin Akbari SharakMohammad Reza SaghafiSaeedeh Hajebi KhanikiShiraz University of Medical Sciencesarticlepenalized cox regressionbreast neoplasmradiotherapy delaylocal relapsemetastasisNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENMiddle East Journal of Cancer , Vol 12, Iss 4, Pp 543-551 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	penalized cox regression breast neoplasm radiotherapy delay local relapse metastasis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	penalized cox regression breast neoplasm radiotherapy delay local relapse metastasis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Fatemeh Homaei Shandiz Vahid Ghavami Nooshin Akbari Sharak Mohammad Reza Saghafi Saeedeh Hajebi Khaniki Association of Postoperative Radiotherapy Delay with Relapse and Metastasis in Women with Breast Cancer Using Penalized Cox Regression
description	Background: The impact of initiation time of radiotherapy after breast surgery on disease-free status of patient is a controversial issue. We assessed the relationship between the delay in adjuvant radiotherapy and surgery and relapse or metastasisfree survival in women with breast cancer taking heavy censoring into account. Method: This was a historical cohort study on 284 patients with breast cancer, who underwent surgery between 2001 and 2007 and followed up until March 2017. The association of the duration between radiotherapy and surgery, as well as other demographic and clinical factors with occurrence of local relapse or metastasis of breast cancer was examined through penalized Cox regression modeling. The obtained data were analyzed using R 3.6.3. Results: A total of 284 women with the mean age of 47.2 ± 11.3 years met the inclusion criteria. The maximum follow-up time was 11.1 years and the time between surgery and radiotherapy was 168 ± 84.3 days. About 10% of the patients experienced local relapse and 19% had metastasis. In multiple analysis of factors related to diseasefree survival, the stage of disease was significant, while surgery to radiotherapy interval (≤180 days vs >180 days) did not have any significant impact on hazard of failure. Analysis of 3, 4, or 5 months of delay in radiation therapy did not imply any significant affects. Conclusion: In the studied patients, the delay in radiotherapy initiation after surgery did not lead into outcomes of local relapse or metastasis.
format	article
author	Fatemeh Homaei Shandiz Vahid Ghavami Nooshin Akbari Sharak Mohammad Reza Saghafi Saeedeh Hajebi Khaniki
author_facet	Fatemeh Homaei Shandiz Vahid Ghavami Nooshin Akbari Sharak Mohammad Reza Saghafi Saeedeh Hajebi Khaniki
author_sort	Fatemeh Homaei Shandiz
title	Association of Postoperative Radiotherapy Delay with Relapse and Metastasis in Women with Breast Cancer Using Penalized Cox Regression
title_short	Association of Postoperative Radiotherapy Delay with Relapse and Metastasis in Women with Breast Cancer Using Penalized Cox Regression
title_full	Association of Postoperative Radiotherapy Delay with Relapse and Metastasis in Women with Breast Cancer Using Penalized Cox Regression
title_fullStr	Association of Postoperative Radiotherapy Delay with Relapse and Metastasis in Women with Breast Cancer Using Penalized Cox Regression
title_full_unstemmed	Association of Postoperative Radiotherapy Delay with Relapse and Metastasis in Women with Breast Cancer Using Penalized Cox Regression
title_sort	association of postoperative radiotherapy delay with relapse and metastasis in women with breast cancer using penalized cox regression
publisher	Shiraz University of Medical Sciences
publishDate	2021
url	https://doaj.org/article/dc732db885ac4558b5279c506dba12d5
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Association of Postoperative Radiotherapy Delay with Relapse and Metastasis in Women with Breast Cancer Using Penalized Cox Regression

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