MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance

Neuroendocrine differentiation of epithelial tumor cells can contribute to cancer cell resistance and survival. Here, the authors show that dysregulated c-Myc promotes neuroendocrine differentiation in pancreatic ductal adenocarcinoma, leading to poor survival and chemoresistance.

Guardado en:

Detalles Bibliográficos
Autores principales:	Amy S. Farrell, Meghan Morrison Joly, Brittany L. Allen-Petersen, Patrick J. Worth, Christian Lanciault, David Sauer, Jason Link, Carl Pelz, Laura M. Heiser, Jennifer P. Morton, Nathiya Muthalagu, Megan T. Hoffman, Sara L. Manning, Erica D. Pratt, Nicholas D. Kendsersky, Nkolika Egbukichi, Taylor S. Amery, Mary C. Thoma, Zina P. Jenny, Andrew D. Rhim, Daniel J. Murphy, Owen J. Sansom, Howard C. Crawford, Brett C. Sheppard, Rosalie C. Sears
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dc766b609bac46f8805ef957d3259818
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:dc766b609bac46f8805ef957d3259818
record_format	dspace
spelling	oai:doaj.org-article:dc766b609bac46f8805ef957d32598182021-12-02T17:06:26ZMYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance10.1038/s41467-017-01967-62041-1723https://doaj.org/article/dc766b609bac46f8805ef957d32598182017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01967-6https://doaj.org/toc/2041-1723Neuroendocrine differentiation of epithelial tumor cells can contribute to cancer cell resistance and survival. Here, the authors show that dysregulated c-Myc promotes neuroendocrine differentiation in pancreatic ductal adenocarcinoma, leading to poor survival and chemoresistance.Amy S. FarrellMeghan Morrison JolyBrittany L. Allen-PetersenPatrick J. WorthChristian LanciaultDavid SauerJason LinkCarl PelzLaura M. HeiserJennifer P. MortonNathiya MuthalaguMegan T. HoffmanSara L. ManningErica D. PrattNicholas D. KendserskyNkolika EgbukichiTaylor S. AmeryMary C. ThomaZina P. JennyAndrew D. RhimDaniel J. MurphyOwen J. SansomHoward C. CrawfordBrett C. SheppardRosalie C. SearsNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Amy S. Farrell Meghan Morrison Joly Brittany L. Allen-Petersen Patrick J. Worth Christian Lanciault David Sauer Jason Link Carl Pelz Laura M. Heiser Jennifer P. Morton Nathiya Muthalagu Megan T. Hoffman Sara L. Manning Erica D. Pratt Nicholas D. Kendsersky Nkolika Egbukichi Taylor S. Amery Mary C. Thoma Zina P. Jenny Andrew D. Rhim Daniel J. Murphy Owen J. Sansom Howard C. Crawford Brett C. Sheppard Rosalie C. Sears MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance
description	Neuroendocrine differentiation of epithelial tumor cells can contribute to cancer cell resistance and survival. Here, the authors show that dysregulated c-Myc promotes neuroendocrine differentiation in pancreatic ductal adenocarcinoma, leading to poor survival and chemoresistance.
format	article
author	Amy S. Farrell Meghan Morrison Joly Brittany L. Allen-Petersen Patrick J. Worth Christian Lanciault David Sauer Jason Link Carl Pelz Laura M. Heiser Jennifer P. Morton Nathiya Muthalagu Megan T. Hoffman Sara L. Manning Erica D. Pratt Nicholas D. Kendsersky Nkolika Egbukichi Taylor S. Amery Mary C. Thoma Zina P. Jenny Andrew D. Rhim Daniel J. Murphy Owen J. Sansom Howard C. Crawford Brett C. Sheppard Rosalie C. Sears
author_facet	Amy S. Farrell Meghan Morrison Joly Brittany L. Allen-Petersen Patrick J. Worth Christian Lanciault David Sauer Jason Link Carl Pelz Laura M. Heiser Jennifer P. Morton Nathiya Muthalagu Megan T. Hoffman Sara L. Manning Erica D. Pratt Nicholas D. Kendsersky Nkolika Egbukichi Taylor S. Amery Mary C. Thoma Zina P. Jenny Andrew D. Rhim Daniel J. Murphy Owen J. Sansom Howard C. Crawford Brett C. Sheppard Rosalie C. Sears
author_sort	Amy S. Farrell
title	MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance
title_short	MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance
title_full	MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance
title_fullStr	MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance
title_full_unstemmed	MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance
title_sort	myc regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/dc766b609bac46f8805ef957d3259818
work_keys_str_mv	AT amysfarrell mycregulatesductalneuroendocrinelineageplasticityinpancreaticductaladenocarcinomaassociatedwithpooroutcomeandchemoresistance AT meghanmorrisonjoly mycregulatesductalneuroendocrinelineageplasticityinpancreaticductaladenocarcinomaassociatedwithpooroutcomeandchemoresistance AT brittanylallenpetersen mycregulatesductalneuroendocrinelineageplasticityinpancreaticductaladenocarcinomaassociatedwithpooroutcomeandchemoresistance AT patrickjworth mycregulatesductalneuroendocrinelineageplasticityinpancreaticductaladenocarcinomaassociatedwithpooroutcomeandchemoresistance AT christianlanciault mycregulatesductalneuroendocrinelineageplasticityinpancreaticductaladenocarcinomaassociatedwithpooroutcomeandchemoresistance AT davidsauer mycregulatesductalneuroendocrinelineageplasticityinpancreaticductaladenocarcinomaassociatedwithpooroutcomeandchemoresistance AT jasonlink mycregulatesductalneuroendocrinelineageplasticityinpancreaticductaladenocarcinomaassociatedwithpooroutcomeandchemoresistance AT carlpelz mycregulatesductalneuroendocrinelineageplasticityinpancreaticductaladenocarcinomaassociatedwithpooroutcomeandchemoresistance AT lauramheiser mycregulatesductalneuroendocrinelineageplasticityinpancreaticductaladenocarcinomaassociatedwithpooroutcomeandchemoresistance AT jenniferpmorton mycregulatesductalneuroendocrinelineageplasticityinpancreaticductaladenocarcinomaassociatedwithpooroutcomeandchemoresistance AT nathiyamuthalagu mycregulatesductalneuroendocrinelineageplasticityinpancreaticductaladenocarcinomaassociatedwithpooroutcomeandchemoresistance AT meganthoffman mycregulatesductalneuroendocrinelineageplasticityinpancreaticductaladenocarcinomaassociatedwithpooroutcomeandchemoresistance AT saralmanning mycregulatesductalneuroendocrinelineageplasticityinpancreaticductaladenocarcinomaassociatedwithpooroutcomeandchemoresistance AT ericadpratt mycregulatesductalneuroendocrinelineageplasticityinpancreaticductaladenocarcinomaassociatedwithpooroutcomeandchemoresistance AT nicholasdkendsersky mycregulatesductalneuroendocrinelineageplasticityinpancreaticductaladenocarcinomaassociatedwithpooroutcomeandchemoresistance AT nkolikaegbukichi mycregulatesductalneuroendocrinelineageplasticityinpancreaticductaladenocarcinomaassociatedwithpooroutcomeandchemoresistance AT taylorsamery mycregulatesductalneuroendocrinelineageplasticityinpancreaticductaladenocarcinomaassociatedwithpooroutcomeandchemoresistance AT marycthoma mycregulatesductalneuroendocrinelineageplasticityinpancreaticductaladenocarcinomaassociatedwithpooroutcomeandchemoresistance AT zinapjenny mycregulatesductalneuroendocrinelineageplasticityinpancreaticductaladenocarcinomaassociatedwithpooroutcomeandchemoresistance AT andrewdrhim mycregulatesductalneuroendocrinelineageplasticityinpancreaticductaladenocarcinomaassociatedwithpooroutcomeandchemoresistance AT danieljmurphy mycregulatesductalneuroendocrinelineageplasticityinpancreaticductaladenocarcinomaassociatedwithpooroutcomeandchemoresistance AT owenjsansom mycregulatesductalneuroendocrinelineageplasticityinpancreaticductaladenocarcinomaassociatedwithpooroutcomeandchemoresistance AT howardccrawford mycregulatesductalneuroendocrinelineageplasticityinpancreaticductaladenocarcinomaassociatedwithpooroutcomeandchemoresistance AT brettcsheppard mycregulatesductalneuroendocrinelineageplasticityinpancreaticductaladenocarcinomaassociatedwithpooroutcomeandchemoresistance AT rosaliecsears mycregulatesductalneuroendocrinelineageplasticityinpancreaticductaladenocarcinomaassociatedwithpooroutcomeandchemoresistance
_version_	1718381643684642816

MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance

Ejemplares similares