Ancient role of sulfakinin/cholecystokinin-type signalling in inhibitory regulation of feeding processes revealed in an echinoderm

Sulfakinin (SK)/cholecystokinin (CCK)-type neuropeptides regulate feeding and digestion in protostomes (e.g. insects) and chordates. Here, we characterised SK/CCK-type signalling for the first time in a non-chordate deuterostome – the starfish Asterias rubens (phylum Echinodermata). In this species,...

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Autores principales:	Ana B Tinoco, Antón Barreiro-Iglesias, Luis Alfonso Yañez Guerra, Jérôme Delroisse, Ya Zhang, Elizabeth F Gunner, Cleidiane G Zampronio, Alexandra M Jones, Michaela Egertová, Maurice R Elphick
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	Asterias rubens starfish sulfakinin/cholecystokinin neuropeptides feeding receptors Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/dc7723c7cb414f809705a7edef0e5a3b
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spelling	oai:doaj.org-article:dc7723c7cb414f809705a7edef0e5a3b2021-11-14T15:21:19ZAncient role of sulfakinin/cholecystokinin-type signalling in inhibitory regulation of feeding processes revealed in an echinoderm10.7554/eLife.656672050-084Xe65667https://doaj.org/article/dc7723c7cb414f809705a7edef0e5a3b2021-09-01T00:00:00Zhttps://elifesciences.org/articles/65667https://doaj.org/toc/2050-084XSulfakinin (SK)/cholecystokinin (CCK)-type neuropeptides regulate feeding and digestion in protostomes (e.g. insects) and chordates. Here, we characterised SK/CCK-type signalling for the first time in a non-chordate deuterostome – the starfish Asterias rubens (phylum Echinodermata). In this species, two neuropeptides (ArSK/CCK1, ArSK/CCK2) derived from the precursor protein ArSK/CCKP act as ligands for an SK/CCK-type receptor (ArSK/CCKR) and these peptides/proteins are expressed in the nervous system, digestive system, tube feet, and body wall. Furthermore, ArSK/CCK1 and ArSK/CCK2 cause dose-dependent contraction of cardiac stomach, tube foot, and apical muscle preparations in vitro, and injection of these neuropeptides in vivo triggers cardiac stomach retraction and inhibition of the onset of feeding in A. rubens. Thus, an evolutionarily ancient role of SK/CCK-type neuropeptides as inhibitory regulators of feeding-related processes in the Bilateria has been conserved in the unusual and unique context of the extra-oral feeding behaviour and pentaradial body plan of an echinoderm.Ana B TinocoAntón Barreiro-IglesiasLuis Alfonso Yañez GuerraJérôme DelroisseYa ZhangElizabeth F GunnerCleidiane G ZampronioAlexandra M JonesMichaela EgertováMaurice R ElphickeLife Sciences Publications LtdarticleAsterias rubensstarfishsulfakinin/cholecystokininneuropeptidesfeedingreceptorsMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Asterias rubens starfish sulfakinin/cholecystokinin neuropeptides feeding receptors Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	Asterias rubens starfish sulfakinin/cholecystokinin neuropeptides feeding receptors Medicine R Science Q Biology (General) QH301-705.5 Ana B Tinoco Antón Barreiro-Iglesias Luis Alfonso Yañez Guerra Jérôme Delroisse Ya Zhang Elizabeth F Gunner Cleidiane G Zampronio Alexandra M Jones Michaela Egertová Maurice R Elphick Ancient role of sulfakinin/cholecystokinin-type signalling in inhibitory regulation of feeding processes revealed in an echinoderm
description	Sulfakinin (SK)/cholecystokinin (CCK)-type neuropeptides regulate feeding and digestion in protostomes (e.g. insects) and chordates. Here, we characterised SK/CCK-type signalling for the first time in a non-chordate deuterostome – the starfish Asterias rubens (phylum Echinodermata). In this species, two neuropeptides (ArSK/CCK1, ArSK/CCK2) derived from the precursor protein ArSK/CCKP act as ligands for an SK/CCK-type receptor (ArSK/CCKR) and these peptides/proteins are expressed in the nervous system, digestive system, tube feet, and body wall. Furthermore, ArSK/CCK1 and ArSK/CCK2 cause dose-dependent contraction of cardiac stomach, tube foot, and apical muscle preparations in vitro, and injection of these neuropeptides in vivo triggers cardiac stomach retraction and inhibition of the onset of feeding in A. rubens. Thus, an evolutionarily ancient role of SK/CCK-type neuropeptides as inhibitory regulators of feeding-related processes in the Bilateria has been conserved in the unusual and unique context of the extra-oral feeding behaviour and pentaradial body plan of an echinoderm.
format	article
author	Ana B Tinoco Antón Barreiro-Iglesias Luis Alfonso Yañez Guerra Jérôme Delroisse Ya Zhang Elizabeth F Gunner Cleidiane G Zampronio Alexandra M Jones Michaela Egertová Maurice R Elphick
author_facet	Ana B Tinoco Antón Barreiro-Iglesias Luis Alfonso Yañez Guerra Jérôme Delroisse Ya Zhang Elizabeth F Gunner Cleidiane G Zampronio Alexandra M Jones Michaela Egertová Maurice R Elphick
author_sort	Ana B Tinoco
title	Ancient role of sulfakinin/cholecystokinin-type signalling in inhibitory regulation of feeding processes revealed in an echinoderm
title_short	Ancient role of sulfakinin/cholecystokinin-type signalling in inhibitory regulation of feeding processes revealed in an echinoderm
title_full	Ancient role of sulfakinin/cholecystokinin-type signalling in inhibitory regulation of feeding processes revealed in an echinoderm
title_fullStr	Ancient role of sulfakinin/cholecystokinin-type signalling in inhibitory regulation of feeding processes revealed in an echinoderm
title_full_unstemmed	Ancient role of sulfakinin/cholecystokinin-type signalling in inhibitory regulation of feeding processes revealed in an echinoderm
title_sort	ancient role of sulfakinin/cholecystokinin-type signalling in inhibitory regulation of feeding processes revealed in an echinoderm
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/dc7723c7cb414f809705a7edef0e5a3b
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Ancient role of sulfakinin/cholecystokinin-type signalling in inhibitory regulation of feeding processes revealed in an echinoderm

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