Nipah virus W protein harnesses nuclear 14-3-3 to inhibit NF-κB-induced proinflammatory response

In a study using both human cells and the African green monkeys, Enchery et al report that the highly pathogenic bat-borne Nipah virus (NiV), inhibits the NF-κB pathway via its nonstructural W protein. They demonstrate that it exerts this effect by causing nuclear accumulation of the cellular scaffo...

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Autores principales:	François Enchéry, Claire Dumont, Mathieu Iampietro, Rodolphe Pelissier, Noémie Aurine, Louis-Marie Bloyet, Caroline Carbonnelle, Cyrille Mathieu, Chloé Journo, Denis Gerlier, Branka Horvat
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/dc79959663c145a4baf6f7ace28e5108
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spelling	oai:doaj.org-article:dc79959663c145a4baf6f7ace28e51082021-11-21T12:08:15ZNipah virus W protein harnesses nuclear 14-3-3 to inhibit NF-κB-induced proinflammatory response10.1038/s42003-021-02797-52399-3642https://doaj.org/article/dc79959663c145a4baf6f7ace28e51082021-11-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02797-5https://doaj.org/toc/2399-3642In a study using both human cells and the African green monkeys, Enchery et al report that the highly pathogenic bat-borne Nipah virus (NiV), inhibits the NF-κB pathway via its nonstructural W protein. They demonstrate that it exerts this effect by causing nuclear accumulation of the cellular scaffold protein 14-3-3, which sheds light on pathomechanism of NiV infection.François EnchéryClaire DumontMathieu IampietroRodolphe PelissierNoémie AurineLouis-Marie BloyetCaroline CarbonnelleCyrille MathieuChloé JournoDenis GerlierBranka HorvatNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 François Enchéry Claire Dumont Mathieu Iampietro Rodolphe Pelissier Noémie Aurine Louis-Marie Bloyet Caroline Carbonnelle Cyrille Mathieu Chloé Journo Denis Gerlier Branka Horvat Nipah virus W protein harnesses nuclear 14-3-3 to inhibit NF-κB-induced proinflammatory response
description	In a study using both human cells and the African green monkeys, Enchery et al report that the highly pathogenic bat-borne Nipah virus (NiV), inhibits the NF-κB pathway via its nonstructural W protein. They demonstrate that it exerts this effect by causing nuclear accumulation of the cellular scaffold protein 14-3-3, which sheds light on pathomechanism of NiV infection.
format	article
author	François Enchéry Claire Dumont Mathieu Iampietro Rodolphe Pelissier Noémie Aurine Louis-Marie Bloyet Caroline Carbonnelle Cyrille Mathieu Chloé Journo Denis Gerlier Branka Horvat
author_facet	François Enchéry Claire Dumont Mathieu Iampietro Rodolphe Pelissier Noémie Aurine Louis-Marie Bloyet Caroline Carbonnelle Cyrille Mathieu Chloé Journo Denis Gerlier Branka Horvat
author_sort	François Enchéry
title	Nipah virus W protein harnesses nuclear 14-3-3 to inhibit NF-κB-induced proinflammatory response
title_short	Nipah virus W protein harnesses nuclear 14-3-3 to inhibit NF-κB-induced proinflammatory response
title_full	Nipah virus W protein harnesses nuclear 14-3-3 to inhibit NF-κB-induced proinflammatory response
title_fullStr	Nipah virus W protein harnesses nuclear 14-3-3 to inhibit NF-κB-induced proinflammatory response
title_full_unstemmed	Nipah virus W protein harnesses nuclear 14-3-3 to inhibit NF-κB-induced proinflammatory response
title_sort	nipah virus w protein harnesses nuclear 14-3-3 to inhibit nf-κb-induced proinflammatory response
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dc79959663c145a4baf6f7ace28e5108
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Nipah virus W protein harnesses nuclear 14-3-3 to inhibit NF-κB-induced proinflammatory response

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