Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning

Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning

Oligodendrocyte differentiation is known to depend on transcription factors Sox10, Nkx2.2, and Olig2. Here, the authors show that Nfat/calcineurin signaling contributes to oligodendrocyte differentiation by relieving mutual repression of Nkx2.2 and Olig2.

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Detalles Bibliográficos
Autores principales: Matthias Weider, Laura Julia Starost, Katharina Groll, Melanie Küspert, Elisabeth Sock, Miriam Wedel, Franziska Fröb, Christian Schmitt, Tina Baroti, Anna C. Hartwig, Simone Hillgärtner, Sandra Piefke, Tanja Fadler, Marc Ehrlich, Corinna Ehlert, Martin Stehling, Stefanie Albrecht, Ammar Jabali, Hans R. Schöler, Jürgen Winkler, Tanja Kuhlmann, Michael Wegner
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/dc813a76f1a44fa790c36e641522a47c
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Sumario:Oligodendrocyte differentiation is known to depend on transcription factors Sox10, Nkx2.2, and Olig2. Here, the authors show that Nfat/calcineurin signaling contributes to oligodendrocyte differentiation by relieving mutual repression of Nkx2.2 and Olig2.

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