Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning

Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning

Oligodendrocyte differentiation is known to depend on transcription factors Sox10, Nkx2.2, and Olig2. Here, the authors show that Nfat/calcineurin signaling contributes to oligodendrocyte differentiation by relieving mutual repression of Nkx2.2 and Olig2.

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Autores principales: Matthias Weider, Laura Julia Starost, Katharina Groll, Melanie Küspert, Elisabeth Sock, Miriam Wedel, Franziska Fröb, Christian Schmitt, Tina Baroti, Anna C. Hartwig, Simone Hillgärtner, Sandra Piefke, Tanja Fadler, Marc Ehrlich, Corinna Ehlert, Martin Stehling, Stefanie Albrecht, Ammar Jabali, Hans R. Schöler, Jürgen Winkler, Tanja Kuhlmann, Michael Wegner
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/dc813a76f1a44fa790c36e641522a47c
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spelling oai:doaj.org-article:dc813a76f1a44fa790c36e641522a47c2021-12-02T17:31:44ZNfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning10.1038/s41467-018-03336-32041-1723https://doaj.org/article/dc813a76f1a44fa790c36e641522a47c2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03336-3https://doaj.org/toc/2041-1723Oligodendrocyte differentiation is known to depend on transcription factors Sox10, Nkx2.2, and Olig2. Here, the authors show that Nfat/calcineurin signaling contributes to oligodendrocyte differentiation by relieving mutual repression of Nkx2.2 and Olig2.Matthias WeiderLaura Julia StarostKatharina GrollMelanie KüspertElisabeth SockMiriam WedelFranziska FröbChristian SchmittTina BarotiAnna C. HartwigSimone HillgärtnerSandra PiefkeTanja FadlerMarc EhrlichCorinna EhlertMartin StehlingStefanie AlbrechtAmmar JabaliHans R. SchölerJürgen WinklerTanja KuhlmannMichael WegnerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Matthias Weider
Laura Julia Starost
Katharina Groll
Melanie Küspert
Elisabeth Sock
Miriam Wedel
Franziska Fröb
Christian Schmitt
Tina Baroti
Anna C. Hartwig
Simone Hillgärtner
Sandra Piefke
Tanja Fadler
Marc Ehrlich
Corinna Ehlert
Martin Stehling
Stefanie Albrecht
Ammar Jabali
Hans R. Schöler
Jürgen Winkler
Tanja Kuhlmann
Michael Wegner
Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning
description Oligodendrocyte differentiation is known to depend on transcription factors Sox10, Nkx2.2, and Olig2. Here, the authors show that Nfat/calcineurin signaling contributes to oligodendrocyte differentiation by relieving mutual repression of Nkx2.2 and Olig2.
format article
author Matthias Weider
Laura Julia Starost
Katharina Groll
Melanie Küspert
Elisabeth Sock
Miriam Wedel
Franziska Fröb
Christian Schmitt
Tina Baroti
Anna C. Hartwig
Simone Hillgärtner
Sandra Piefke
Tanja Fadler
Marc Ehrlich
Corinna Ehlert
Martin Stehling
Stefanie Albrecht
Ammar Jabali
Hans R. Schöler
Jürgen Winkler
Tanja Kuhlmann
Michael Wegner
author_facet Matthias Weider
Laura Julia Starost
Katharina Groll
Melanie Küspert
Elisabeth Sock
Miriam Wedel
Franziska Fröb
Christian Schmitt
Tina Baroti
Anna C. Hartwig
Simone Hillgärtner
Sandra Piefke
Tanja Fadler
Marc Ehrlich
Corinna Ehlert
Martin Stehling
Stefanie Albrecht
Ammar Jabali
Hans R. Schöler
Jürgen Winkler
Tanja Kuhlmann
Michael Wegner
author_sort Matthias Weider
title Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning
title_short Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning
title_full Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning
title_fullStr Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning
title_full_unstemmed Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning
title_sort nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/dc813a76f1a44fa790c36e641522a47c
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