A Retrospective Study of the Effects of Psychotropic Drugs on Neuroendocrine Hormones in Patients with Bipolar Disorder

Shengnan Zhao, Bo Zhang, Xueli Sun Mental Health Center, West China Hospital of Sichuan University, Chengdu, Sichuan, People’s Republic of ChinaCorrespondence: Xueli SunMental Health Center, West China Hospital of Sichuan University, Chengdu, Sichuan, People’s Republic of ChinaTe...

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Autores principales:	Zhao S, Zhang B, Sun X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	bipolar disorder psychotropic drugs neuroendocrine hormones Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/dc842d5c380841c28c09587a11d7093d
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spelling	oai:doaj.org-article:dc842d5c380841c28c09587a11d7093d2021-12-02T15:53:36ZA Retrospective Study of the Effects of Psychotropic Drugs on Neuroendocrine Hormones in Patients with Bipolar Disorder1178-2021https://doaj.org/article/dc842d5c380841c28c09587a11d7093d2021-05-01T00:00:00Zhttps://www.dovepress.com/a-retrospective-study-of-the-effects-of-psychotropic-drugs-on-neuroend-peer-reviewed-fulltext-article-NDThttps://doaj.org/toc/1178-2021Shengnan Zhao, Bo Zhang, Xueli Sun Mental Health Center, West China Hospital of Sichuan University, Chengdu, Sichuan, People’s Republic of ChinaCorrespondence: Xueli SunMental Health Center, West China Hospital of Sichuan University, Chengdu, Sichuan, People’s Republic of ChinaTel +86-17323085880Email sunxuelihx@163.comBackground: Bipolar disorder (BD) is predominantly treated with medication, and previous studies have shown that psychotropic drugs have an effect on the neuroendocrine system. And the objectives of this study were: 1) to assess changes in neuroendocrine hormones of HPA axis and HPT axis in patients with BD after psychotropic drug treatment; 2) to determine differences in the above neuroendocrine hormones between psychotropic drug monotherapy and polytherapy treated patients.Methods: This study was a retrospective study that included 188 subjects.Results: After psychotropic drugs treatment, TSH levels increased significantly from baseline (p< 0.001) and FT3, TT3, FT4, TT4, ACTH and CORT levels decreased significantly from baseline (p< 0.001, p< 0.001, p< 0.001, p=0.007, p=0.039, p=0.031). There was no significant difference in hormonal changes between the monotherapy group and the polytherapy group, even though the polytherapy group was further divided into 4 subgroups. And there was no correlation between changes in hormones and treatment duration.Conclusion: Although the incidence of significant HPT axis and HPA axis dysfunction after psychotropic drug treatment is low in patients with BD who have normal baseline neuroendocrine hormone levels, psychotropic drug treatment does suppress HPT axis and HPA axis function irrespective of the use of psychotropic drugs alone or in combination, and duration of psychotropic drug treatment. Therefore, even patients with BD who have normal baseline levels of neuroendocrine hormones should have their neuroendocrine hormone levels regularly monitored after psychotropic drug medication. But, the interval of monitoring can be slightly longer, which can be once every six months after taking psychotropic drugs.Keywords: bipolar disorder, psychotropic drugs, neuroendocrine hormonesZhao SZhang BSun XDove Medical Pressarticlebipolar disorderpsychotropic drugsneuroendocrine hormonesNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 1543-1550 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bipolar disorder psychotropic drugs neuroendocrine hormones Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	bipolar disorder psychotropic drugs neuroendocrine hormones Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Zhao S Zhang B Sun X A Retrospective Study of the Effects of Psychotropic Drugs on Neuroendocrine Hormones in Patients with Bipolar Disorder
description	Shengnan Zhao, Bo Zhang, Xueli Sun Mental Health Center, West China Hospital of Sichuan University, Chengdu, Sichuan, People’s Republic of ChinaCorrespondence: Xueli SunMental Health Center, West China Hospital of Sichuan University, Chengdu, Sichuan, People’s Republic of ChinaTel +86-17323085880Email sunxuelihx@163.comBackground: Bipolar disorder (BD) is predominantly treated with medication, and previous studies have shown that psychotropic drugs have an effect on the neuroendocrine system. And the objectives of this study were: 1) to assess changes in neuroendocrine hormones of HPA axis and HPT axis in patients with BD after psychotropic drug treatment; 2) to determine differences in the above neuroendocrine hormones between psychotropic drug monotherapy and polytherapy treated patients.Methods: This study was a retrospective study that included 188 subjects.Results: After psychotropic drugs treatment, TSH levels increased significantly from baseline (p< 0.001) and FT3, TT3, FT4, TT4, ACTH and CORT levels decreased significantly from baseline (p< 0.001, p< 0.001, p< 0.001, p=0.007, p=0.039, p=0.031). There was no significant difference in hormonal changes between the monotherapy group and the polytherapy group, even though the polytherapy group was further divided into 4 subgroups. And there was no correlation between changes in hormones and treatment duration.Conclusion: Although the incidence of significant HPT axis and HPA axis dysfunction after psychotropic drug treatment is low in patients with BD who have normal baseline neuroendocrine hormone levels, psychotropic drug treatment does suppress HPT axis and HPA axis function irrespective of the use of psychotropic drugs alone or in combination, and duration of psychotropic drug treatment. Therefore, even patients with BD who have normal baseline levels of neuroendocrine hormones should have their neuroendocrine hormone levels regularly monitored after psychotropic drug medication. But, the interval of monitoring can be slightly longer, which can be once every six months after taking psychotropic drugs.Keywords: bipolar disorder, psychotropic drugs, neuroendocrine hormones
format	article
author	Zhao S Zhang B Sun X
author_facet	Zhao S Zhang B Sun X
author_sort	Zhao S
title	A Retrospective Study of the Effects of Psychotropic Drugs on Neuroendocrine Hormones in Patients with Bipolar Disorder
title_short	A Retrospective Study of the Effects of Psychotropic Drugs on Neuroendocrine Hormones in Patients with Bipolar Disorder
title_full	A Retrospective Study of the Effects of Psychotropic Drugs on Neuroendocrine Hormones in Patients with Bipolar Disorder
title_fullStr	A Retrospective Study of the Effects of Psychotropic Drugs on Neuroendocrine Hormones in Patients with Bipolar Disorder
title_full_unstemmed	A Retrospective Study of the Effects of Psychotropic Drugs on Neuroendocrine Hormones in Patients with Bipolar Disorder
title_sort	retrospective study of the effects of psychotropic drugs on neuroendocrine hormones in patients with bipolar disorder
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/dc842d5c380841c28c09587a11d7093d
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A Retrospective Study of the Effects of Psychotropic Drugs on Neuroendocrine Hormones in Patients with Bipolar Disorder

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