Brown Fat as a Regulator of Systemic Metabolism beyond Thermogenesis

Brown adipose tissue (BAT) is a specialized tissue for nonshivering thermogenesis to dissipate energy as heat. Although BAT research has long been limited mostly in small rodents, the rediscovery of metabolically active BAT in adult humans has dramatically promoted the translational studies on BAT i...

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Autores principales:	Okamatsu-Ogura Yuko, Masayuki Saito
Formato:	article
Lenguaje:	EN
Publicado:	Korean Diabetes Association 2021
Materias:	adipocytes, beige adipose tissue adipose tissue, brown energy metabolism thermogenesis uncoupling protein 1 Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/dc848b6d81934871bf17fae84fc2c044
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id	oai:doaj.org-article:dc848b6d81934871bf17fae84fc2c044
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spelling	oai:doaj.org-article:dc848b6d81934871bf17fae84fc2c0442021-12-01T05:07:51ZBrown Fat as a Regulator of Systemic Metabolism beyond Thermogenesis2233-60792233-608710.4093/dmj.2020.0291https://doaj.org/article/dc848b6d81934871bf17fae84fc2c0442021-11-01T00:00:00Zhttp://www.e-dmj.org/upload/pdf/dmj-2020-0291.pdfhttps://doaj.org/toc/2233-6079https://doaj.org/toc/2233-6087Brown adipose tissue (BAT) is a specialized tissue for nonshivering thermogenesis to dissipate energy as heat. Although BAT research has long been limited mostly in small rodents, the rediscovery of metabolically active BAT in adult humans has dramatically promoted the translational studies on BAT in health and diseases. Moreover, several remarkable advancements have been made in brown fat biology over the past decade: The molecular and functional analyses of inducible thermogenic adipocytes (socalled beige adipocytes) arising from a developmentally different lineage from classical brown adipocytes have been accelerated. In addition to a well-established thermogenic activity of uncoupling protein 1 (UCP1), several alternative thermogenic mechanisms have been discovered, particularly in beige adipocytes. It has become clear that BAT influences other peripheral tissues and controls their functions and systemic homeostasis of energy and metabolic substrates, suggesting BAT as a metabolic regulator, other than for thermogenesis. This notion is supported by discovering that various paracrine and endocrine factors are secreted from BAT. We review the current understanding of BAT pathophysiology, particularly focusing on its role as a metabolic regulator in small rodents and also in humans.Okamatsu-Ogura YukoMasayuki SaitoKorean Diabetes Associationarticleadipocytes, beigeadipose tissueadipose tissue, brownenergy metabolismthermogenesisuncoupling protein 1Diseases of the endocrine glands. Clinical endocrinologyRC648-665ENDiabetes & Metabolism Journal, Vol 45, Iss 6, Pp 840-852 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	adipocytes, beige adipose tissue adipose tissue, brown energy metabolism thermogenesis uncoupling protein 1 Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	adipocytes, beige adipose tissue adipose tissue, brown energy metabolism thermogenesis uncoupling protein 1 Diseases of the endocrine glands. Clinical endocrinology RC648-665 Okamatsu-Ogura Yuko Masayuki Saito Brown Fat as a Regulator of Systemic Metabolism beyond Thermogenesis
description	Brown adipose tissue (BAT) is a specialized tissue for nonshivering thermogenesis to dissipate energy as heat. Although BAT research has long been limited mostly in small rodents, the rediscovery of metabolically active BAT in adult humans has dramatically promoted the translational studies on BAT in health and diseases. Moreover, several remarkable advancements have been made in brown fat biology over the past decade: The molecular and functional analyses of inducible thermogenic adipocytes (socalled beige adipocytes) arising from a developmentally different lineage from classical brown adipocytes have been accelerated. In addition to a well-established thermogenic activity of uncoupling protein 1 (UCP1), several alternative thermogenic mechanisms have been discovered, particularly in beige adipocytes. It has become clear that BAT influences other peripheral tissues and controls their functions and systemic homeostasis of energy and metabolic substrates, suggesting BAT as a metabolic regulator, other than for thermogenesis. This notion is supported by discovering that various paracrine and endocrine factors are secreted from BAT. We review the current understanding of BAT pathophysiology, particularly focusing on its role as a metabolic regulator in small rodents and also in humans.
format	article
author	Okamatsu-Ogura Yuko Masayuki Saito
author_facet	Okamatsu-Ogura Yuko Masayuki Saito
author_sort	Okamatsu-Ogura Yuko
title	Brown Fat as a Regulator of Systemic Metabolism beyond Thermogenesis
title_short	Brown Fat as a Regulator of Systemic Metabolism beyond Thermogenesis
title_full	Brown Fat as a Regulator of Systemic Metabolism beyond Thermogenesis
title_fullStr	Brown Fat as a Regulator of Systemic Metabolism beyond Thermogenesis
title_full_unstemmed	Brown Fat as a Regulator of Systemic Metabolism beyond Thermogenesis
title_sort	brown fat as a regulator of systemic metabolism beyond thermogenesis
publisher	Korean Diabetes Association
publishDate	2021
url	https://doaj.org/article/dc848b6d81934871bf17fae84fc2c044
work_keys_str_mv	AT okamatsuogurayuko brownfatasaregulatorofsystemicmetabolismbeyondthermogenesis AT masayukisaito brownfatasaregulatorofsystemicmetabolismbeyondthermogenesis
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Brown Fat as a Regulator of Systemic Metabolism beyond Thermogenesis

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