The burden of parasitic zoonoses in Nepal: a systematic review.

<h4>Background</h4>Parasitic zoonoses (PZs) pose a significant but often neglected threat to public health, especially in developing countries. In order to obtain a better understanding of their health impact, summary measures of population health may be calculated, such as the Disabilit...

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Autores principales: Brecht Devleesschauwer, Anita Ale, Paul Torgerson, Nicolas Praet, Charline Maertens de Noordhout, Basu Dev Pandey, Sher Bahadur Pun, Rob Lake, Jozef Vercruysse, Durga Datt Joshi, Arie H Havelaar, Luc Duchateau, Pierre Dorny, Niko Speybroeck
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spelling oai:doaj.org-article:dc8574ac984b4f2ab6b6d14ef7eba30a2021-11-18T09:16:31ZThe burden of parasitic zoonoses in Nepal: a systematic review.1935-27271935-273510.1371/journal.pntd.0002634https://doaj.org/article/dc8574ac984b4f2ab6b6d14ef7eba30a2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24392178/?tool=EBIhttps://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735<h4>Background</h4>Parasitic zoonoses (PZs) pose a significant but often neglected threat to public health, especially in developing countries. In order to obtain a better understanding of their health impact, summary measures of population health may be calculated, such as the Disability-Adjusted Life Year (DALY). However, the data required to calculate such measures are often not readily available for these diseases, which may lead to a vicious circle of under-recognition and under-funding.<h4>Methodology</h4>We examined the burden of PZs in Nepal through a systematic review of online and offline data sources. PZs were classified qualitatively according to endemicity, and where possible a quantitative burden assessment was conducted in terms of the annual number of incident cases, deaths and DALYs.<h4>Principal findings</h4>Between 2000 and 2012, the highest annual burden was imposed by neurocysticercosis and congenital toxoplasmosis (14,268 DALYs [95% Credibility Interval (CrI): 5450-27,694] and 9255 DALYs [95% CrI: 6135-13,292], respectively), followed by cystic echinococcosis (251 DALYs [95% CrI: 105-458]). Nepal is probably endemic for trichinellosis, toxocarosis, diphyllobothriosis, foodborne trematodosis, taeniosis, and zoonotic intestinal helminthic and protozoal infections, but insufficient data were available to quantify their health impact. Sporadic cases of alveolar echinococcosis, angiostrongylosis, capillariosis, dirofilariosis, gnathostomosis, sparganosis and cutaneous leishmaniosis may occur.<h4>Conclusions/significance</h4>In settings with limited surveillance capacity, it is possible to quantify the health impact of PZs and other neglected diseases, thereby interrupting the vicious circle of neglect. In Nepal, we found that several PZs are endemic and are imposing a significant burden to public health, higher than that of malaria, and comparable to that of HIV/AIDS. However, several critical data gaps remain. Enhanced surveillance for the endemic PZs identified in this study would enable additional burden estimates, and a more complete picture of the impact of these diseases.Brecht DevleesschauwerAnita AlePaul TorgersonNicolas PraetCharline Maertens de NoordhoutBasu Dev PandeySher Bahadur PunRob LakeJozef VercruysseDurga Datt JoshiArie H HavelaarLuc DuchateauPierre DornyNiko SpeybroeckPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 8, Iss 1, p e2634 (2014)
institution DOAJ
collection DOAJ
language EN
topic Arctic medicine. Tropical medicine
RC955-962
Public aspects of medicine
RA1-1270
spellingShingle Arctic medicine. Tropical medicine
RC955-962
Public aspects of medicine
RA1-1270
Brecht Devleesschauwer
Anita Ale
Paul Torgerson
Nicolas Praet
Charline Maertens de Noordhout
Basu Dev Pandey
Sher Bahadur Pun
Rob Lake
Jozef Vercruysse
Durga Datt Joshi
Arie H Havelaar
Luc Duchateau
Pierre Dorny
Niko Speybroeck
The burden of parasitic zoonoses in Nepal: a systematic review.
description <h4>Background</h4>Parasitic zoonoses (PZs) pose a significant but often neglected threat to public health, especially in developing countries. In order to obtain a better understanding of their health impact, summary measures of population health may be calculated, such as the Disability-Adjusted Life Year (DALY). However, the data required to calculate such measures are often not readily available for these diseases, which may lead to a vicious circle of under-recognition and under-funding.<h4>Methodology</h4>We examined the burden of PZs in Nepal through a systematic review of online and offline data sources. PZs were classified qualitatively according to endemicity, and where possible a quantitative burden assessment was conducted in terms of the annual number of incident cases, deaths and DALYs.<h4>Principal findings</h4>Between 2000 and 2012, the highest annual burden was imposed by neurocysticercosis and congenital toxoplasmosis (14,268 DALYs [95% Credibility Interval (CrI): 5450-27,694] and 9255 DALYs [95% CrI: 6135-13,292], respectively), followed by cystic echinococcosis (251 DALYs [95% CrI: 105-458]). Nepal is probably endemic for trichinellosis, toxocarosis, diphyllobothriosis, foodborne trematodosis, taeniosis, and zoonotic intestinal helminthic and protozoal infections, but insufficient data were available to quantify their health impact. Sporadic cases of alveolar echinococcosis, angiostrongylosis, capillariosis, dirofilariosis, gnathostomosis, sparganosis and cutaneous leishmaniosis may occur.<h4>Conclusions/significance</h4>In settings with limited surveillance capacity, it is possible to quantify the health impact of PZs and other neglected diseases, thereby interrupting the vicious circle of neglect. In Nepal, we found that several PZs are endemic and are imposing a significant burden to public health, higher than that of malaria, and comparable to that of HIV/AIDS. However, several critical data gaps remain. Enhanced surveillance for the endemic PZs identified in this study would enable additional burden estimates, and a more complete picture of the impact of these diseases.
format article
author Brecht Devleesschauwer
Anita Ale
Paul Torgerson
Nicolas Praet
Charline Maertens de Noordhout
Basu Dev Pandey
Sher Bahadur Pun
Rob Lake
Jozef Vercruysse
Durga Datt Joshi
Arie H Havelaar
Luc Duchateau
Pierre Dorny
Niko Speybroeck
author_facet Brecht Devleesschauwer
Anita Ale
Paul Torgerson
Nicolas Praet
Charline Maertens de Noordhout
Basu Dev Pandey
Sher Bahadur Pun
Rob Lake
Jozef Vercruysse
Durga Datt Joshi
Arie H Havelaar
Luc Duchateau
Pierre Dorny
Niko Speybroeck
author_sort Brecht Devleesschauwer
title The burden of parasitic zoonoses in Nepal: a systematic review.
title_short The burden of parasitic zoonoses in Nepal: a systematic review.
title_full The burden of parasitic zoonoses in Nepal: a systematic review.
title_fullStr The burden of parasitic zoonoses in Nepal: a systematic review.
title_full_unstemmed The burden of parasitic zoonoses in Nepal: a systematic review.
title_sort burden of parasitic zoonoses in nepal: a systematic review.
publisher Public Library of Science (PLoS)
publishDate 2014
url https://doaj.org/article/dc8574ac984b4f2ab6b6d14ef7eba30a
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