Synthesis of biocompatible iron oxide nanoparticles as a drug delivery vehicle

Krupa Kansara, Pal Patel, Ritesh K Shukla, Alok Pandya, Rishi Shanker, Ashutosh Kumar, Alok Dhawan Institute of Life Sciences, School of Science and Technology, Ahmedabad University, Ahmedabad, Gujarat, India Abstract: Over the last decade, there has been growing interest in developing novel nanop...

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Autores principales:	Kansara K, Patel P, Shukla RK, Pandya A, Shanker R, Kumar A, Dhawan A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Biocompatible Iron Oxide nanoparticles human breast adenocarcinoma cells Co-precipitation Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/dc8ddd731d144cf985bb95d8e8546bef
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spelling	oai:doaj.org-article:dc8ddd731d144cf985bb95d8e8546bef2021-12-02T07:45:56ZSynthesis of biocompatible iron oxide nanoparticles as a drug delivery vehicle1178-2013https://doaj.org/article/dc8ddd731d144cf985bb95d8e8546bef2018-03-01T00:00:00Zhttps://www.dovepress.com/synthesis-of-biocompatible-iron-oxide-nanoparticles-as-a-drug-delivery-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Krupa Kansara, Pal Patel, Ritesh K Shukla, Alok Pandya, Rishi Shanker, Ashutosh Kumar, Alok Dhawan Institute of Life Sciences, School of Science and Technology, Ahmedabad University, Ahmedabad, Gujarat, India Abstract: Over the last decade, there has been growing interest in developing novel nanoparticles (NPs) for biomedical applications. A safe-by-design approach was used in this study to synthesize biocompatible iron oxide NPs. The size of the particles obtained was ~100 nm. Although these NPs were significantly (P<0.05) internalized in MCF-7 (human breast adenocarcinoma cell line) cells, no adverse effect was observed in the cells as assessed by cytotoxicity assays (neutral red uptake and 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) and cell cycle analysis. Our data demonstrate the potential of iron oxide NPs as a biocompatible carrier for targeted drug delivery. Keywords: biocompatible iron oxide nanoparticles, human breast adenocarcinoma cells, coprecipitationKansara KPatel PShukla RKPandya AShanker RKumar ADhawan ADove Medical PressarticleBiocompatible Iron Oxide nanoparticleshuman breast adenocarcinoma cellsCo-precipitationMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 79-82 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biocompatible Iron Oxide nanoparticles human breast adenocarcinoma cells Co-precipitation Medicine (General) R5-920
spellingShingle	Biocompatible Iron Oxide nanoparticles human breast adenocarcinoma cells Co-precipitation Medicine (General) R5-920 Kansara K Patel P Shukla RK Pandya A Shanker R Kumar A Dhawan A Synthesis of biocompatible iron oxide nanoparticles as a drug delivery vehicle
description	Krupa Kansara, Pal Patel, Ritesh K Shukla, Alok Pandya, Rishi Shanker, Ashutosh Kumar, Alok Dhawan Institute of Life Sciences, School of Science and Technology, Ahmedabad University, Ahmedabad, Gujarat, India Abstract: Over the last decade, there has been growing interest in developing novel nanoparticles (NPs) for biomedical applications. A safe-by-design approach was used in this study to synthesize biocompatible iron oxide NPs. The size of the particles obtained was ~100 nm. Although these NPs were significantly (P<0.05) internalized in MCF-7 (human breast adenocarcinoma cell line) cells, no adverse effect was observed in the cells as assessed by cytotoxicity assays (neutral red uptake and 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) and cell cycle analysis. Our data demonstrate the potential of iron oxide NPs as a biocompatible carrier for targeted drug delivery. Keywords: biocompatible iron oxide nanoparticles, human breast adenocarcinoma cells, coprecipitation
format	article
author	Kansara K Patel P Shukla RK Pandya A Shanker R Kumar A Dhawan A
author_facet	Kansara K Patel P Shukla RK Pandya A Shanker R Kumar A Dhawan A
author_sort	Kansara K
title	Synthesis of biocompatible iron oxide nanoparticles as a drug delivery vehicle
title_short	Synthesis of biocompatible iron oxide nanoparticles as a drug delivery vehicle
title_full	Synthesis of biocompatible iron oxide nanoparticles as a drug delivery vehicle
title_fullStr	Synthesis of biocompatible iron oxide nanoparticles as a drug delivery vehicle
title_full_unstemmed	Synthesis of biocompatible iron oxide nanoparticles as a drug delivery vehicle
title_sort	synthesis of biocompatible iron oxide nanoparticles as a drug delivery vehicle
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/dc8ddd731d144cf985bb95d8e8546bef
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Synthesis of biocompatible iron oxide nanoparticles as a drug delivery vehicle

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