Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity

Senolytics have the potential to extend healthspan by selectively killing senescent cells (SCs), but senolytics that target Bcl-xl may cause platelet toxicity. Here, the authors generated a Bcl-xl proteolysis-targeting chimera (PROTAC) senolytic, which effectively clears SCs and rejuvenates tissue s...

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Autores principales:	Yonghan He, Xuan Zhang, Jianhui Chang, Ha-Neui Kim, Peiyi Zhang, Yingying Wang, Sajid Khan, Xingui Liu, Xin Zhang, Dongwen Lv, Lin Song, Wen Li, Dinesh Thummuri, Yaxia Yuan, Janet S. Wiegand, Yuma T. Ortiz, Vivekananda Budamagunta, Jennifer H. Elisseeff, Judith Campisi, Maria Almeida, Guangrong Zheng, Daohong Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dc8e747a1c2b46fbb1cf6eb91566a85f
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spelling	oai:doaj.org-article:dc8e747a1c2b46fbb1cf6eb91566a85f2021-12-02T14:41:05ZUsing proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity10.1038/s41467-020-15838-02041-1723https://doaj.org/article/dc8e747a1c2b46fbb1cf6eb91566a85f2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15838-0https://doaj.org/toc/2041-1723Senolytics have the potential to extend healthspan by selectively killing senescent cells (SCs), but senolytics that target Bcl-xl may cause platelet toxicity. Here, the authors generated a Bcl-xl proteolysis-targeting chimera (PROTAC) senolytic, which effectively clears SCs and rejuvenates tissue stem and progenitor cells in naturally aged mice without causing severe thrombocytopenia.Yonghan HeXuan ZhangJianhui ChangHa-Neui KimPeiyi ZhangYingying WangSajid KhanXingui LiuXin ZhangDongwen LvLin SongWen LiDinesh ThummuriYaxia YuanJanet S. WiegandYuma T. OrtizVivekananda BudamaguntaJennifer H. ElisseeffJudith CampisiMaria AlmeidaGuangrong ZhengDaohong ZhouNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yonghan He Xuan Zhang Jianhui Chang Ha-Neui Kim Peiyi Zhang Yingying Wang Sajid Khan Xingui Liu Xin Zhang Dongwen Lv Lin Song Wen Li Dinesh Thummuri Yaxia Yuan Janet S. Wiegand Yuma T. Ortiz Vivekananda Budamagunta Jennifer H. Elisseeff Judith Campisi Maria Almeida Guangrong Zheng Daohong Zhou Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity
description	Senolytics have the potential to extend healthspan by selectively killing senescent cells (SCs), but senolytics that target Bcl-xl may cause platelet toxicity. Here, the authors generated a Bcl-xl proteolysis-targeting chimera (PROTAC) senolytic, which effectively clears SCs and rejuvenates tissue stem and progenitor cells in naturally aged mice without causing severe thrombocytopenia.
format	article
author	Yonghan He Xuan Zhang Jianhui Chang Ha-Neui Kim Peiyi Zhang Yingying Wang Sajid Khan Xingui Liu Xin Zhang Dongwen Lv Lin Song Wen Li Dinesh Thummuri Yaxia Yuan Janet S. Wiegand Yuma T. Ortiz Vivekananda Budamagunta Jennifer H. Elisseeff Judith Campisi Maria Almeida Guangrong Zheng Daohong Zhou
author_facet	Yonghan He Xuan Zhang Jianhui Chang Ha-Neui Kim Peiyi Zhang Yingying Wang Sajid Khan Xingui Liu Xin Zhang Dongwen Lv Lin Song Wen Li Dinesh Thummuri Yaxia Yuan Janet S. Wiegand Yuma T. Ortiz Vivekananda Budamagunta Jennifer H. Elisseeff Judith Campisi Maria Almeida Guangrong Zheng Daohong Zhou
author_sort	Yonghan He
title	Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity
title_short	Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity
title_full	Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity
title_fullStr	Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity
title_full_unstemmed	Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity
title_sort	using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/dc8e747a1c2b46fbb1cf6eb91566a85f
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Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity

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