Contralateral S1 function is involved in electroacupuncture treatment-mediated recovery after focal unilateral M1 infarction

Acupuncture at acupoints Baihui (GV20) and Dazhui (GV14) has been shown to promote functional recovery after stroke. However, the contribution of the contralateral primary sensory cortex (S1) to recovery remains unclear. In this study, unilateral local ischemic infarction of the primary motor cortex...

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Autores principales:	Lu-Lu Yao, Si Yuan, Zhen-Nan Wu, Jian-Yu Luo, Xiao-Rong Tang, Chun-Zhi Tang, Shuai Cui, Neng-Gui Xu
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2022
Materias:	brain plasticity; electroacupuncture; electrophysiology recording; neuronal activity; primary motor cortex; primary sensory cortex; stroke Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/dc8f594e04df46a59342639f3168564f
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spelling	oai:doaj.org-article:dc8f594e04df46a59342639f3168564f2021-11-19T12:16:44ZContralateral S1 function is involved in electroacupuncture treatment-mediated recovery after focal unilateral M1 infarction1673-537410.4103/1673-5374.327355https://doaj.org/article/dc8f594e04df46a59342639f3168564f2022-01-01T00:00:00Zhttp://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=6;spage=1310;epage=1317;aulast=Yaohttps://doaj.org/toc/1673-5374Acupuncture at acupoints Baihui (GV20) and Dazhui (GV14) has been shown to promote functional recovery after stroke. However, the contribution of the contralateral primary sensory cortex (S1) to recovery remains unclear. In this study, unilateral local ischemic infarction of the primary motor cortex (M1) was induced by photothrombosis in a mouse model. Electroacupuncture (EA) was subsequently performed at acupoints GV20 and GV14 and neuronal activity and functional connectivity of contralateral S1 and M1 were detected using in vivo and in vitro electrophysiological recording techniques. Our results showed that blood perfusion and neuronal interaction between contralateral M1 and S1 is impaired after unilateral M1 infarction. Intrinsic neuronal excitability and activity were also disturbed, which was rescued by EA. Furthermore, the effectiveness of EA treatment was inhibited after virus-mediated neuronal ablation of the contralateral S1. We conclude that neuronal activity of the contralateral S1 is important for EA-mediated recovery after focal M1 infarction. Our study provides insight into how the S1–M1 circuit might be involved in the mechanism of EA treatment of unilateral cerebral infarction. The animal experiments were approved by the Committee for Care and Use of Research Animals of Guangzhou University of Chinese Medicine (approval No. 20200407009) April 7, 2020.Lu-Lu YaoSi YuanZhen-Nan WuJian-Yu LuoXiao-Rong TangChun-Zhi TangShuai CuiNeng-Gui XuWolters Kluwer Medknow Publicationsarticlebrain plasticity; electroacupuncture; electrophysiology recording; neuronal activity; primary motor cortex; primary sensory cortex; strokeNeurology. Diseases of the nervous systemRC346-429ENNeural Regeneration Research, Vol 17, Iss 6, Pp 1310-1317 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	brain plasticity; electroacupuncture; electrophysiology recording; neuronal activity; primary motor cortex; primary sensory cortex; stroke Neurology. Diseases of the nervous system RC346-429
spellingShingle	brain plasticity; electroacupuncture; electrophysiology recording; neuronal activity; primary motor cortex; primary sensory cortex; stroke Neurology. Diseases of the nervous system RC346-429 Lu-Lu Yao Si Yuan Zhen-Nan Wu Jian-Yu Luo Xiao-Rong Tang Chun-Zhi Tang Shuai Cui Neng-Gui Xu Contralateral S1 function is involved in electroacupuncture treatment-mediated recovery after focal unilateral M1 infarction
description	Acupuncture at acupoints Baihui (GV20) and Dazhui (GV14) has been shown to promote functional recovery after stroke. However, the contribution of the contralateral primary sensory cortex (S1) to recovery remains unclear. In this study, unilateral local ischemic infarction of the primary motor cortex (M1) was induced by photothrombosis in a mouse model. Electroacupuncture (EA) was subsequently performed at acupoints GV20 and GV14 and neuronal activity and functional connectivity of contralateral S1 and M1 were detected using in vivo and in vitro electrophysiological recording techniques. Our results showed that blood perfusion and neuronal interaction between contralateral M1 and S1 is impaired after unilateral M1 infarction. Intrinsic neuronal excitability and activity were also disturbed, which was rescued by EA. Furthermore, the effectiveness of EA treatment was inhibited after virus-mediated neuronal ablation of the contralateral S1. We conclude that neuronal activity of the contralateral S1 is important for EA-mediated recovery after focal M1 infarction. Our study provides insight into how the S1–M1 circuit might be involved in the mechanism of EA treatment of unilateral cerebral infarction. The animal experiments were approved by the Committee for Care and Use of Research Animals of Guangzhou University of Chinese Medicine (approval No. 20200407009) April 7, 2020.
format	article
author	Lu-Lu Yao Si Yuan Zhen-Nan Wu Jian-Yu Luo Xiao-Rong Tang Chun-Zhi Tang Shuai Cui Neng-Gui Xu
author_facet	Lu-Lu Yao Si Yuan Zhen-Nan Wu Jian-Yu Luo Xiao-Rong Tang Chun-Zhi Tang Shuai Cui Neng-Gui Xu
author_sort	Lu-Lu Yao
title	Contralateral S1 function is involved in electroacupuncture treatment-mediated recovery after focal unilateral M1 infarction
title_short	Contralateral S1 function is involved in electroacupuncture treatment-mediated recovery after focal unilateral M1 infarction
title_full	Contralateral S1 function is involved in electroacupuncture treatment-mediated recovery after focal unilateral M1 infarction
title_fullStr	Contralateral S1 function is involved in electroacupuncture treatment-mediated recovery after focal unilateral M1 infarction
title_full_unstemmed	Contralateral S1 function is involved in electroacupuncture treatment-mediated recovery after focal unilateral M1 infarction
title_sort	contralateral s1 function is involved in electroacupuncture treatment-mediated recovery after focal unilateral m1 infarction
publisher	Wolters Kluwer Medknow Publications
publishDate	2022
url	https://doaj.org/article/dc8f594e04df46a59342639f3168564f
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Contralateral S1 function is involved in electroacupuncture treatment-mediated recovery after focal unilateral M1 infarction

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