p38γ and δ promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation

mTOR signalling pathway is a critical regulator of cardiac hypertrophy. Here the authors show that two kinases, p38γ and p38δ, control heart growth by promoting mTOR activity via phosphorylation and consequent proteasome degradation of mTOR inhibitor DEPTOR, extending our knowledge of cardiac hypert...

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Autores principales:	Bárbara González-Terán, Juan Antonio López, Elena Rodríguez, Luis Leiva, Sara Martínez-Martínez, Juan Antonio Bernal, Luis Jesús Jiménez-Borreguero, Juan Miguel Redondo, Jesús Vazquez, Guadalupe Sabio
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dc9094845db94cc38fe281710e660725
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spelling	oai:doaj.org-article:dc9094845db94cc38fe281710e6607252021-12-02T16:49:41Zp38γ and δ promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation10.1038/ncomms104772041-1723https://doaj.org/article/dc9094845db94cc38fe281710e6607252016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10477https://doaj.org/toc/2041-1723mTOR signalling pathway is a critical regulator of cardiac hypertrophy. Here the authors show that two kinases, p38γ and p38δ, control heart growth by promoting mTOR activity via phosphorylation and consequent proteasome degradation of mTOR inhibitor DEPTOR, extending our knowledge of cardiac hypertrophy regulation.Bárbara González-TeránJuan Antonio LópezElena RodríguezLuis LeivaSara Martínez-MartínezJuan Antonio BernalLuis Jesús Jiménez-BorregueroJuan Miguel RedondoJesús VazquezGuadalupe SabioNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bárbara González-Terán Juan Antonio López Elena Rodríguez Luis Leiva Sara Martínez-Martínez Juan Antonio Bernal Luis Jesús Jiménez-Borreguero Juan Miguel Redondo Jesús Vazquez Guadalupe Sabio p38γ and δ promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation
description	mTOR signalling pathway is a critical regulator of cardiac hypertrophy. Here the authors show that two kinases, p38γ and p38δ, control heart growth by promoting mTOR activity via phosphorylation and consequent proteasome degradation of mTOR inhibitor DEPTOR, extending our knowledge of cardiac hypertrophy regulation.
format	article
author	Bárbara González-Terán Juan Antonio López Elena Rodríguez Luis Leiva Sara Martínez-Martínez Juan Antonio Bernal Luis Jesús Jiménez-Borreguero Juan Miguel Redondo Jesús Vazquez Guadalupe Sabio
author_facet	Bárbara González-Terán Juan Antonio López Elena Rodríguez Luis Leiva Sara Martínez-Martínez Juan Antonio Bernal Luis Jesús Jiménez-Borreguero Juan Miguel Redondo Jesús Vazquez Guadalupe Sabio
author_sort	Bárbara González-Terán
title	p38γ and δ promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation
title_short	p38γ and δ promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation
title_full	p38γ and δ promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation
title_fullStr	p38γ and δ promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation
title_full_unstemmed	p38γ and δ promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation
title_sort	p38γ and δ promote heart hypertrophy by targeting the mtor-inhibitory protein deptor for degradation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/dc9094845db94cc38fe281710e660725
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p38γ and δ promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation

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