Blocking HMGB1/RAGE Signaling by Berberine Alleviates A1 Astrocyte and Attenuates Sepsis-Associated Encephalopathy

As a life-threatening multiple organ dysfunction attributable to maladjusted host immune responses to infection, sepsis is usually the common pathway to serious prognosis and death for numerous infectious diseases all over the world. Sepsis-associated encephalopathy (SAE) is frequently complicated b...

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Autores principales:	Jian Shi, Huan Xu, María José Cavagnaro, Xingmei Li, Jia Fang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	berberine sepsis-associated encephalopathy HMGB1/RAGE signaling cognitive impairment inflammatory cytokines neuropharmacology Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/dc941ff61a674ed7b05176ef9904331b
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spelling	oai:doaj.org-article:dc941ff61a674ed7b05176ef9904331b2021-11-15T05:57:58ZBlocking HMGB1/RAGE Signaling by Berberine Alleviates A1 Astrocyte and Attenuates Sepsis-Associated Encephalopathy1663-981210.3389/fphar.2021.760186https://doaj.org/article/dc941ff61a674ed7b05176ef9904331b2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.760186/fullhttps://doaj.org/toc/1663-9812As a life-threatening multiple organ dysfunction attributable to maladjusted host immune responses to infection, sepsis is usually the common pathway to serious prognosis and death for numerous infectious diseases all over the world. Sepsis-associated encephalopathy (SAE) is frequently complicated by septic conditions, and is one of the most important reasons for increased mortality and poor outcomes in septic patients which is still an urgent clinical problem need to be solved. In this research, a conspicuously discovery of treatment-related translational use for berberine was elaborated. The results revealed that berberine treatment significantly restored cognitive impairment in sepsis mice. Reduced expression levels of TNF-α, IL-1α, and C1qA were exhibited in the hippocampus of the berberine treatment group, and attenuated effect of declining neo-neuron, activation of microglia and astrocytes in the hippocampus of mice with sepsis were also found. Moreover, berberine inhibits microglia-stressed A1 astrocytes by inhibiting HMGB1 signaling was revealed, then the molecular mechanism of HMGB1/RAGE signaling inhibition leads to the better outcome of SAE was elucidated. To summarize, this research indicated that berberine targets HMGB1/RAGE signaling to inhibit microglia-stressed A1 astrocyte and neo-neuron decline, which consequently alleviates sepsis-induced cognitive impairment. Collectively, berberine may serve as potential therapeutic drug and HMGB1/RAGE signaling would be a novel target for medicine development for treating SAE.Jian ShiJian ShiHuan XuMaría José CavagnaroXingmei LiXingmei LiJia FangFrontiers Media S.A.articleberberinesepsis-associated encephalopathyHMGB1/RAGE signalingcognitive impairmentinflammatory cytokinesneuropharmacologyTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	berberine sepsis-associated encephalopathy HMGB1/RAGE signaling cognitive impairment inflammatory cytokines neuropharmacology Therapeutics. Pharmacology RM1-950
spellingShingle	berberine sepsis-associated encephalopathy HMGB1/RAGE signaling cognitive impairment inflammatory cytokines neuropharmacology Therapeutics. Pharmacology RM1-950 Jian Shi Jian Shi Huan Xu María José Cavagnaro Xingmei Li Xingmei Li Jia Fang Blocking HMGB1/RAGE Signaling by Berberine Alleviates A1 Astrocyte and Attenuates Sepsis-Associated Encephalopathy
description	As a life-threatening multiple organ dysfunction attributable to maladjusted host immune responses to infection, sepsis is usually the common pathway to serious prognosis and death for numerous infectious diseases all over the world. Sepsis-associated encephalopathy (SAE) is frequently complicated by septic conditions, and is one of the most important reasons for increased mortality and poor outcomes in septic patients which is still an urgent clinical problem need to be solved. In this research, a conspicuously discovery of treatment-related translational use for berberine was elaborated. The results revealed that berberine treatment significantly restored cognitive impairment in sepsis mice. Reduced expression levels of TNF-α, IL-1α, and C1qA were exhibited in the hippocampus of the berberine treatment group, and attenuated effect of declining neo-neuron, activation of microglia and astrocytes in the hippocampus of mice with sepsis were also found. Moreover, berberine inhibits microglia-stressed A1 astrocytes by inhibiting HMGB1 signaling was revealed, then the molecular mechanism of HMGB1/RAGE signaling inhibition leads to the better outcome of SAE was elucidated. To summarize, this research indicated that berberine targets HMGB1/RAGE signaling to inhibit microglia-stressed A1 astrocyte and neo-neuron decline, which consequently alleviates sepsis-induced cognitive impairment. Collectively, berberine may serve as potential therapeutic drug and HMGB1/RAGE signaling would be a novel target for medicine development for treating SAE.
format	article
author	Jian Shi Jian Shi Huan Xu María José Cavagnaro Xingmei Li Xingmei Li Jia Fang
author_facet	Jian Shi Jian Shi Huan Xu María José Cavagnaro Xingmei Li Xingmei Li Jia Fang
author_sort	Jian Shi
title	Blocking HMGB1/RAGE Signaling by Berberine Alleviates A1 Astrocyte and Attenuates Sepsis-Associated Encephalopathy
title_short	Blocking HMGB1/RAGE Signaling by Berberine Alleviates A1 Astrocyte and Attenuates Sepsis-Associated Encephalopathy
title_full	Blocking HMGB1/RAGE Signaling by Berberine Alleviates A1 Astrocyte and Attenuates Sepsis-Associated Encephalopathy
title_fullStr	Blocking HMGB1/RAGE Signaling by Berberine Alleviates A1 Astrocyte and Attenuates Sepsis-Associated Encephalopathy
title_full_unstemmed	Blocking HMGB1/RAGE Signaling by Berberine Alleviates A1 Astrocyte and Attenuates Sepsis-Associated Encephalopathy
title_sort	blocking hmgb1/rage signaling by berberine alleviates a1 astrocyte and attenuates sepsis-associated encephalopathy
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/dc941ff61a674ed7b05176ef9904331b
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Blocking HMGB1/RAGE Signaling by Berberine Alleviates A1 Astrocyte and Attenuates Sepsis-Associated Encephalopathy

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