NEUROLOGICAL MANIFESTATIONS OF GLUTEN RELATED DISORDERS

Objective: To determine the frequency and pattern of neurological features in patients diagnosed with gluten related disorder (GRD). Study Design: Cross sectional analytical study. Place and Duration of Study: Pak Emirates Military Hospital Rawalpindi, from Jan 2016 to Jun 2018. Patients an...

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Autores principales:	Asif Hashmat, Saeed Arif, Jahanzeb Liaqat, Wasim Wali Muhammad, Wasim Alamgir
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2019
Materias:	anti gliadin antibodies coeliac disease gluten sensitivity Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/dc94ab9fa9e840c580410d69b69ef1c5
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spelling	oai:doaj.org-article:dc94ab9fa9e840c580410d69b69ef1c52021-11-11T03:28:24ZNEUROLOGICAL MANIFESTATIONS OF GLUTEN RELATED DISORDERS0030-96482411-8842https://doaj.org/article/dc94ab9fa9e840c580410d69b69ef1c52019-08-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/3198/2307https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To determine the frequency and pattern of neurological features in patients diagnosed with gluten related disorder (GRD). Study Design: Cross sectional analytical study. Place and Duration of Study: Pak Emirates Military Hospital Rawalpindi, from Jan 2016 to Jun 2018. Patients and Methods: This study included cases who presented initially with neurological manifestations and later diagnosed having GRD, including coeliac disease (CD) or non-coeliac gluten sensitivity (NCGS). Cases fulfilling inclusion and exclusion criteria were selected. Record of patients was obtained from the hospital stats office. Cases were analyzed for clinical symptomatology, laboratory and neuro-radiological findings. Data was collected using performa and analysis was done using SPSS version 20. Results: Out of 31 patients, 18 (58.1%) were male and 13 (49.9%) were females. Mean age was 28.8 ± 10.4 years. Nineteen (61.3%) were diagnosed with CD while 12 (38.7%) had NCGS. Anti-TTG antibodies were detected in 17 out of 19 patients with CD, while anti Gliadin antibodies were positive in 11 out of 12 patients with NCGS. These results were statistically significant with p-value <0.001. Headache was the commonest manifestation in GRD, in 17 (54.8%) patients while 11 (34.5%) had seizures. Six cases (19.3%) presented with variable generalized weakness. Moreover 10 (32.2%) patients had MRI brain abnormalities. Conclusion: CD and NCGS should be kept in differential diagnosis, in various central and peripheral nervous system clinical manifestations. Moreover even if biopsy is negative for CD even then gluten sensitivity can be present in the form of NCGS with neurological manifestations.Asif HashmatSaeed ArifJahanzeb LiaqatWasim Wali MuhammadWasim AlamgirArmy Medical College Rawalpindiarticleanti gliadin antibodiescoeliac diseasegluten sensitivityMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 69, Iss 4, Pp 774-778 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	anti gliadin antibodies coeliac disease gluten sensitivity Medicine R Medicine (General) R5-920
spellingShingle	anti gliadin antibodies coeliac disease gluten sensitivity Medicine R Medicine (General) R5-920 Asif Hashmat Saeed Arif Jahanzeb Liaqat Wasim Wali Muhammad Wasim Alamgir NEUROLOGICAL MANIFESTATIONS OF GLUTEN RELATED DISORDERS
description	Objective: To determine the frequency and pattern of neurological features in patients diagnosed with gluten related disorder (GRD). Study Design: Cross sectional analytical study. Place and Duration of Study: Pak Emirates Military Hospital Rawalpindi, from Jan 2016 to Jun 2018. Patients and Methods: This study included cases who presented initially with neurological manifestations and later diagnosed having GRD, including coeliac disease (CD) or non-coeliac gluten sensitivity (NCGS). Cases fulfilling inclusion and exclusion criteria were selected. Record of patients was obtained from the hospital stats office. Cases were analyzed for clinical symptomatology, laboratory and neuro-radiological findings. Data was collected using performa and analysis was done using SPSS version 20. Results: Out of 31 patients, 18 (58.1%) were male and 13 (49.9%) were females. Mean age was 28.8 ± 10.4 years. Nineteen (61.3%) were diagnosed with CD while 12 (38.7%) had NCGS. Anti-TTG antibodies were detected in 17 out of 19 patients with CD, while anti Gliadin antibodies were positive in 11 out of 12 patients with NCGS. These results were statistically significant with p-value <0.001. Headache was the commonest manifestation in GRD, in 17 (54.8%) patients while 11 (34.5%) had seizures. Six cases (19.3%) presented with variable generalized weakness. Moreover 10 (32.2%) patients had MRI brain abnormalities. Conclusion: CD and NCGS should be kept in differential diagnosis, in various central and peripheral nervous system clinical manifestations. Moreover even if biopsy is negative for CD even then gluten sensitivity can be present in the form of NCGS with neurological manifestations.
format	article
author	Asif Hashmat Saeed Arif Jahanzeb Liaqat Wasim Wali Muhammad Wasim Alamgir
author_facet	Asif Hashmat Saeed Arif Jahanzeb Liaqat Wasim Wali Muhammad Wasim Alamgir
author_sort	Asif Hashmat
title	NEUROLOGICAL MANIFESTATIONS OF GLUTEN RELATED DISORDERS
title_short	NEUROLOGICAL MANIFESTATIONS OF GLUTEN RELATED DISORDERS
title_full	NEUROLOGICAL MANIFESTATIONS OF GLUTEN RELATED DISORDERS
title_fullStr	NEUROLOGICAL MANIFESTATIONS OF GLUTEN RELATED DISORDERS
title_full_unstemmed	NEUROLOGICAL MANIFESTATIONS OF GLUTEN RELATED DISORDERS
title_sort	neurological manifestations of gluten related disorders
publisher	Army Medical College Rawalpindi
publishDate	2019
url	https://doaj.org/article/dc94ab9fa9e840c580410d69b69ef1c5
work_keys_str_mv	AT asifhashmat neurologicalmanifestationsofglutenrelateddisorders AT saeedarif neurologicalmanifestationsofglutenrelateddisorders AT jahanzebliaqat neurologicalmanifestationsofglutenrelateddisorders AT wasimwalimuhammad neurologicalmanifestationsofglutenrelateddisorders AT wasimalamgir neurologicalmanifestationsofglutenrelateddisorders
_version_	1718439635822051328

NEUROLOGICAL MANIFESTATIONS OF GLUTEN RELATED DISORDERS

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