Non-flipping DNA glycosylase AlkD scans DNA without formation of a stable interrogation complex

Ahmadi et al. use a single-molecule tracking method to describe the DNA scanning mode of AlkD, a HEAT-like repeat DNA glycosylase. They show that, contrary to other glycosylases that use a base-flipping mechanism, AlkD scans the DNA without forming a stable interrogation complex.

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Autores principales:	Arash Ahmadi, Katharina Till, Paul Hoff Backe, Pernille Blicher, Robin Diekmann, Mark Schüttpelz, Kyrre Glette, Jim Tørresen, Magnar Bjørås, Alexander D. Rowe, Bjørn Dalhus
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/dc979ac48443432c9defb5314d98f0c6
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spelling	oai:doaj.org-article:dc979ac48443432c9defb5314d98f0c62021-12-02T18:30:44ZNon-flipping DNA glycosylase AlkD scans DNA without formation of a stable interrogation complex10.1038/s42003-021-02400-x2399-3642https://doaj.org/article/dc979ac48443432c9defb5314d98f0c62021-07-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02400-xhttps://doaj.org/toc/2399-3642Ahmadi et al. use a single-molecule tracking method to describe the DNA scanning mode of AlkD, a HEAT-like repeat DNA glycosylase. They show that, contrary to other glycosylases that use a base-flipping mechanism, AlkD scans the DNA without forming a stable interrogation complex.Arash AhmadiKatharina TillPaul Hoff BackePernille BlicherRobin DiekmannMark SchüttpelzKyrre GletteJim TørresenMagnar BjøråsAlexander D. RoweBjørn DalhusNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Arash Ahmadi Katharina Till Paul Hoff Backe Pernille Blicher Robin Diekmann Mark Schüttpelz Kyrre Glette Jim Tørresen Magnar Bjørås Alexander D. Rowe Bjørn Dalhus Non-flipping DNA glycosylase AlkD scans DNA without formation of a stable interrogation complex
description	Ahmadi et al. use a single-molecule tracking method to describe the DNA scanning mode of AlkD, a HEAT-like repeat DNA glycosylase. They show that, contrary to other glycosylases that use a base-flipping mechanism, AlkD scans the DNA without forming a stable interrogation complex.
format	article
author	Arash Ahmadi Katharina Till Paul Hoff Backe Pernille Blicher Robin Diekmann Mark Schüttpelz Kyrre Glette Jim Tørresen Magnar Bjørås Alexander D. Rowe Bjørn Dalhus
author_facet	Arash Ahmadi Katharina Till Paul Hoff Backe Pernille Blicher Robin Diekmann Mark Schüttpelz Kyrre Glette Jim Tørresen Magnar Bjørås Alexander D. Rowe Bjørn Dalhus
author_sort	Arash Ahmadi
title	Non-flipping DNA glycosylase AlkD scans DNA without formation of a stable interrogation complex
title_short	Non-flipping DNA glycosylase AlkD scans DNA without formation of a stable interrogation complex
title_full	Non-flipping DNA glycosylase AlkD scans DNA without formation of a stable interrogation complex
title_fullStr	Non-flipping DNA glycosylase AlkD scans DNA without formation of a stable interrogation complex
title_full_unstemmed	Non-flipping DNA glycosylase AlkD scans DNA without formation of a stable interrogation complex
title_sort	non-flipping dna glycosylase alkd scans dna without formation of a stable interrogation complex
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dc979ac48443432c9defb5314d98f0c6
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Non-flipping DNA glycosylase AlkD scans DNA without formation of a stable interrogation complex

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