A new congenital cleft palate New Zealand rabbit model for surgical research

Abstract Cleft palate repair is a challenging procedure for cleft surgeons to teach, and in research, it can be difficult to evaluate different techniques and develop new treatments. In this study, a congenital cleft palate New Zealand rabbit model has been described and could be beneficial in futur...

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Autores principales:	Haoyue Liu, Lingling Pu, Chialing Tsauo, Xiaoming Wang, Qian Zheng, Bing Shi, Chenghao Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dc99bb7afe5d45b7ba0fe5a2121edb74
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spelling	oai:doaj.org-article:dc99bb7afe5d45b7ba0fe5a2121edb742021-12-02T14:03:45ZA new congenital cleft palate New Zealand rabbit model for surgical research10.1038/s41598-021-83400-z2045-2322https://doaj.org/article/dc99bb7afe5d45b7ba0fe5a2121edb742021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83400-zhttps://doaj.org/toc/2045-2322Abstract Cleft palate repair is a challenging procedure for cleft surgeons to teach, and in research, it can be difficult to evaluate different techniques and develop new treatments. In this study, a congenital cleft palate New Zealand rabbit model has been described and could be beneficial in future studies concerning cleft palate repair. Pregnant New Zealand rabbits received 1.0 mg dexamethasone injection intramuscularly once a day from the 13th gestation day (GD13) to GD16. On GD31. Newborn rabbits were delivered by cesarean sections, fed with a standardized gastric tube feeding method, and divided into two groups. The rate of survival and the incidence of cleft palate was calculated. Weight, appearance, behavior, maxillary occlusal view, and regional anatomic and histological comparisons were recorded within 1 month after birth. Infants from the two groups with similar physiological conditions were selected for continuous maxillofacial and mandibular Micro-CT scan and three-dimensional reconstruction analysis. Ten pregnant rabbits gave birth to 48 live infants. The survival and cleft palate rates were 65.6% and 60.4% respectively. Both groups survived over 1 month with no difference in weight, appearance, and behavior. The cleft type was stable, and anatomical defects, histological characteristics, and nasal-maxillary abnormalities of the cleft were similar to those of humans. There was no statistically significant difference in maxillary and mandible development between the two groups within one month after birth. This congenital cleft palate model is considered to have more research possibilities with efficient cleft induction, reliable feeding methods, stable anatomical defects, and maxillofacial development similar to those seen in humans.Haoyue LiuLingling PuChialing TsauoXiaoming WangQian ZhengBing ShiChenghao LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Haoyue Liu Lingling Pu Chialing Tsauo Xiaoming Wang Qian Zheng Bing Shi Chenghao Li A new congenital cleft palate New Zealand rabbit model for surgical research
description	Abstract Cleft palate repair is a challenging procedure for cleft surgeons to teach, and in research, it can be difficult to evaluate different techniques and develop new treatments. In this study, a congenital cleft palate New Zealand rabbit model has been described and could be beneficial in future studies concerning cleft palate repair. Pregnant New Zealand rabbits received 1.0 mg dexamethasone injection intramuscularly once a day from the 13th gestation day (GD13) to GD16. On GD31. Newborn rabbits were delivered by cesarean sections, fed with a standardized gastric tube feeding method, and divided into two groups. The rate of survival and the incidence of cleft palate was calculated. Weight, appearance, behavior, maxillary occlusal view, and regional anatomic and histological comparisons were recorded within 1 month after birth. Infants from the two groups with similar physiological conditions were selected for continuous maxillofacial and mandibular Micro-CT scan and three-dimensional reconstruction analysis. Ten pregnant rabbits gave birth to 48 live infants. The survival and cleft palate rates were 65.6% and 60.4% respectively. Both groups survived over 1 month with no difference in weight, appearance, and behavior. The cleft type was stable, and anatomical defects, histological characteristics, and nasal-maxillary abnormalities of the cleft were similar to those of humans. There was no statistically significant difference in maxillary and mandible development between the two groups within one month after birth. This congenital cleft palate model is considered to have more research possibilities with efficient cleft induction, reliable feeding methods, stable anatomical defects, and maxillofacial development similar to those seen in humans.
format	article
author	Haoyue Liu Lingling Pu Chialing Tsauo Xiaoming Wang Qian Zheng Bing Shi Chenghao Li
author_facet	Haoyue Liu Lingling Pu Chialing Tsauo Xiaoming Wang Qian Zheng Bing Shi Chenghao Li
author_sort	Haoyue Liu
title	A new congenital cleft palate New Zealand rabbit model for surgical research
title_short	A new congenital cleft palate New Zealand rabbit model for surgical research
title_full	A new congenital cleft palate New Zealand rabbit model for surgical research
title_fullStr	A new congenital cleft palate New Zealand rabbit model for surgical research
title_full_unstemmed	A new congenital cleft palate New Zealand rabbit model for surgical research
title_sort	new congenital cleft palate new zealand rabbit model for surgical research
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dc99bb7afe5d45b7ba0fe5a2121edb74
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A new congenital cleft palate New Zealand rabbit model for surgical research

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