Antibodies to Cryptic Epitopes in Distant Homologues Underpin a Mechanism of Heterologous Immunity between <italic toggle="yes">Plasmodium vivax</italic> PvDBP and <italic toggle="yes">Plasmodium falciparum</italic> VAR2CSA

Antibodies to Cryptic Epitopes in Distant Homologues Underpin a Mechanism of Heterologous Immunity between <italic toggle="yes">Plasmodium vivax</italic> PvDBP and <italic toggle="yes">Plasmodium falciparum</italic> VAR2CSA

ABSTRACT Many pathogens evolve extensive genetic variation in virulence proteins as a strategy to evade host immunity. This poses a significant challenge for the host to develop broadly neutralizing antibodies. In Plasmodium falciparum, we show that a mechanism to circumvent this challenge is to eli...

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Autores principales: Catherine J. Mitran, Angie Mena, Sedami Gnidehou, Shanna Banman, Eliana Arango, Barbara A. S. Lima, Hazel Lugo, Aravindhan Ganesan, Ali Salanti, Anthony K. Mbonye, Francis Ntumngia, Khaled Barakat, John H. Adams, Flora S. Kano, Luzia H. Carvalho, Amanda E. Maestre, Michael F. Good, Stephanie K. Yanow
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2019
Materias:
Plasmodium
vivax
falciparum
VAR2CSA
PvDBP
heterologous immunity
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/dc9b125d83b4466294dd90ec1b790353
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