HIGH ALTITUDE AND VENOUS THROMBOSIS: FREQUENCY AND RISK FACTORS

Objective: To determine the effect of high altitude on frequency and risk factors of venous thrombosis in individuals ascending to high altitude Study Design: Cross-sectional analytical study. Place and Duration of Study: Armed Forces Bone Marrow Transplant Centre, Combined Military Hospital S...

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Autores principales:	Qamar Un-Nisa Choudry, Raheel Iftikhar, Manzur Qadir, Tariq Mehmood Satti, Ghassan Omair, Syed Kamran Mehmood
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2021
Materias:	embolism polycythemia thrombosis Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/dc9c6e406b234aa5b4e2dde0d149c76d
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spelling	oai:doaj.org-article:dc9c6e406b234aa5b4e2dde0d149c76d2021-12-02T17:10:37ZHIGH ALTITUDE AND VENOUS THROMBOSIS: FREQUENCY AND RISK FACTORS0030-96482411-884210.51253/pafmj.v71i1.3173https://doaj.org/article/dc9c6e406b234aa5b4e2dde0d149c76d2021-02-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/3173https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To determine the effect of high altitude on frequency and risk factors of venous thrombosis in individuals ascending to high altitude Study Design: Cross-sectional analytical study. Place and Duration of Study: Armed Forces Bone Marrow Transplant Centre, Combined Military Hospital Skardu, from Apr 2015 to Aug 2018. Methodology: High Altitude was taken as height equal to or more than 8000 feet. Polycythemia as hemoglobin >16.5 g/dl OR hematocrit >49%. Medical records of all patients evacuated from high altitude through Combined Military Hospital Skardu were analyzed retrospectively. A proforma was designed to include necessary variables. Results: We evaluated medical records of 539 individuals and found frequency of 86 (15.9%) for venous thromboembolism (VTE) at high altitude. Cerebral venous sinus thrombosis (CVST) was most common thrombotic complication seen in 39 patients (46%). Majority of thrombotic episodes occurred at >18000 feet (likelihood ratio (LR) 5.99, p-value 0.009). Majority of thrombotic episodes 34 (39%) occurred within first 45 days of ascent to high altitude. Thrombosis was linked to smoking 47 (55%) (likelihood ratio 21.3 and p-value <0.001) and use of melted snow as a source of drinking water 56 (65%) (likelihood ratio 57.6 and p-value <0.001). Conclusion: This study showed a very high frequency of thrombotic complications at high altitude. There is a need for a robust prospective study covering epidemiology, clinical information and diagnostics in order to develop appropriate standard operating procedures and guidelines for prevention of thrombosis at HAQamar Un-Nisa ChoudryRaheel IftikharManzur QadirTariq Mehmood SattiGhassan OmairSyed Kamran MehmoodArmy Medical College RawalpindiarticleembolismpolycythemiathrombosisMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 71, Iss 1, Pp 107-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	embolism polycythemia thrombosis Medicine R Medicine (General) R5-920
spellingShingle	embolism polycythemia thrombosis Medicine R Medicine (General) R5-920 Qamar Un-Nisa Choudry Raheel Iftikhar Manzur Qadir Tariq Mehmood Satti Ghassan Omair Syed Kamran Mehmood HIGH ALTITUDE AND VENOUS THROMBOSIS: FREQUENCY AND RISK FACTORS
description	Objective: To determine the effect of high altitude on frequency and risk factors of venous thrombosis in individuals ascending to high altitude Study Design: Cross-sectional analytical study. Place and Duration of Study: Armed Forces Bone Marrow Transplant Centre, Combined Military Hospital Skardu, from Apr 2015 to Aug 2018. Methodology: High Altitude was taken as height equal to or more than 8000 feet. Polycythemia as hemoglobin >16.5 g/dl OR hematocrit >49%. Medical records of all patients evacuated from high altitude through Combined Military Hospital Skardu were analyzed retrospectively. A proforma was designed to include necessary variables. Results: We evaluated medical records of 539 individuals and found frequency of 86 (15.9%) for venous thromboembolism (VTE) at high altitude. Cerebral venous sinus thrombosis (CVST) was most common thrombotic complication seen in 39 patients (46%). Majority of thrombotic episodes occurred at >18000 feet (likelihood ratio (LR) 5.99, p-value 0.009). Majority of thrombotic episodes 34 (39%) occurred within first 45 days of ascent to high altitude. Thrombosis was linked to smoking 47 (55%) (likelihood ratio 21.3 and p-value <0.001) and use of melted snow as a source of drinking water 56 (65%) (likelihood ratio 57.6 and p-value <0.001). Conclusion: This study showed a very high frequency of thrombotic complications at high altitude. There is a need for a robust prospective study covering epidemiology, clinical information and diagnostics in order to develop appropriate standard operating procedures and guidelines for prevention of thrombosis at HA
format	article
author	Qamar Un-Nisa Choudry Raheel Iftikhar Manzur Qadir Tariq Mehmood Satti Ghassan Omair Syed Kamran Mehmood
author_facet	Qamar Un-Nisa Choudry Raheel Iftikhar Manzur Qadir Tariq Mehmood Satti Ghassan Omair Syed Kamran Mehmood
author_sort	Qamar Un-Nisa Choudry
title	HIGH ALTITUDE AND VENOUS THROMBOSIS: FREQUENCY AND RISK FACTORS
title_short	HIGH ALTITUDE AND VENOUS THROMBOSIS: FREQUENCY AND RISK FACTORS
title_full	HIGH ALTITUDE AND VENOUS THROMBOSIS: FREQUENCY AND RISK FACTORS
title_fullStr	HIGH ALTITUDE AND VENOUS THROMBOSIS: FREQUENCY AND RISK FACTORS
title_full_unstemmed	HIGH ALTITUDE AND VENOUS THROMBOSIS: FREQUENCY AND RISK FACTORS
title_sort	high altitude and venous thrombosis: frequency and risk factors
publisher	Army Medical College Rawalpindi
publishDate	2021
url	https://doaj.org/article/dc9c6e406b234aa5b4e2dde0d149c76d
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HIGH ALTITUDE AND VENOUS THROMBOSIS: FREQUENCY AND RISK FACTORS

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