Mitochondria localization induced self-assembly of peptide amphiphiles for cellular dysfunction

Mitochondria localization induced self-assembly of peptide amphiphiles for cellular dysfunction

Spatiotemporal control of intracellular molecular self-assembly holds promise for therapeutic applications. Here the authors develop a peptide consisting of a phenylalanine dipeptide with a mitochondrial targeting moiety to form self-assembling fibrous nanostructures within mitochondria, leading to...

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Detalles Bibliográficos
Autores principales: M. T. Jeena, L. Palanikumar, Eun Min Go, Inhye Kim, Myoung Gyun Kang, Seonik Lee, Sooham Park, Huyeon Choi, Chaekyu Kim, Seon-Mi Jin, Sung Chul Bae, Hyun Woo Rhee, Eunji Lee, Sang Kyu Kwak, Ja-Hyoung Ryu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/dc9d282d64b94a43a9b085b9db93fb6f
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Sumario:Spatiotemporal control of intracellular molecular self-assembly holds promise for therapeutic applications. Here the authors develop a peptide consisting of a phenylalanine dipeptide with a mitochondrial targeting moiety to form self-assembling fibrous nanostructures within mitochondria, leading to apoptosis.

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