Mitochondria localization induced self-assembly of peptide amphiphiles for cellular dysfunction

Spatiotemporal control of intracellular molecular self-assembly holds promise for therapeutic applications. Here the authors develop a peptide consisting of a phenylalanine dipeptide with a mitochondrial targeting moiety to form self-assembling fibrous nanostructures within mitochondria, leading to...

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Main Authors:	M. T. Jeena, L. Palanikumar, Eun Min Go, Inhye Kim, Myoung Gyun Kang, Seonik Lee, Sooham Park, Huyeon Choi, Chaekyu Kim, Seon-Mi Jin, Sung Chul Bae, Hyun Woo Rhee, Eunji Lee, Sang Kyu Kwak, Ja-Hyoung Ryu
Format:	article
Language:	EN
Published:	Nature Portfolio 2017
Subjects:	Science Q
Online Access:	https://doaj.org/article/dc9d282d64b94a43a9b085b9db93fb6f
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spelling	oai:doaj.org-article:dc9d282d64b94a43a9b085b9db93fb6f2021-12-02T14:16:47ZMitochondria localization induced self-assembly of peptide amphiphiles for cellular dysfunction10.1038/s41467-017-00047-z2041-1723https://doaj.org/article/dc9d282d64b94a43a9b085b9db93fb6f2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00047-zhttps://doaj.org/toc/2041-1723Spatiotemporal control of intracellular molecular self-assembly holds promise for therapeutic applications. Here the authors develop a peptide consisting of a phenylalanine dipeptide with a mitochondrial targeting moiety to form self-assembling fibrous nanostructures within mitochondria, leading to apoptosis.M. T. JeenaL. PalanikumarEun Min GoInhye KimMyoung Gyun KangSeonik LeeSooham ParkHuyeon ChoiChaekyu KimSeon-Mi JinSung Chul BaeHyun Woo RheeEunji LeeSang Kyu KwakJa-Hyoung RyuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q M. T. Jeena L. Palanikumar Eun Min Go Inhye Kim Myoung Gyun Kang Seonik Lee Sooham Park Huyeon Choi Chaekyu Kim Seon-Mi Jin Sung Chul Bae Hyun Woo Rhee Eunji Lee Sang Kyu Kwak Ja-Hyoung Ryu Mitochondria localization induced self-assembly of peptide amphiphiles for cellular dysfunction
description	Spatiotemporal control of intracellular molecular self-assembly holds promise for therapeutic applications. Here the authors develop a peptide consisting of a phenylalanine dipeptide with a mitochondrial targeting moiety to form self-assembling fibrous nanostructures within mitochondria, leading to apoptosis.
format	article
author	M. T. Jeena L. Palanikumar Eun Min Go Inhye Kim Myoung Gyun Kang Seonik Lee Sooham Park Huyeon Choi Chaekyu Kim Seon-Mi Jin Sung Chul Bae Hyun Woo Rhee Eunji Lee Sang Kyu Kwak Ja-Hyoung Ryu
author_facet	M. T. Jeena L. Palanikumar Eun Min Go Inhye Kim Myoung Gyun Kang Seonik Lee Sooham Park Huyeon Choi Chaekyu Kim Seon-Mi Jin Sung Chul Bae Hyun Woo Rhee Eunji Lee Sang Kyu Kwak Ja-Hyoung Ryu
author_sort	M. T. Jeena
title	Mitochondria localization induced self-assembly of peptide amphiphiles for cellular dysfunction
title_short	Mitochondria localization induced self-assembly of peptide amphiphiles for cellular dysfunction
title_full	Mitochondria localization induced self-assembly of peptide amphiphiles for cellular dysfunction
title_fullStr	Mitochondria localization induced self-assembly of peptide amphiphiles for cellular dysfunction
title_full_unstemmed	Mitochondria localization induced self-assembly of peptide amphiphiles for cellular dysfunction
title_sort	mitochondria localization induced self-assembly of peptide amphiphiles for cellular dysfunction
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/dc9d282d64b94a43a9b085b9db93fb6f
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Mitochondria localization induced self-assembly of peptide amphiphiles for cellular dysfunction

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