GORAB scaffolds COPI at the trans-Golgi for efficient enzyme recycling and correct protein glycosylation
COPI is recruited to the membrane by binding to Arf GTPases. Here the authors find that GORAB, a trans-Golgi protein, promotes COPI recruitment by forming membrane domains that also contain the COPI-interacting protein Scyl1, which is required for efficient glycosylation of cargo proteins.
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Nature Portfolio
2019
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oai:doaj.org-article:dc9f0e13809c4552a2294779156678652021-12-02T15:35:30ZGORAB scaffolds COPI at the trans-Golgi for efficient enzyme recycling and correct protein glycosylation10.1038/s41467-018-08044-62041-1723https://doaj.org/article/dc9f0e13809c4552a2294779156678652019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08044-6https://doaj.org/toc/2041-1723COPI is recruited to the membrane by binding to Arf GTPases. Here the authors find that GORAB, a trans-Golgi protein, promotes COPI recruitment by forming membrane domains that also contain the COPI-interacting protein Scyl1, which is required for efficient glycosylation of cargo proteins.Tomasz M. WitkosWing Lee ChanMerja JoensuuManuel RhielEd PallisterJane Thomas-OatesA. Paul MouldAlex A. MironovChristophe BiotYann GuerardelWilly MorelleDaniel UngarFelix T. WielandEija JokitaloMay TassabehjiUwe KornakMartin LoweNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Tomasz M. Witkos Wing Lee Chan Merja Joensuu Manuel Rhiel Ed Pallister Jane Thomas-Oates A. Paul Mould Alex A. Mironov Christophe Biot Yann Guerardel Willy Morelle Daniel Ungar Felix T. Wieland Eija Jokitalo May Tassabehji Uwe Kornak Martin Lowe GORAB scaffolds COPI at the trans-Golgi for efficient enzyme recycling and correct protein glycosylation |
| description |
COPI is recruited to the membrane by binding to Arf GTPases. Here the authors find that GORAB, a trans-Golgi protein, promotes COPI recruitment by forming membrane domains that also contain the COPI-interacting protein Scyl1, which is required for efficient glycosylation of cargo proteins. |
| format |
article |
| author |
Tomasz M. Witkos Wing Lee Chan Merja Joensuu Manuel Rhiel Ed Pallister Jane Thomas-Oates A. Paul Mould Alex A. Mironov Christophe Biot Yann Guerardel Willy Morelle Daniel Ungar Felix T. Wieland Eija Jokitalo May Tassabehji Uwe Kornak Martin Lowe |
| author_facet |
Tomasz M. Witkos Wing Lee Chan Merja Joensuu Manuel Rhiel Ed Pallister Jane Thomas-Oates A. Paul Mould Alex A. Mironov Christophe Biot Yann Guerardel Willy Morelle Daniel Ungar Felix T. Wieland Eija Jokitalo May Tassabehji Uwe Kornak Martin Lowe |
| author_sort |
Tomasz M. Witkos |
| title |
GORAB scaffolds COPI at the trans-Golgi for efficient enzyme recycling and correct protein glycosylation |
| title_short |
GORAB scaffolds COPI at the trans-Golgi for efficient enzyme recycling and correct protein glycosylation |
| title_full |
GORAB scaffolds COPI at the trans-Golgi for efficient enzyme recycling and correct protein glycosylation |
| title_fullStr |
GORAB scaffolds COPI at the trans-Golgi for efficient enzyme recycling and correct protein glycosylation |
| title_full_unstemmed |
GORAB scaffolds COPI at the trans-Golgi for efficient enzyme recycling and correct protein glycosylation |
| title_sort |
gorab scaffolds copi at the trans-golgi for efficient enzyme recycling and correct protein glycosylation |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/dc9f0e13809c4552a229477915667865 |
| work_keys_str_mv |
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| _version_ |
1718386565268373504 |