Construction of developmental lineage relationships in the mouse mammary gland by single-cell RNA profiling

The mammary epithelium comprises two cell lineages but the heterogeneity amongst these during development is unclear. Here, the authors report single-cell RNA sequencing of the mouse mammary epithelium at four developmental stages, revealing diversity in both compartments and a transcriptional shift...

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Autores principales: Bhupinder Pal, Yunshun Chen, François Vaillant, Paul Jamieson, Lavinia Gordon, Anne C. Rios, Stephen Wilcox, Naiyang Fu, Kevin He Liu, Felicity C. Jackling, Melissa J. Davis, Geoffrey J. Lindeman, Gordon K. Smyth, Jane E. Visvader
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/dca0603f7480455abce0a865cd2cb6d0
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Sumario:The mammary epithelium comprises two cell lineages but the heterogeneity amongst these during development is unclear. Here, the authors report single-cell RNA sequencing of the mouse mammary epithelium at four developmental stages, revealing diversity in both compartments and a transcriptional shift with puberty onset.