Changes in fatty acid levels (saturated, monounsaturated and polyunsaturated) during pregnancy

Abstract Background During pregnancy a high amount of fatty acids (FA) is necessary to meet foetus demands, which vary during gestation. The present study describes the changes in maternal fatty acid concentrations during pregnancy in a sample of pregnant women. Methods This is a longitudinal study...

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Autores principales:	Estefania Aparicio, Carla Martín-Grau, Carmen Hernández-Martinez, Nuria Voltas, Josefa Canals, Victoria Arija
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Pregnancy Fatty acid status DHA EPA Omega-3 Omega-6 Gynecology and obstetrics RG1-991
Acceso en línea:	https://doaj.org/article/dca104ca420140e5851f6008c99112a6
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spelling	oai:doaj.org-article:dca104ca420140e5851f6008c99112a62021-11-21T12:32:46ZChanges in fatty acid levels (saturated, monounsaturated and polyunsaturated) during pregnancy10.1186/s12884-021-04251-01471-2393https://doaj.org/article/dca104ca420140e5851f6008c99112a62021-11-01T00:00:00Zhttps://doi.org/10.1186/s12884-021-04251-0https://doaj.org/toc/1471-2393Abstract Background During pregnancy a high amount of fatty acids (FA) is necessary to meet foetus demands, which vary during gestation. The present study describes the changes in maternal fatty acid concentrations during pregnancy in a sample of pregnant women. Methods This is a longitudinal study of 479 pregnant women who were monitored from the first trimester to third trimester of pregnancy. Data on maternal characteristics were recorded and a serum sample was collected in each trimester. The fatty acid profile (saturated (SFA: total, lauric acid, myristic acid, palmitic acid, stearic acid), monounsaturated (MUFA: total, palmitoleic acid, oleic acid) and polyunsaturated fatty acids (PUFA: total omega-6 (n-6), linoleic acid, dihomo-γ-linolenic acid, arachidonic acid (AA), total omega-3 (n-3), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA)) was analysed with a gas chromatography-mass spectrometry combination. Results From the first trimester to third trimester of pregnancy, a significant increase in total SFA, total MUFA and total n-6 PUFA was found. (p < 0.001). Nevertheless, the serum concentration of arachidonic acid (AA), eicosapentaenoic acid (EPA) and total n-3 PUFA decreased during gestation (p < 0.001). A statistically non-significant result was observed for the docosahexaenoic acid (DHA) serum concentration between the first and third trimesters of pregnancy. Significant correlations were observed between each total fatty acid concentrations of the first and third trimesters. Conclusion The circulating serum concentration of SFA, MUFA and n-6 PUFA increases during pregnancy, whereas essential fatty acids such as AA and EPA decrease, and DHA remains unchanged. Further research is necessary to understand the role played by FA throughout gestation.Estefania AparicioCarla Martín-GrauCarmen Hernández-MartinezNuria VoltasJosefa CanalsVictoria ArijaBMCarticlePregnancyFatty acid statusDHAEPAOmega-3Omega-6Gynecology and obstetricsRG1-991ENBMC Pregnancy and Childbirth, Vol 21, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pregnancy Fatty acid status DHA EPA Omega-3 Omega-6 Gynecology and obstetrics RG1-991
spellingShingle	Pregnancy Fatty acid status DHA EPA Omega-3 Omega-6 Gynecology and obstetrics RG1-991 Estefania Aparicio Carla Martín-Grau Carmen Hernández-Martinez Nuria Voltas Josefa Canals Victoria Arija Changes in fatty acid levels (saturated, monounsaturated and polyunsaturated) during pregnancy
description	Abstract Background During pregnancy a high amount of fatty acids (FA) is necessary to meet foetus demands, which vary during gestation. The present study describes the changes in maternal fatty acid concentrations during pregnancy in a sample of pregnant women. Methods This is a longitudinal study of 479 pregnant women who were monitored from the first trimester to third trimester of pregnancy. Data on maternal characteristics were recorded and a serum sample was collected in each trimester. The fatty acid profile (saturated (SFA: total, lauric acid, myristic acid, palmitic acid, stearic acid), monounsaturated (MUFA: total, palmitoleic acid, oleic acid) and polyunsaturated fatty acids (PUFA: total omega-6 (n-6), linoleic acid, dihomo-γ-linolenic acid, arachidonic acid (AA), total omega-3 (n-3), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA)) was analysed with a gas chromatography-mass spectrometry combination. Results From the first trimester to third trimester of pregnancy, a significant increase in total SFA, total MUFA and total n-6 PUFA was found. (p < 0.001). Nevertheless, the serum concentration of arachidonic acid (AA), eicosapentaenoic acid (EPA) and total n-3 PUFA decreased during gestation (p < 0.001). A statistically non-significant result was observed for the docosahexaenoic acid (DHA) serum concentration between the first and third trimesters of pregnancy. Significant correlations were observed between each total fatty acid concentrations of the first and third trimesters. Conclusion The circulating serum concentration of SFA, MUFA and n-6 PUFA increases during pregnancy, whereas essential fatty acids such as AA and EPA decrease, and DHA remains unchanged. Further research is necessary to understand the role played by FA throughout gestation.
format	article
author	Estefania Aparicio Carla Martín-Grau Carmen Hernández-Martinez Nuria Voltas Josefa Canals Victoria Arija
author_facet	Estefania Aparicio Carla Martín-Grau Carmen Hernández-Martinez Nuria Voltas Josefa Canals Victoria Arija
author_sort	Estefania Aparicio
title	Changes in fatty acid levels (saturated, monounsaturated and polyunsaturated) during pregnancy
title_short	Changes in fatty acid levels (saturated, monounsaturated and polyunsaturated) during pregnancy
title_full	Changes in fatty acid levels (saturated, monounsaturated and polyunsaturated) during pregnancy
title_fullStr	Changes in fatty acid levels (saturated, monounsaturated and polyunsaturated) during pregnancy
title_full_unstemmed	Changes in fatty acid levels (saturated, monounsaturated and polyunsaturated) during pregnancy
title_sort	changes in fatty acid levels (saturated, monounsaturated and polyunsaturated) during pregnancy
publisher	BMC
publishDate	2021
url	https://doaj.org/article/dca104ca420140e5851f6008c99112a6
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Changes in fatty acid levels (saturated, monounsaturated and polyunsaturated) during pregnancy

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