Tropinone synthesis via an atypical polyketide synthase and P450-mediated cyclization

Tropinone is an intermediate in the biosynthesis of tropane alkaloids. Here, the authors discovered the enzymes AbPYKS and AbCYP82M3, a non-canonical polyketide synthase and a cytochrome P450, that work sequentially to form tropinone from N-methyl-Δ1-pyrrolinium cation.

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Autores principales:	Matthew A. Bedewitz, A. Daniel Jones, John C. D’Auria, Cornelius S. Barry
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dca28ed7d56547e7b40945ddfead78c4
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spelling	oai:doaj.org-article:dca28ed7d56547e7b40945ddfead78c42021-12-02T16:50:05ZTropinone synthesis via an atypical polyketide synthase and P450-mediated cyclization10.1038/s41467-018-07671-32041-1723https://doaj.org/article/dca28ed7d56547e7b40945ddfead78c42018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07671-3https://doaj.org/toc/2041-1723Tropinone is an intermediate in the biosynthesis of tropane alkaloids. Here, the authors discovered the enzymes AbPYKS and AbCYP82M3, a non-canonical polyketide synthase and a cytochrome P450, that work sequentially to form tropinone from N-methyl-Δ1-pyrrolinium cation.Matthew A. BedewitzA. Daniel JonesJohn C. D’AuriaCornelius S. BarryNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matthew A. Bedewitz A. Daniel Jones John C. D’Auria Cornelius S. Barry Tropinone synthesis via an atypical polyketide synthase and P450-mediated cyclization
description	Tropinone is an intermediate in the biosynthesis of tropane alkaloids. Here, the authors discovered the enzymes AbPYKS and AbCYP82M3, a non-canonical polyketide synthase and a cytochrome P450, that work sequentially to form tropinone from N-methyl-Δ1-pyrrolinium cation.
format	article
author	Matthew A. Bedewitz A. Daniel Jones John C. D’Auria Cornelius S. Barry
author_facet	Matthew A. Bedewitz A. Daniel Jones John C. D’Auria Cornelius S. Barry
author_sort	Matthew A. Bedewitz
title	Tropinone synthesis via an atypical polyketide synthase and P450-mediated cyclization
title_short	Tropinone synthesis via an atypical polyketide synthase and P450-mediated cyclization
title_full	Tropinone synthesis via an atypical polyketide synthase and P450-mediated cyclization
title_fullStr	Tropinone synthesis via an atypical polyketide synthase and P450-mediated cyclization
title_full_unstemmed	Tropinone synthesis via an atypical polyketide synthase and P450-mediated cyclization
title_sort	tropinone synthesis via an atypical polyketide synthase and p450-mediated cyclization
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/dca28ed7d56547e7b40945ddfead78c4
work_keys_str_mv	AT matthewabedewitz tropinonesynthesisviaanatypicalpolyketidesynthaseandp450mediatedcyclization AT adanieljones tropinonesynthesisviaanatypicalpolyketidesynthaseandp450mediatedcyclization AT johncdauria tropinonesynthesisviaanatypicalpolyketidesynthaseandp450mediatedcyclization AT corneliussbarry tropinonesynthesisviaanatypicalpolyketidesynthaseandp450mediatedcyclization
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Tropinone synthesis via an atypical polyketide synthase and P450-mediated cyclization

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