The Importance of Being a ‘Lark’ in Post-Menopausal Women with Obesity: A Ploy to Prevent Type 2 Diabetes Mellitus?

Chronotype is defined as the behavioral manifestation of circadian rhythms related to the external light–dark cycle. Evening chronotype has been associated with an increased risk of developing cardiometabolic diseases in obesity. Menopause is a lifestage associated with an increased risk of developi...

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Autores principales:	Luigi Barrea, Claudia Vetrani, Barbara Altieri, Ludovica Verde, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	chronotype circadian rhythms menopause obesity type 2 diabetes cardiovascular diseases Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/dca754716d2b4a9dab4ba0289244b9b9
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spelling	oai:doaj.org-article:dca754716d2b4a9dab4ba0289244b9b92021-11-25T18:33:51ZThe Importance of Being a ‘Lark’ in Post-Menopausal Women with Obesity: A Ploy to Prevent Type 2 Diabetes Mellitus?10.3390/nu131137622072-6643https://doaj.org/article/dca754716d2b4a9dab4ba0289244b9b92021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3762https://doaj.org/toc/2072-6643Chronotype is defined as the behavioral manifestation of circadian rhythms related to the external light–dark cycle. Evening chronotype has been associated with an increased risk of developing cardiometabolic diseases in obesity. Menopause is a lifestage associated with an increased risk of developing cardiometabolic diseases and a change in circadian rhythmicity compared to pre-menopause. However, the prevalence of chronotype categories in menopause and their role in determining menopause-related cardiometabolic risk, mostly in obesity, have not been investigated. Thus, we aimed to investigate the prevalence of chronotype categories in post-menopausal women with obesity and their role in menopause-related cardiometabolic risk. In this cross-sectional study we enrolled 49 pre-menopausal and 74 post-menopausal women with obesity. Anthropometric parameters, lifestyle habits, adherence to the Mediterranean Diet (MD), sleep quality, chronotype and the presence of type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVD) were studied. No significance differences were detected in terms of lifestyle and adherence to the MD between pre- and post-menopausal women. Chronotype was classified as morning in 66 (53.6%), evening in 20 (16.3%) and intermediate in 37 (30.1%) women. In addition, pre-menopausal women with obesity showed a significantly higher chance to have an intermediate chronotype (OR = 2.21, 95% CI 1.28–3.83; <i>p</i> = 0.004), whereas post-menopausal women with obesity showed a trend to have a higher morning chronotype (OR = 1.42, 95% CI 0.98–2.06; <i>p</i> = 0.051), although this did not reach statistical significance. No significant differences were detected in terms of prevalence of evening chronotype between the two groups. However, the evening chronotype had a significantly higher risk to have T2DM compared to the morning (OR = 17.29, 95% CI 2.40–124.27; <i>p</i> = 0.005) and intermediate chronotypes (OR = 30.86, 95% CI 2.05–464.32; <i>p</i> = 0.013) in both pre- and post-menopausal women with obesity. In conclusion, the intermediate chronotype was significantly more prevalent in pre-menopausal women with obesity compared to post-menopausal women. Evening chronotype was associated to T2DM in both pre- and post-menopause. These results support the importance of including the assessment of chronotype in the management of women with obesity in post-menopause.Luigi BarreaClaudia VetraniBarbara AltieriLudovica VerdeSilvia SavastanoAnnamaria ColaoGiovanna MuscogiuriMDPI AGarticlechronotypecircadian rhythmsmenopauseobesitytype 2 diabetescardiovascular diseasesNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3762, p 3762 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chronotype circadian rhythms menopause obesity type 2 diabetes cardiovascular diseases Nutrition. Foods and food supply TX341-641
spellingShingle	chronotype circadian rhythms menopause obesity type 2 diabetes cardiovascular diseases Nutrition. Foods and food supply TX341-641 Luigi Barrea Claudia Vetrani Barbara Altieri Ludovica Verde Silvia Savastano Annamaria Colao Giovanna Muscogiuri The Importance of Being a ‘Lark’ in Post-Menopausal Women with Obesity: A Ploy to Prevent Type 2 Diabetes Mellitus?
description	Chronotype is defined as the behavioral manifestation of circadian rhythms related to the external light–dark cycle. Evening chronotype has been associated with an increased risk of developing cardiometabolic diseases in obesity. Menopause is a lifestage associated with an increased risk of developing cardiometabolic diseases and a change in circadian rhythmicity compared to pre-menopause. However, the prevalence of chronotype categories in menopause and their role in determining menopause-related cardiometabolic risk, mostly in obesity, have not been investigated. Thus, we aimed to investigate the prevalence of chronotype categories in post-menopausal women with obesity and their role in menopause-related cardiometabolic risk. In this cross-sectional study we enrolled 49 pre-menopausal and 74 post-menopausal women with obesity. Anthropometric parameters, lifestyle habits, adherence to the Mediterranean Diet (MD), sleep quality, chronotype and the presence of type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVD) were studied. No significance differences were detected in terms of lifestyle and adherence to the MD between pre- and post-menopausal women. Chronotype was classified as morning in 66 (53.6%), evening in 20 (16.3%) and intermediate in 37 (30.1%) women. In addition, pre-menopausal women with obesity showed a significantly higher chance to have an intermediate chronotype (OR = 2.21, 95% CI 1.28–3.83; <i>p</i> = 0.004), whereas post-menopausal women with obesity showed a trend to have a higher morning chronotype (OR = 1.42, 95% CI 0.98–2.06; <i>p</i> = 0.051), although this did not reach statistical significance. No significant differences were detected in terms of prevalence of evening chronotype between the two groups. However, the evening chronotype had a significantly higher risk to have T2DM compared to the morning (OR = 17.29, 95% CI 2.40–124.27; <i>p</i> = 0.005) and intermediate chronotypes (OR = 30.86, 95% CI 2.05–464.32; <i>p</i> = 0.013) in both pre- and post-menopausal women with obesity. In conclusion, the intermediate chronotype was significantly more prevalent in pre-menopausal women with obesity compared to post-menopausal women. Evening chronotype was associated to T2DM in both pre- and post-menopause. These results support the importance of including the assessment of chronotype in the management of women with obesity in post-menopause.
format	article
author	Luigi Barrea Claudia Vetrani Barbara Altieri Ludovica Verde Silvia Savastano Annamaria Colao Giovanna Muscogiuri
author_facet	Luigi Barrea Claudia Vetrani Barbara Altieri Ludovica Verde Silvia Savastano Annamaria Colao Giovanna Muscogiuri
author_sort	Luigi Barrea
title	The Importance of Being a ‘Lark’ in Post-Menopausal Women with Obesity: A Ploy to Prevent Type 2 Diabetes Mellitus?
title_short	The Importance of Being a ‘Lark’ in Post-Menopausal Women with Obesity: A Ploy to Prevent Type 2 Diabetes Mellitus?
title_full	The Importance of Being a ‘Lark’ in Post-Menopausal Women with Obesity: A Ploy to Prevent Type 2 Diabetes Mellitus?
title_fullStr	The Importance of Being a ‘Lark’ in Post-Menopausal Women with Obesity: A Ploy to Prevent Type 2 Diabetes Mellitus?
title_full_unstemmed	The Importance of Being a ‘Lark’ in Post-Menopausal Women with Obesity: A Ploy to Prevent Type 2 Diabetes Mellitus?
title_sort	importance of being a ‘lark’ in post-menopausal women with obesity: a ploy to prevent type 2 diabetes mellitus?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/dca754716d2b4a9dab4ba0289244b9b9
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The Importance of Being a ‘Lark’ in Post-Menopausal Women with Obesity: A Ploy to Prevent Type 2 Diabetes Mellitus?

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