Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases
Histone post-translational modifications are known key regulators of gene expression. Here, the authors characterize histone crotonylation at histone H3 lysine 18 in intestinal epithelia and find that it is a highly dynamic cell cycle regulated mark under the regulation of the HDAC deacetylases.
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oai:doaj.org-article:dcb0d5694cd141d7940f735b72dfe7cb2021-12-02T14:40:55ZMicrobiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases10.1038/s41467-017-02651-52041-1723https://doaj.org/article/dcb0d5694cd141d7940f735b72dfe7cb2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02651-5https://doaj.org/toc/2041-1723Histone post-translational modifications are known key regulators of gene expression. Here, the authors characterize histone crotonylation at histone H3 lysine 18 in intestinal epithelia and find that it is a highly dynamic cell cycle regulated mark under the regulation of the HDAC deacetylases.Rachel FellowsJérémy DenizotClaudia StellatoAlessandro CuomoPayal JainElena StoyanovaSzabina BalázsiZoltán HajnádyAnke LiebertJuri KazakevychHector BlackburnRenan Oliveira CorrêaJosé Luís FachiFabio Takeo SatoWillian R. RibeiroCaroline Marcantonio FerreiraHélène PeréeMariangela SpagnuoloRaphaël MattiuzCsaba MatolcsiJoana GuedesJonathan ClarkMarc VeldhoenTiziana BonaldiMarco Aurélio Ramirez VinoloPatrick Varga-WeiszNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018) |
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Science Q Rachel Fellows Jérémy Denizot Claudia Stellato Alessandro Cuomo Payal Jain Elena Stoyanova Szabina Balázsi Zoltán Hajnády Anke Liebert Juri Kazakevych Hector Blackburn Renan Oliveira Corrêa José Luís Fachi Fabio Takeo Sato Willian R. Ribeiro Caroline Marcantonio Ferreira Hélène Perée Mariangela Spagnuolo Raphaël Mattiuz Csaba Matolcsi Joana Guedes Jonathan Clark Marc Veldhoen Tiziana Bonaldi Marco Aurélio Ramirez Vinolo Patrick Varga-Weisz Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases |
description |
Histone post-translational modifications are known key regulators of gene expression. Here, the authors characterize histone crotonylation at histone H3 lysine 18 in intestinal epithelia and find that it is a highly dynamic cell cycle regulated mark under the regulation of the HDAC deacetylases. |
format |
article |
author |
Rachel Fellows Jérémy Denizot Claudia Stellato Alessandro Cuomo Payal Jain Elena Stoyanova Szabina Balázsi Zoltán Hajnády Anke Liebert Juri Kazakevych Hector Blackburn Renan Oliveira Corrêa José Luís Fachi Fabio Takeo Sato Willian R. Ribeiro Caroline Marcantonio Ferreira Hélène Perée Mariangela Spagnuolo Raphaël Mattiuz Csaba Matolcsi Joana Guedes Jonathan Clark Marc Veldhoen Tiziana Bonaldi Marco Aurélio Ramirez Vinolo Patrick Varga-Weisz |
author_facet |
Rachel Fellows Jérémy Denizot Claudia Stellato Alessandro Cuomo Payal Jain Elena Stoyanova Szabina Balázsi Zoltán Hajnády Anke Liebert Juri Kazakevych Hector Blackburn Renan Oliveira Corrêa José Luís Fachi Fabio Takeo Sato Willian R. Ribeiro Caroline Marcantonio Ferreira Hélène Perée Mariangela Spagnuolo Raphaël Mattiuz Csaba Matolcsi Joana Guedes Jonathan Clark Marc Veldhoen Tiziana Bonaldi Marco Aurélio Ramirez Vinolo Patrick Varga-Weisz |
author_sort |
Rachel Fellows |
title |
Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases |
title_short |
Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases |
title_full |
Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases |
title_fullStr |
Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases |
title_full_unstemmed |
Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases |
title_sort |
microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases |
publisher |
Nature Portfolio |
publishDate |
2018 |
url |
https://doaj.org/article/dcb0d5694cd141d7940f735b72dfe7cb |
work_keys_str_mv |
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