Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases

Histone post-translational modifications are known key regulators of gene expression. Here, the authors characterize histone crotonylation at histone H3 lysine 18 in intestinal epithelia and find that it is a highly dynamic cell cycle regulated mark under the regulation of the HDAC deacetylases.

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Autores principales: Rachel Fellows, Jérémy Denizot, Claudia Stellato, Alessandro Cuomo, Payal Jain, Elena Stoyanova, Szabina Balázsi, Zoltán Hajnády, Anke Liebert, Juri Kazakevych, Hector Blackburn, Renan Oliveira Corrêa, José Luís Fachi, Fabio Takeo Sato, Willian R. Ribeiro, Caroline Marcantonio Ferreira, Hélène Perée, Mariangela Spagnuolo, Raphaël Mattiuz, Csaba Matolcsi, Joana Guedes, Jonathan Clark, Marc Veldhoen, Tiziana Bonaldi, Marco Aurélio Ramirez Vinolo, Patrick Varga-Weisz
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Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/dcb0d5694cd141d7940f735b72dfe7cb
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spelling oai:doaj.org-article:dcb0d5694cd141d7940f735b72dfe7cb2021-12-02T14:40:55ZMicrobiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases10.1038/s41467-017-02651-52041-1723https://doaj.org/article/dcb0d5694cd141d7940f735b72dfe7cb2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02651-5https://doaj.org/toc/2041-1723Histone post-translational modifications are known key regulators of gene expression. Here, the authors characterize histone crotonylation at histone H3 lysine 18 in intestinal epithelia and find that it is a highly dynamic cell cycle regulated mark under the regulation of the HDAC deacetylases.Rachel FellowsJérémy DenizotClaudia StellatoAlessandro CuomoPayal JainElena StoyanovaSzabina BalázsiZoltán HajnádyAnke LiebertJuri KazakevychHector BlackburnRenan Oliveira CorrêaJosé Luís FachiFabio Takeo SatoWillian R. RibeiroCaroline Marcantonio FerreiraHélène PeréeMariangela SpagnuoloRaphaël MattiuzCsaba MatolcsiJoana GuedesJonathan ClarkMarc VeldhoenTiziana BonaldiMarco Aurélio Ramirez VinoloPatrick Varga-WeiszNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Rachel Fellows
Jérémy Denizot
Claudia Stellato
Alessandro Cuomo
Payal Jain
Elena Stoyanova
Szabina Balázsi
Zoltán Hajnády
Anke Liebert
Juri Kazakevych
Hector Blackburn
Renan Oliveira Corrêa
José Luís Fachi
Fabio Takeo Sato
Willian R. Ribeiro
Caroline Marcantonio Ferreira
Hélène Perée
Mariangela Spagnuolo
Raphaël Mattiuz
Csaba Matolcsi
Joana Guedes
Jonathan Clark
Marc Veldhoen
Tiziana Bonaldi
Marco Aurélio Ramirez Vinolo
Patrick Varga-Weisz
Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases
description Histone post-translational modifications are known key regulators of gene expression. Here, the authors characterize histone crotonylation at histone H3 lysine 18 in intestinal epithelia and find that it is a highly dynamic cell cycle regulated mark under the regulation of the HDAC deacetylases.
format article
author Rachel Fellows
Jérémy Denizot
Claudia Stellato
Alessandro Cuomo
Payal Jain
Elena Stoyanova
Szabina Balázsi
Zoltán Hajnády
Anke Liebert
Juri Kazakevych
Hector Blackburn
Renan Oliveira Corrêa
José Luís Fachi
Fabio Takeo Sato
Willian R. Ribeiro
Caroline Marcantonio Ferreira
Hélène Perée
Mariangela Spagnuolo
Raphaël Mattiuz
Csaba Matolcsi
Joana Guedes
Jonathan Clark
Marc Veldhoen
Tiziana Bonaldi
Marco Aurélio Ramirez Vinolo
Patrick Varga-Weisz
author_facet Rachel Fellows
Jérémy Denizot
Claudia Stellato
Alessandro Cuomo
Payal Jain
Elena Stoyanova
Szabina Balázsi
Zoltán Hajnády
Anke Liebert
Juri Kazakevych
Hector Blackburn
Renan Oliveira Corrêa
José Luís Fachi
Fabio Takeo Sato
Willian R. Ribeiro
Caroline Marcantonio Ferreira
Hélène Perée
Mariangela Spagnuolo
Raphaël Mattiuz
Csaba Matolcsi
Joana Guedes
Jonathan Clark
Marc Veldhoen
Tiziana Bonaldi
Marco Aurélio Ramirez Vinolo
Patrick Varga-Weisz
author_sort Rachel Fellows
title Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases
title_short Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases
title_full Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases
title_fullStr Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases
title_full_unstemmed Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases
title_sort microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/dcb0d5694cd141d7940f735b72dfe7cb
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