Sleep mediates the association between homocysteine and oxidative status in mild cognitive impairment

Abstract Tremendous progress has been made over the last few years in understanding how sleep and amyloid-β (Aβ) cooperate to speed up the progression of Alzheimer’s disease (AD). However, it remains unknown whether sleep deficits also interact with other risk factors that exacerbate the pathologica...

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Autores principales:	Mayely P. Sanchez-Espinosa, Mercedes Atienza, Jose L. Cantero
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dcbaa1f6c1b64db98537df177efde6b1
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spelling	oai:doaj.org-article:dcbaa1f6c1b64db98537df177efde6b12021-12-02T12:32:30ZSleep mediates the association between homocysteine and oxidative status in mild cognitive impairment10.1038/s41598-017-08292-42045-2322https://doaj.org/article/dcbaa1f6c1b64db98537df177efde6b12017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08292-4https://doaj.org/toc/2045-2322Abstract Tremendous progress has been made over the last few years in understanding how sleep and amyloid-β (Aβ) cooperate to speed up the progression of Alzheimer’s disease (AD). However, it remains unknown whether sleep deficits also interact with other risk factors that exacerbate the pathological cascade of AD. Based on evidence showing that higher levels of homocysteine (HCY) and sleep loss increase oxidative damage, we here investigate whether the relationship between HCY and total antioxidant capacity (TAC) is mediated by changes in objective sleep in healthy older (HO, N = 21) and mild cognitive impairment (MCI, N = 21) subjects. Results revealed that reduced TAC levels in MCI was significantly correlated with increased HCY, shorter sleep duration, lower sleep efficiency, and reduced volume of temporal regions. However, only the HCY-TAC association showed diagnostic value, and this relationship was mediated by poorer sleep quality in MCI patients. We further showed that HCY-related cerebral volume loss in MCI depended on the serial relationship between poorer sleep quality and lower TAC levels. These findings provide novel insights into how impaired sleep may contribute to maintain the relationship between HCY and oxidative stress in prodromal AD, and offer empirical foundations to design therapeutic interventions aimed to weaken this link.Mayely P. Sanchez-EspinosaMercedes AtienzaJose L. CanteroNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mayely P. Sanchez-Espinosa Mercedes Atienza Jose L. Cantero Sleep mediates the association between homocysteine and oxidative status in mild cognitive impairment
description	Abstract Tremendous progress has been made over the last few years in understanding how sleep and amyloid-β (Aβ) cooperate to speed up the progression of Alzheimer’s disease (AD). However, it remains unknown whether sleep deficits also interact with other risk factors that exacerbate the pathological cascade of AD. Based on evidence showing that higher levels of homocysteine (HCY) and sleep loss increase oxidative damage, we here investigate whether the relationship between HCY and total antioxidant capacity (TAC) is mediated by changes in objective sleep in healthy older (HO, N = 21) and mild cognitive impairment (MCI, N = 21) subjects. Results revealed that reduced TAC levels in MCI was significantly correlated with increased HCY, shorter sleep duration, lower sleep efficiency, and reduced volume of temporal regions. However, only the HCY-TAC association showed diagnostic value, and this relationship was mediated by poorer sleep quality in MCI patients. We further showed that HCY-related cerebral volume loss in MCI depended on the serial relationship between poorer sleep quality and lower TAC levels. These findings provide novel insights into how impaired sleep may contribute to maintain the relationship between HCY and oxidative stress in prodromal AD, and offer empirical foundations to design therapeutic interventions aimed to weaken this link.
format	article
author	Mayely P. Sanchez-Espinosa Mercedes Atienza Jose L. Cantero
author_facet	Mayely P. Sanchez-Espinosa Mercedes Atienza Jose L. Cantero
author_sort	Mayely P. Sanchez-Espinosa
title	Sleep mediates the association between homocysteine and oxidative status in mild cognitive impairment
title_short	Sleep mediates the association between homocysteine and oxidative status in mild cognitive impairment
title_full	Sleep mediates the association between homocysteine and oxidative status in mild cognitive impairment
title_fullStr	Sleep mediates the association between homocysteine and oxidative status in mild cognitive impairment
title_full_unstemmed	Sleep mediates the association between homocysteine and oxidative status in mild cognitive impairment
title_sort	sleep mediates the association between homocysteine and oxidative status in mild cognitive impairment
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/dcbaa1f6c1b64db98537df177efde6b1
work_keys_str_mv	AT mayelypsanchezespinosa sleepmediatestheassociationbetweenhomocysteineandoxidativestatusinmildcognitiveimpairment AT mercedesatienza sleepmediatestheassociationbetweenhomocysteineandoxidativestatusinmildcognitiveimpairment AT joselcantero sleepmediatestheassociationbetweenhomocysteineandoxidativestatusinmildcognitiveimpairment
_version_	1718394067421757440

Sleep mediates the association between homocysteine and oxidative status in mild cognitive impairment

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