Dental Pulp Stem Cell-Derived Secretome and Its Regenerative Potential

The therapeutic potential of the dental pulp stem (DSC) cell-derived secretome, consisting of various biomolecules, is undergoing intense research. Despite promising in vitro and in vivo studies, most DSC secretome-based therapies have not been implemented in human medicine because the paracrine eff...

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Autores principales:	Julia K. Bar, Anna Lis-Nawara, Piotr Grzegorz Grelewski
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	dental stem cells secretome paracrine effect regenerative medicine Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/dcbb0e094b4a457a869f04cd392b522f
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spelling	oai:doaj.org-article:dcbb0e094b4a457a869f04cd392b522f2021-11-11T17:25:41ZDental Pulp Stem Cell-Derived Secretome and Its Regenerative Potential10.3390/ijms2221120181422-00671661-6596https://doaj.org/article/dcbb0e094b4a457a869f04cd392b522f2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/12018https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067The therapeutic potential of the dental pulp stem (DSC) cell-derived secretome, consisting of various biomolecules, is undergoing intense research. Despite promising in vitro and in vivo studies, most DSC secretome-based therapies have not been implemented in human medicine because the paracrine effect of the bioactive factors secreted by human dental pulp stem cells (hDPSCs) and human exfoliated deciduous teeth (SHEDs) is not completely understood. In this review, we outline the current data on the hDPSC- and SHED-derived secretome as a potential candidate in the regeneration of bone, cartilage, and nerve tissue. Published reports demonstrate that the dental MSC-derived secretome/conditional medium may be effective in treating neurodegenerative diseases, neural injuries, cartilage defects, and repairing bone by regulating neuroprotective, anti-inflammatory, antiapoptotic, and angiogenic processes through secretome paracrine mechanisms. Dental MSC-secretomes, similarly to the bone marrow MSC-secretome activate molecular and cellular mechanisms, which determine the effectiveness of cell-free therapy. Many reports emphasize that dental MSC-derived secretomes have potential application in tissue-regenerating therapy due to their multidirectional paracrine effect observed in the therapy of many different injured tissues.Julia K. BarAnna Lis-NawaraPiotr Grzegorz GrelewskiMDPI AGarticledental stem cellssecretomeparacrine effectregenerative medicineBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12018, p 12018 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	dental stem cells secretome paracrine effect regenerative medicine Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	dental stem cells secretome paracrine effect regenerative medicine Biology (General) QH301-705.5 Chemistry QD1-999 Julia K. Bar Anna Lis-Nawara Piotr Grzegorz Grelewski Dental Pulp Stem Cell-Derived Secretome and Its Regenerative Potential
description	The therapeutic potential of the dental pulp stem (DSC) cell-derived secretome, consisting of various biomolecules, is undergoing intense research. Despite promising in vitro and in vivo studies, most DSC secretome-based therapies have not been implemented in human medicine because the paracrine effect of the bioactive factors secreted by human dental pulp stem cells (hDPSCs) and human exfoliated deciduous teeth (SHEDs) is not completely understood. In this review, we outline the current data on the hDPSC- and SHED-derived secretome as a potential candidate in the regeneration of bone, cartilage, and nerve tissue. Published reports demonstrate that the dental MSC-derived secretome/conditional medium may be effective in treating neurodegenerative diseases, neural injuries, cartilage defects, and repairing bone by regulating neuroprotective, anti-inflammatory, antiapoptotic, and angiogenic processes through secretome paracrine mechanisms. Dental MSC-secretomes, similarly to the bone marrow MSC-secretome activate molecular and cellular mechanisms, which determine the effectiveness of cell-free therapy. Many reports emphasize that dental MSC-derived secretomes have potential application in tissue-regenerating therapy due to their multidirectional paracrine effect observed in the therapy of many different injured tissues.
format	article
author	Julia K. Bar Anna Lis-Nawara Piotr Grzegorz Grelewski
author_facet	Julia K. Bar Anna Lis-Nawara Piotr Grzegorz Grelewski
author_sort	Julia K. Bar
title	Dental Pulp Stem Cell-Derived Secretome and Its Regenerative Potential
title_short	Dental Pulp Stem Cell-Derived Secretome and Its Regenerative Potential
title_full	Dental Pulp Stem Cell-Derived Secretome and Its Regenerative Potential
title_fullStr	Dental Pulp Stem Cell-Derived Secretome and Its Regenerative Potential
title_full_unstemmed	Dental Pulp Stem Cell-Derived Secretome and Its Regenerative Potential
title_sort	dental pulp stem cell-derived secretome and its regenerative potential
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/dcbb0e094b4a457a869f04cd392b522f
work_keys_str_mv	AT juliakbar dentalpulpstemcellderivedsecretomeanditsregenerativepotential AT annalisnawara dentalpulpstemcellderivedsecretomeanditsregenerativepotential AT piotrgrzegorzgrelewski dentalpulpstemcellderivedsecretomeanditsregenerativepotential
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Dental Pulp Stem Cell-Derived Secretome and Its Regenerative Potential

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