Is the left uncinate fasciculus associated with verbal fluency decline in mild Alzheimer's disease?

The association between verbal fluency deficit in Alzheimer's disease (AD) and deterioration of specific white matter (WM) tracts is currently not well understood. Using diffusion tensor imaging, we investigated a possible association between the left uncinate fasciculus, which has been implica...

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Autores principales:	Kljajevic Vanja, Dyrba Martin, Kasper Elisabeth, Teipel Stefan
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2016
Materias:	diffusion tensor imaging (dti) mild alzheimer's disease uncinate fasciculus verbal fluency white matter Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/dcbc2fe4b0bd45f183948ae82c8763e2
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spelling	oai:doaj.org-article:dcbc2fe4b0bd45f183948ae82c8763e22021-12-05T14:11:04ZIs the left uncinate fasciculus associated with verbal fluency decline in mild Alzheimer's disease?2081-693610.1515/tnsci-2016-0014https://doaj.org/article/dcbc2fe4b0bd45f183948ae82c8763e22016-01-01T00:00:00Zhttps://doi.org/10.1515/tnsci-2016-0014https://doaj.org/toc/2081-6936The association between verbal fluency deficit in Alzheimer's disease (AD) and deterioration of specific white matter (WM) tracts is currently not well understood. Using diffusion tensor imaging, we investigated a possible association between the left uncinate fasciculus, which has been implicated in word retrieval, and verbal fluency deficit in AD. A comparison of five properties of WM (fractional anisotropy, mode of anisotropy, mean diffusivity, radial diffusivity, and axial diffusivity) in 28 mild AD patients and 26 age-, gender- and education-matched healthy controls revealed significant group differences in a range of WM tracts. Looking specifically at diffusion parameters’ values for the left uncinate fasciculus and verbal fluency scores in the AD group, we observed a positive trend between the letter fluency scores and mode of anisotropy values (r = 0.36, p = 0.55). Thus, our data suggest more global WM damage in mild AD, which also includes damage to the left uncinate fasciculus. However, damage to this particular tract is not robustly associated with verbal fluency decline at this stage of disease.Kljajevic VanjaDyrba MartinKasper ElisabethTeipel StefanDe Gruyterarticlediffusion tensor imaging (dti)mild alzheimer's diseaseuncinate fasciculusverbal fluencywhite matterNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENTranslational Neuroscience, Vol 7, Iss 1, Pp 89-91 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	diffusion tensor imaging (dti) mild alzheimer's disease uncinate fasciculus verbal fluency white matter Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	diffusion tensor imaging (dti) mild alzheimer's disease uncinate fasciculus verbal fluency white matter Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Kljajevic Vanja Dyrba Martin Kasper Elisabeth Teipel Stefan Is the left uncinate fasciculus associated with verbal fluency decline in mild Alzheimer's disease?
description	The association between verbal fluency deficit in Alzheimer's disease (AD) and deterioration of specific white matter (WM) tracts is currently not well understood. Using diffusion tensor imaging, we investigated a possible association between the left uncinate fasciculus, which has been implicated in word retrieval, and verbal fluency deficit in AD. A comparison of five properties of WM (fractional anisotropy, mode of anisotropy, mean diffusivity, radial diffusivity, and axial diffusivity) in 28 mild AD patients and 26 age-, gender- and education-matched healthy controls revealed significant group differences in a range of WM tracts. Looking specifically at diffusion parameters’ values for the left uncinate fasciculus and verbal fluency scores in the AD group, we observed a positive trend between the letter fluency scores and mode of anisotropy values (r = 0.36, p = 0.55). Thus, our data suggest more global WM damage in mild AD, which also includes damage to the left uncinate fasciculus. However, damage to this particular tract is not robustly associated with verbal fluency decline at this stage of disease.
format	article
author	Kljajevic Vanja Dyrba Martin Kasper Elisabeth Teipel Stefan
author_facet	Kljajevic Vanja Dyrba Martin Kasper Elisabeth Teipel Stefan
author_sort	Kljajevic Vanja
title	Is the left uncinate fasciculus associated with verbal fluency decline in mild Alzheimer's disease?
title_short	Is the left uncinate fasciculus associated with verbal fluency decline in mild Alzheimer's disease?
title_full	Is the left uncinate fasciculus associated with verbal fluency decline in mild Alzheimer's disease?
title_fullStr	Is the left uncinate fasciculus associated with verbal fluency decline in mild Alzheimer's disease?
title_full_unstemmed	Is the left uncinate fasciculus associated with verbal fluency decline in mild Alzheimer's disease?
title_sort	is the left uncinate fasciculus associated with verbal fluency decline in mild alzheimer's disease?
publisher	De Gruyter
publishDate	2016
url	https://doaj.org/article/dcbc2fe4b0bd45f183948ae82c8763e2
work_keys_str_mv	AT kljajevicvanja istheleftuncinatefasciculusassociatedwithverbalfluencydeclineinmildalzheimersdisease AT dyrbamartin istheleftuncinatefasciculusassociatedwithverbalfluencydeclineinmildalzheimersdisease AT kasperelisabeth istheleftuncinatefasciculusassociatedwithverbalfluencydeclineinmildalzheimersdisease AT teipelstefan istheleftuncinatefasciculusassociatedwithverbalfluencydeclineinmildalzheimersdisease
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Is the left uncinate fasciculus associated with verbal fluency decline in mild Alzheimer's disease?

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