Neutrophil-derived reactive oxygen species promote tumor colonization

Zhong et al. investigate how mutations in the NOX2 subunit Ncf1 lead to reduced ROS formation and affect B16F10 lung metastasis. The study highlights neutrophils as key to detrimental ROS-formation and suggest the involvement of IL-1 beta and RAGE.

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Detalles Bibliográficos
Autores principales: Jianghong Zhong, Qijing Li, Huqiao Luo, Rikard Holmdahl
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/dcc015fbb2bc41d0aa67b18ff8fcbeac
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Descripción
Sumario:Zhong et al. investigate how mutations in the NOX2 subunit Ncf1 lead to reduced ROS formation and affect B16F10 lung metastasis. The study highlights neutrophils as key to detrimental ROS-formation and suggest the involvement of IL-1 beta and RAGE.