In vivo assessment of reversing Cisplatin-Induced nephrotoxicity using Jatropha mollissima crude extract and its potential cytotoxicity

Jatropha mollissima is one of the ancient plants that known in Africa, Asia and Latin America for its high medicinal value. Previously we showed that the ethanolic leaves extract of J. mollissima was able to reverse the aminoglycoside antibiotics induced nephrotoxicity in only two weeks of administr...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Muhammad Omer Iqbal, Esam Bashir Yahya, Shumaila Andleeb, Muhammad Masood Ahmed, Muhammad Umar Javaid, Waleed Shakeel, Iram Iqbal
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Acute toxicity Antioxidant Jatropha mollissima Nephrotoxicity Renal function Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/dcc0f356e5094d918288a2661e86c2bd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:dcc0f356e5094d918288a2661e86c2bd
record_format	dspace
spelling	oai:doaj.org-article:dcc0f356e5094d918288a2661e86c2bd2021-11-20T04:57:13ZIn vivo assessment of reversing Cisplatin-Induced nephrotoxicity using Jatropha mollissima crude extract and its potential cytotoxicity1319-562X10.1016/j.sjbs.2021.08.057https://doaj.org/article/dcc0f356e5094d918288a2661e86c2bd2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1319562X21007452https://doaj.org/toc/1319-562XJatropha mollissima is one of the ancient plants that known in Africa, Asia and Latin America for its high medicinal value. Previously we showed that the ethanolic leaves extract of J. mollissima was able to reverse the aminoglycoside antibiotics induced nephrotoxicity in only two weeks of administration. Here, we evaluated the phytochemicals, antioxidant and in vivo cytotoxicity of the ethanolic leaves extract in addition to the ability of reversing Cisplatin-induced nephrotoxicity in wistar albino rats. The results of phytochemical analysis showed the presence of flavonoids, phenols, tannins and saponins, with significantly high antioxidant activity. The treated rats did not show any cytotoxic signs; no anatomical, physiological and/or histopathological changes compared with the control group. Kidney, spleen and liver tissues appeared normal after two weeks administration of the maximum dose, with a possible alteration in distal tubules, proximal tubules and glomerulus of the kidney tissues. The results of nephrotoxicity and kidney function suggest promising potential for J. mollissima in kidney damage treatment.Muhammad Omer IqbalEsam Bashir YahyaShumaila AndleebMuhammad Masood AhmedMuhammad Umar JavaidWaleed ShakeelIram IqbalElsevierarticleAcute toxicityAntioxidantJatropha mollissimaNephrotoxicityRenal functionBiology (General)QH301-705.5ENSaudi Journal of Biological Sciences, Vol 28, Iss 12, Pp 7373-7378 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Acute toxicity Antioxidant Jatropha mollissima Nephrotoxicity Renal function Biology (General) QH301-705.5
spellingShingle	Acute toxicity Antioxidant Jatropha mollissima Nephrotoxicity Renal function Biology (General) QH301-705.5 Muhammad Omer Iqbal Esam Bashir Yahya Shumaila Andleeb Muhammad Masood Ahmed Muhammad Umar Javaid Waleed Shakeel Iram Iqbal In vivo assessment of reversing Cisplatin-Induced nephrotoxicity using Jatropha mollissima crude extract and its potential cytotoxicity
description	Jatropha mollissima is one of the ancient plants that known in Africa, Asia and Latin America for its high medicinal value. Previously we showed that the ethanolic leaves extract of J. mollissima was able to reverse the aminoglycoside antibiotics induced nephrotoxicity in only two weeks of administration. Here, we evaluated the phytochemicals, antioxidant and in vivo cytotoxicity of the ethanolic leaves extract in addition to the ability of reversing Cisplatin-induced nephrotoxicity in wistar albino rats. The results of phytochemical analysis showed the presence of flavonoids, phenols, tannins and saponins, with significantly high antioxidant activity. The treated rats did not show any cytotoxic signs; no anatomical, physiological and/or histopathological changes compared with the control group. Kidney, spleen and liver tissues appeared normal after two weeks administration of the maximum dose, with a possible alteration in distal tubules, proximal tubules and glomerulus of the kidney tissues. The results of nephrotoxicity and kidney function suggest promising potential for J. mollissima in kidney damage treatment.
format	article
author	Muhammad Omer Iqbal Esam Bashir Yahya Shumaila Andleeb Muhammad Masood Ahmed Muhammad Umar Javaid Waleed Shakeel Iram Iqbal
author_facet	Muhammad Omer Iqbal Esam Bashir Yahya Shumaila Andleeb Muhammad Masood Ahmed Muhammad Umar Javaid Waleed Shakeel Iram Iqbal
author_sort	Muhammad Omer Iqbal
title	In vivo assessment of reversing Cisplatin-Induced nephrotoxicity using Jatropha mollissima crude extract and its potential cytotoxicity
title_short	In vivo assessment of reversing Cisplatin-Induced nephrotoxicity using Jatropha mollissima crude extract and its potential cytotoxicity
title_full	In vivo assessment of reversing Cisplatin-Induced nephrotoxicity using Jatropha mollissima crude extract and its potential cytotoxicity
title_fullStr	In vivo assessment of reversing Cisplatin-Induced nephrotoxicity using Jatropha mollissima crude extract and its potential cytotoxicity
title_full_unstemmed	In vivo assessment of reversing Cisplatin-Induced nephrotoxicity using Jatropha mollissima crude extract and its potential cytotoxicity
title_sort	in vivo assessment of reversing cisplatin-induced nephrotoxicity using jatropha mollissima crude extract and its potential cytotoxicity
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/dcc0f356e5094d918288a2661e86c2bd
work_keys_str_mv	AT muhammadomeriqbal invivoassessmentofreversingcisplatininducednephrotoxicityusingjatrophamollissimacrudeextractanditspotentialcytotoxicity AT esambashiryahya invivoassessmentofreversingcisplatininducednephrotoxicityusingjatrophamollissimacrudeextractanditspotentialcytotoxicity AT shumailaandleeb invivoassessmentofreversingcisplatininducednephrotoxicityusingjatrophamollissimacrudeextractanditspotentialcytotoxicity AT muhammadmasoodahmed invivoassessmentofreversingcisplatininducednephrotoxicityusingjatrophamollissimacrudeextractanditspotentialcytotoxicity AT muhammadumarjavaid invivoassessmentofreversingcisplatininducednephrotoxicityusingjatrophamollissimacrudeextractanditspotentialcytotoxicity AT waleedshakeel invivoassessmentofreversingcisplatininducednephrotoxicityusingjatrophamollissimacrudeextractanditspotentialcytotoxicity AT iramiqbal invivoassessmentofreversingcisplatininducednephrotoxicityusingjatrophamollissimacrudeextractanditspotentialcytotoxicity
_version_	1718419745351401472

In vivo assessment of reversing Cisplatin-Induced nephrotoxicity using Jatropha mollissima crude extract and its potential cytotoxicity

Ejemplares similares