Dose–response effects of light therapy on sleepiness and circadian phase shift in shift workers: a meta-analysis and moderator analysis

Abstract Light therapy has been considered to be effective in mitigating sleepiness and regulating circadian phase shift in shift workers. However, the effective treatment dose of light therapy remains undetermined. We performed a meta-analysis of randomized experimental studies to determine the eff...

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Autores principales:	Calvin Lam, Min-Huey Chung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dcc1d5b5562647b38ac7354a7048ea87
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spelling	oai:doaj.org-article:dcc1d5b5562647b38ac7354a7048ea872021-12-02T15:02:51ZDose–response effects of light therapy on sleepiness and circadian phase shift in shift workers: a meta-analysis and moderator analysis10.1038/s41598-021-89321-12045-2322https://doaj.org/article/dcc1d5b5562647b38ac7354a7048ea872021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89321-1https://doaj.org/toc/2045-2322Abstract Light therapy has been considered to be effective in mitigating sleepiness and regulating circadian phase shift in shift workers. However, the effective treatment dose of light therapy remains undetermined. We performed a meta-analysis of randomized experimental studies to determine the effect of light therapy doses on sleepiness and circadian phase shift in shift workers. An article search was performed in 10 electronic databases from inception to June 2020. Two raters independently screened and extracted data and reached consensus. Twenty-one eligible studies were included. Analyses were performed using random-effects models. Light therapy exerted significantly small to medium effects on sleepiness and large treatment effects on circadian phase shift. Moderator analyses performed with subgroup and metaregression analyses revealed that medium-intensity light therapy for a shorter duration more effectively reduced sleepiness at night, whereas higher-intensity light therapy more effectively induced phase shifting, but the required treatment duration remained inconclusive. This study provides evidence regarding the effect of light therapy in reducing sleepiness and shifting circadian phase in shift workers. Exposure to medium-intensity light for a short duration at night reduced sleepiness, whereas exposure to high-intensity light improved sleep by shifting their circadian phase.Calvin LamMin-Huey ChungNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Calvin Lam Min-Huey Chung Dose–response effects of light therapy on sleepiness and circadian phase shift in shift workers: a meta-analysis and moderator analysis
description	Abstract Light therapy has been considered to be effective in mitigating sleepiness and regulating circadian phase shift in shift workers. However, the effective treatment dose of light therapy remains undetermined. We performed a meta-analysis of randomized experimental studies to determine the effect of light therapy doses on sleepiness and circadian phase shift in shift workers. An article search was performed in 10 electronic databases from inception to June 2020. Two raters independently screened and extracted data and reached consensus. Twenty-one eligible studies were included. Analyses were performed using random-effects models. Light therapy exerted significantly small to medium effects on sleepiness and large treatment effects on circadian phase shift. Moderator analyses performed with subgroup and metaregression analyses revealed that medium-intensity light therapy for a shorter duration more effectively reduced sleepiness at night, whereas higher-intensity light therapy more effectively induced phase shifting, but the required treatment duration remained inconclusive. This study provides evidence regarding the effect of light therapy in reducing sleepiness and shifting circadian phase in shift workers. Exposure to medium-intensity light for a short duration at night reduced sleepiness, whereas exposure to high-intensity light improved sleep by shifting their circadian phase.
format	article
author	Calvin Lam Min-Huey Chung
author_facet	Calvin Lam Min-Huey Chung
author_sort	Calvin Lam
title	Dose–response effects of light therapy on sleepiness and circadian phase shift in shift workers: a meta-analysis and moderator analysis
title_short	Dose–response effects of light therapy on sleepiness and circadian phase shift in shift workers: a meta-analysis and moderator analysis
title_full	Dose–response effects of light therapy on sleepiness and circadian phase shift in shift workers: a meta-analysis and moderator analysis
title_fullStr	Dose–response effects of light therapy on sleepiness and circadian phase shift in shift workers: a meta-analysis and moderator analysis
title_full_unstemmed	Dose–response effects of light therapy on sleepiness and circadian phase shift in shift workers: a meta-analysis and moderator analysis
title_sort	dose–response effects of light therapy on sleepiness and circadian phase shift in shift workers: a meta-analysis and moderator analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dcc1d5b5562647b38ac7354a7048ea87
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Dose–response effects of light therapy on sleepiness and circadian phase shift in shift workers: a meta-analysis and moderator analysis

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