Fast association tests for genes with FAST.

<h4>Unlabelled</h4>Gene-based tests of association can increase the power of a genome-wide association study by aggregating multiple independent effects across a gene or locus into a single stronger signal. Recent gene-based tests have distinct approaches to selecting which variants to a...

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Autores principales:	Pritam Chanda, Hailiang Huang, Dan E Arking, Joel S Bader
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dcc3585dd4f3404b844d0650ff3f2444
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id	oai:doaj.org-article:dcc3585dd4f3404b844d0650ff3f2444
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spelling	oai:doaj.org-article:dcc3585dd4f3404b844d0650ff3f24442021-11-18T09:03:23ZFast association tests for genes with FAST.1932-620310.1371/journal.pone.0068585https://doaj.org/article/dcc3585dd4f3404b844d0650ff3f24442013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23935874/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Unlabelled</h4>Gene-based tests of association can increase the power of a genome-wide association study by aggregating multiple independent effects across a gene or locus into a single stronger signal. Recent gene-based tests have distinct approaches to selecting which variants to aggregate within a locus, modeling the effects of linkage disequilibrium, representing fractional allele counts from imputation, and managing permutation tests for p-values. Implementing these tests in a single, efficient framework has great practical value. Fast ASsociation Tests (Fast) addresses this need by implementing leading gene-based association tests together with conventional SNP-based univariate tests and providing a consolidated, easily interpreted report. Fast scales readily to genome-wide SNP data with millions of SNPs and tens of thousands of individuals, provides implementations that are orders of magnitude faster than original literature reports, and provides a unified framework for performing several gene based association tests concurrently and efficiently on the same data.<h4>Availability</h4>https://bitbucket.org/baderlab/fast/downloads/FAST.tar.gz, with documentation at https://bitbucket.org/baderlab/fast/wiki/Home.Pritam ChandaHailiang HuangDan E ArkingJoel S BaderPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 7, p e68585 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pritam Chanda Hailiang Huang Dan E Arking Joel S Bader Fast association tests for genes with FAST.
description	<h4>Unlabelled</h4>Gene-based tests of association can increase the power of a genome-wide association study by aggregating multiple independent effects across a gene or locus into a single stronger signal. Recent gene-based tests have distinct approaches to selecting which variants to aggregate within a locus, modeling the effects of linkage disequilibrium, representing fractional allele counts from imputation, and managing permutation tests for p-values. Implementing these tests in a single, efficient framework has great practical value. Fast ASsociation Tests (Fast) addresses this need by implementing leading gene-based association tests together with conventional SNP-based univariate tests and providing a consolidated, easily interpreted report. Fast scales readily to genome-wide SNP data with millions of SNPs and tens of thousands of individuals, provides implementations that are orders of magnitude faster than original literature reports, and provides a unified framework for performing several gene based association tests concurrently and efficiently on the same data.<h4>Availability</h4>https://bitbucket.org/baderlab/fast/downloads/FAST.tar.gz, with documentation at https://bitbucket.org/baderlab/fast/wiki/Home.
format	article
author	Pritam Chanda Hailiang Huang Dan E Arking Joel S Bader
author_facet	Pritam Chanda Hailiang Huang Dan E Arking Joel S Bader
author_sort	Pritam Chanda
title	Fast association tests for genes with FAST.
title_short	Fast association tests for genes with FAST.
title_full	Fast association tests for genes with FAST.
title_fullStr	Fast association tests for genes with FAST.
title_full_unstemmed	Fast association tests for genes with FAST.
title_sort	fast association tests for genes with fast.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/dcc3585dd4f3404b844d0650ff3f2444
work_keys_str_mv	AT pritamchanda fastassociationtestsforgeneswithfast AT hailianghuang fastassociationtestsforgeneswithfast AT danearking fastassociationtestsforgeneswithfast AT joelsbader fastassociationtestsforgeneswithfast
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Fast association tests for genes with FAST.

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