Spike protein of the SARS-CoV-2 virus and its relationship with the angiotensin-converting enzyme-2

Introduction: COVID-19 caused by the SARS-CoV-2 virus is a pandemic that has claimed the lives of millions of people and overloaded health services around the world. Objective: to describe the relationship between the spike protein (S) of SARS-CoV-2 and the angiotensin-converting enzyme 2 as the p...

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Autores principales:	María Teresa Díaz-Armas, Rolando Sánchez-Artigas, Tamia Zaadé Matute-Respo, Ronny Alexander Llumiquinga-Achi
Formato:	article
Lenguaje:	ES
Publicado:	Centro Editorial Ciencias Médicas: CPICM Guantánamo 2021
Materias:	covid-19 sars-cov-2 proteína de la espícula proteína s enzima convertidora de angiotensina 2 vacunas Medicine R
Acceso en línea:	https://doaj.org/article/dcc5789fb73b40f493f8b889d2c7a572
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spelling	oai:doaj.org-article:dcc5789fb73b40f493f8b889d2c7a5722021-11-03T17:26:58ZSpike protein of the SARS-CoV-2 virus and its relationship with the angiotensin-converting enzyme-21028-9933https://doaj.org/article/dcc5789fb73b40f493f8b889d2c7a5722021-10-01T00:00:00Zhttp://www.revinfcientifica.sld.cu/index.php/ric/article/view/3633https://doaj.org/toc/1028-9933Introduction: COVID-19 caused by the SARS-CoV-2 virus is a pandemic that has claimed the lives of millions of people and overloaded health services around the world. Objective: to describe the relationship between the spike protein (S) of SARS-CoV-2 and the angiotensin-converting enzyme 2 as the primary trigger of COVID-19 infection. Method: a bibliographic search was carried out in Google Scholar, SciELO and PubMed, with the initial descriptors COVID-19 and SARS-CoV-2. The publication period selected was between the years 2019 to 2021, without restrictions regarding the type of article. The papers had to be available in full text in Spanish and English. Results: the spike protein of SARS-CoV-2, which plays a key role in receptor recognition and in the cell membrane fusion process, is composed of two subunits, S1 and S2. The S1 subunit contains a receptor-binding domain (RBD) that binds to the host's receptor, angiotensin-converting enzyme 2, while the S2 subunit is involved in the viral and cellular membrane fusion. The tissue ubiquity of angiotensin converting enzyme 2 explains the multiple clinical manifestations of the disease. Conclusions: the knowledge of the relationship between SARS-CoV-2 and its receptor the angiotensin-converting enzyme 2, allows not only to know the pathophysiology of COVID-19, but also the design of antiviral drugs and vaccines that contribute to the prevention and treatment of this viral disease.María Teresa Díaz-ArmasRolando Sánchez-ArtigasTamia Zaadé Matute-RespoRonny Alexander Llumiquinga-AchiCentro Editorial Ciencias Médicas: CPICM Guantánamoarticlecovid-19sars-cov-2proteína de la espículaproteína senzima convertidora de angiotensina 2vacunasMedicineRESRevista Información Científica, Vol 100, Iss 5, Pp e3633-e3633 (2021)
institution	DOAJ
collection	DOAJ
language	ES
topic	covid-19 sars-cov-2 proteína de la espícula proteína s enzima convertidora de angiotensina 2 vacunas Medicine R
spellingShingle	covid-19 sars-cov-2 proteína de la espícula proteína s enzima convertidora de angiotensina 2 vacunas Medicine R María Teresa Díaz-Armas Rolando Sánchez-Artigas Tamia Zaadé Matute-Respo Ronny Alexander Llumiquinga-Achi Spike protein of the SARS-CoV-2 virus and its relationship with the angiotensin-converting enzyme-2
description	Introduction: COVID-19 caused by the SARS-CoV-2 virus is a pandemic that has claimed the lives of millions of people and overloaded health services around the world. Objective: to describe the relationship between the spike protein (S) of SARS-CoV-2 and the angiotensin-converting enzyme 2 as the primary trigger of COVID-19 infection. Method: a bibliographic search was carried out in Google Scholar, SciELO and PubMed, with the initial descriptors COVID-19 and SARS-CoV-2. The publication period selected was between the years 2019 to 2021, without restrictions regarding the type of article. The papers had to be available in full text in Spanish and English. Results: the spike protein of SARS-CoV-2, which plays a key role in receptor recognition and in the cell membrane fusion process, is composed of two subunits, S1 and S2. The S1 subunit contains a receptor-binding domain (RBD) that binds to the host's receptor, angiotensin-converting enzyme 2, while the S2 subunit is involved in the viral and cellular membrane fusion. The tissue ubiquity of angiotensin converting enzyme 2 explains the multiple clinical manifestations of the disease. Conclusions: the knowledge of the relationship between SARS-CoV-2 and its receptor the angiotensin-converting enzyme 2, allows not only to know the pathophysiology of COVID-19, but also the design of antiviral drugs and vaccines that contribute to the prevention and treatment of this viral disease.
format	article
author	María Teresa Díaz-Armas Rolando Sánchez-Artigas Tamia Zaadé Matute-Respo Ronny Alexander Llumiquinga-Achi
author_facet	María Teresa Díaz-Armas Rolando Sánchez-Artigas Tamia Zaadé Matute-Respo Ronny Alexander Llumiquinga-Achi
author_sort	María Teresa Díaz-Armas
title	Spike protein of the SARS-CoV-2 virus and its relationship with the angiotensin-converting enzyme-2
title_short	Spike protein of the SARS-CoV-2 virus and its relationship with the angiotensin-converting enzyme-2
title_full	Spike protein of the SARS-CoV-2 virus and its relationship with the angiotensin-converting enzyme-2
title_fullStr	Spike protein of the SARS-CoV-2 virus and its relationship with the angiotensin-converting enzyme-2
title_full_unstemmed	Spike protein of the SARS-CoV-2 virus and its relationship with the angiotensin-converting enzyme-2
title_sort	spike protein of the sars-cov-2 virus and its relationship with the angiotensin-converting enzyme-2
publisher	Centro Editorial Ciencias Médicas: CPICM Guantánamo
publishDate	2021
url	https://doaj.org/article/dcc5789fb73b40f493f8b889d2c7a572
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Spike protein of the SARS-CoV-2 virus and its relationship with the angiotensin-converting enzyme-2

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