Serum IL-6 correlates with axial mobility index (Bath Ankylosing Spondylitis Metrology Index) in Brazilian patients with ankylosing spondylitis

Cristina F Rabelo,1 Talita Siara Almeida Baptista,2 Laura Esteves Petersen,2 Moisés Evandro Bauer,2 Mauro Waldemar Keiserman,1 Henrique Luiz Staub1 1Department of Rheumatology, 2Laboratory of Immunosenescence, Institute of Biomedical Research, Pontifical Catholic University of Rio Grande...

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Autores principales:	Rabelo CF, Baptista TSA, Petersen LE, Bauer ME, Keiserman MW, Staub HL
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	ankylosing spondylitis cytokines disease activity index quality of life score. Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/dcc7ad4c01a14e06a0da21d3f135568d
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spelling	oai:doaj.org-article:dcc7ad4c01a14e06a0da21d3f135568d2021-12-02T04:32:23ZSerum IL-6 correlates with axial mobility index (Bath Ankylosing Spondylitis Metrology Index) in Brazilian patients with ankylosing spondylitis1179-156Xhttps://doaj.org/article/dcc7ad4c01a14e06a0da21d3f135568d2018-04-01T00:00:00Zhttps://www.dovepress.com/serum-il-6-correlates-to-axial-mobility-index-basmi-in-brazilian-patie-peer-reviewed-article-OARRRhttps://doaj.org/toc/1179-156XCristina F Rabelo,1 Talita Siara Almeida Baptista,2 Laura Esteves Petersen,2 Moisés Evandro Bauer,2 Mauro Waldemar Keiserman,1 Henrique Luiz Staub1 1Department of Rheumatology, 2Laboratory of Immunosenescence, Institute of Biomedical Research, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil Introduction: Ankylosing spondylitis (AS) is a chronic disease featuring axial changes, peripheral arthritis and systemic involvement. Proinflammatory cytokines are probably involved in AS pathogenesis. The relationship of circulating cytokines with instruments of AS evaluation is an open field of research.Objective: The aim of this study was to compare serum levels of cytokines in AS patients and healthy controls, and search for correlations of cytokines with indexes of disease activity and quality of life.Patients and methods: In this cross-sectional study, 32 AS patients and 32 age- and sex-matched controls were evaluated. Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Funcional Index (BASFI), Bath Ankylosing Spondylitis Metrology Index (BASMI), Ankylosing Spondylitis Disease Activity Score-C reactive protein (ASDAS-CRP), Maastricht Ankylosing Spondylitis Enthesitis Score (MASES), Ankylosing Spondylitis Quality of Life (ASQol) and Patient Global Assessment score were measured in AS patients. . The soluble cytokines IL-6, IL-8, IL-1, IL-10, TNF-α, IL-12p70 and IL-17 were quantified by flow cytometry. IL-23 concentrations were measured using an enzyme-linked immunosorbent assay.Results: Overall, AS patients were predominantly males (59.4%) and Caucasians (96.9%). Mean age was 46.9±10.7 years. Human leukocyte antigen B27 was present in 70% of cases. Concentrations of IL-6, IL-8, IL-10 and TNF-α were higher in AS cases than controls (p<0.05). Mean concentration of IL-6 correlated with the BASMI, an index of axial mobility (r=0.354, p=0.047). Anti-TNF intake (present in 21 patients, 65.6%) associated with a high BASMI (p=0.042) and lower quality of life as measured using the ASQol scale (p=0.009).Conclusion: A proinflammatory cytokine profile predominated in AS patients, but interestingly, the IL-10 concentrations were also elevated, pointing to a suppressive control of inflammation. A defined correlation of serum IL-6 with the BASMI suggests a role for this cytokine in axial disease. Anti-TNF users showed more axial activity and lower quality of life. Keywords: ankylosing spondylitis, cytokines, disease activity index, quality-of-life score, BASMIRabelo CFBaptista TSAPetersen LEBauer MEKeiserman MWStaub HLDove Medical Pressarticleankylosing spondylitiscytokinesdisease activity indexquality of life score.Diseases of the musculoskeletal systemRC925-935ENOpen Access Rheumatology: Research and Reviews, Vol Volume 10, Pp 21-25 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	ankylosing spondylitis cytokines disease activity index quality of life score. Diseases of the musculoskeletal system RC925-935
spellingShingle	ankylosing spondylitis cytokines disease activity index quality of life score. Diseases of the musculoskeletal system RC925-935 Rabelo CF Baptista TSA Petersen LE Bauer ME Keiserman MW Staub HL Serum IL-6 correlates with axial mobility index (Bath Ankylosing Spondylitis Metrology Index) in Brazilian patients with ankylosing spondylitis
description	Cristina F Rabelo,1 Talita Siara Almeida Baptista,2 Laura Esteves Petersen,2 Moisés Evandro Bauer,2 Mauro Waldemar Keiserman,1 Henrique Luiz Staub1 1Department of Rheumatology, 2Laboratory of Immunosenescence, Institute of Biomedical Research, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil Introduction: Ankylosing spondylitis (AS) is a chronic disease featuring axial changes, peripheral arthritis and systemic involvement. Proinflammatory cytokines are probably involved in AS pathogenesis. The relationship of circulating cytokines with instruments of AS evaluation is an open field of research.Objective: The aim of this study was to compare serum levels of cytokines in AS patients and healthy controls, and search for correlations of cytokines with indexes of disease activity and quality of life.Patients and methods: In this cross-sectional study, 32 AS patients and 32 age- and sex-matched controls were evaluated. Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Funcional Index (BASFI), Bath Ankylosing Spondylitis Metrology Index (BASMI), Ankylosing Spondylitis Disease Activity Score-C reactive protein (ASDAS-CRP), Maastricht Ankylosing Spondylitis Enthesitis Score (MASES), Ankylosing Spondylitis Quality of Life (ASQol) and Patient Global Assessment score were measured in AS patients. . The soluble cytokines IL-6, IL-8, IL-1, IL-10, TNF-α, IL-12p70 and IL-17 were quantified by flow cytometry. IL-23 concentrations were measured using an enzyme-linked immunosorbent assay.Results: Overall, AS patients were predominantly males (59.4%) and Caucasians (96.9%). Mean age was 46.9±10.7 years. Human leukocyte antigen B27 was present in 70% of cases. Concentrations of IL-6, IL-8, IL-10 and TNF-α were higher in AS cases than controls (p<0.05). Mean concentration of IL-6 correlated with the BASMI, an index of axial mobility (r=0.354, p=0.047). Anti-TNF intake (present in 21 patients, 65.6%) associated with a high BASMI (p=0.042) and lower quality of life as measured using the ASQol scale (p=0.009).Conclusion: A proinflammatory cytokine profile predominated in AS patients, but interestingly, the IL-10 concentrations were also elevated, pointing to a suppressive control of inflammation. A defined correlation of serum IL-6 with the BASMI suggests a role for this cytokine in axial disease. Anti-TNF users showed more axial activity and lower quality of life. Keywords: ankylosing spondylitis, cytokines, disease activity index, quality-of-life score, BASMI
format	article
author	Rabelo CF Baptista TSA Petersen LE Bauer ME Keiserman MW Staub HL
author_facet	Rabelo CF Baptista TSA Petersen LE Bauer ME Keiserman MW Staub HL
author_sort	Rabelo CF
title	Serum IL-6 correlates with axial mobility index (Bath Ankylosing Spondylitis Metrology Index) in Brazilian patients with ankylosing spondylitis
title_short	Serum IL-6 correlates with axial mobility index (Bath Ankylosing Spondylitis Metrology Index) in Brazilian patients with ankylosing spondylitis
title_full	Serum IL-6 correlates with axial mobility index (Bath Ankylosing Spondylitis Metrology Index) in Brazilian patients with ankylosing spondylitis
title_fullStr	Serum IL-6 correlates with axial mobility index (Bath Ankylosing Spondylitis Metrology Index) in Brazilian patients with ankylosing spondylitis
title_full_unstemmed	Serum IL-6 correlates with axial mobility index (Bath Ankylosing Spondylitis Metrology Index) in Brazilian patients with ankylosing spondylitis
title_sort	serum il-6 correlates with axial mobility index (bath ankylosing spondylitis metrology index) in brazilian patients with ankylosing spondylitis
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/dcc7ad4c01a14e06a0da21d3f135568d
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Serum IL-6 correlates with axial mobility index (Bath Ankylosing Spondylitis Metrology Index) in Brazilian patients with ankylosing spondylitis

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