Radiological assessment of effectiveness of soluble RAGE in attenuating Angiotensin II-induced LVH mouse model using in vivo 9.4T MRI

Abstract We investigated the effectiveness of soluble Receptor for Advanced Glycation Endproducts (sRAGE) in attenuating angiotensin II (AngII)-induced left ventricular hypertrophy (LVH) using in vivo 9.4T cine-magnetic resonance imaging (CINE-MRI). Mice were divided into four groups: AngII (n = 9),...

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Autores principales:	Dan Heo, Soyeon Lim, Jiye Lee, Myung Eun Lee, Soyoung Cho, Jisu Jeong, Miran Seo, Sungha Park, Jaemoon Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dcc8a08b2d264de6905ea6d0993616f3
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spelling	oai:doaj.org-article:dcc8a08b2d264de6905ea6d0993616f32021-12-02T15:10:04ZRadiological assessment of effectiveness of soluble RAGE in attenuating Angiotensin II-induced LVH mouse model using in vivo 9.4T MRI10.1038/s41598-019-44933-62045-2322https://doaj.org/article/dcc8a08b2d264de6905ea6d0993616f32019-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-44933-6https://doaj.org/toc/2045-2322Abstract We investigated the effectiveness of soluble Receptor for Advanced Glycation Endproducts (sRAGE) in attenuating angiotensin II (AngII)-induced left ventricular hypertrophy (LVH) using in vivo 9.4T cine-magnetic resonance imaging (CINE-MRI). Mice were divided into four groups: AngII (n = 9), saline (n = 10), sRAGE (n = 10), and AngII + sRAGE (n = 10). CINE-MRI was performed in each group after administration of the AngII or sRAGE, and CINE-MR images were analyzed to obtain parameters indicating cardiac anatomical and functional changes including end-diastolic and end-systolic blood volume, end-diastolic and end-systolic myocardial volume, ejection fraction, end-diastolic and end-systolic myocardial mass, and LV wall thickness. LVH observed in AngII group was significantly attenuated by sRAGE. These trends were also observed in histological analysis, demonstrating that cardiac function tracking using in vivo and real-time 9.4T MR imaging provides valuable information about the cardiac remodeling induced by AngII and sRAGE in an AngII-induced LV hypertrophy mice model.Dan HeoSoyeon LimJiye LeeMyung Eun LeeSoyoung ChoJisu JeongMiran SeoSungha ParkJaemoon YangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dan Heo Soyeon Lim Jiye Lee Myung Eun Lee Soyoung Cho Jisu Jeong Miran Seo Sungha Park Jaemoon Yang Radiological assessment of effectiveness of soluble RAGE in attenuating Angiotensin II-induced LVH mouse model using in vivo 9.4T MRI
description	Abstract We investigated the effectiveness of soluble Receptor for Advanced Glycation Endproducts (sRAGE) in attenuating angiotensin II (AngII)-induced left ventricular hypertrophy (LVH) using in vivo 9.4T cine-magnetic resonance imaging (CINE-MRI). Mice were divided into four groups: AngII (n = 9), saline (n = 10), sRAGE (n = 10), and AngII + sRAGE (n = 10). CINE-MRI was performed in each group after administration of the AngII or sRAGE, and CINE-MR images were analyzed to obtain parameters indicating cardiac anatomical and functional changes including end-diastolic and end-systolic blood volume, end-diastolic and end-systolic myocardial volume, ejection fraction, end-diastolic and end-systolic myocardial mass, and LV wall thickness. LVH observed in AngII group was significantly attenuated by sRAGE. These trends were also observed in histological analysis, demonstrating that cardiac function tracking using in vivo and real-time 9.4T MR imaging provides valuable information about the cardiac remodeling induced by AngII and sRAGE in an AngII-induced LV hypertrophy mice model.
format	article
author	Dan Heo Soyeon Lim Jiye Lee Myung Eun Lee Soyoung Cho Jisu Jeong Miran Seo Sungha Park Jaemoon Yang
author_facet	Dan Heo Soyeon Lim Jiye Lee Myung Eun Lee Soyoung Cho Jisu Jeong Miran Seo Sungha Park Jaemoon Yang
author_sort	Dan Heo
title	Radiological assessment of effectiveness of soluble RAGE in attenuating Angiotensin II-induced LVH mouse model using in vivo 9.4T MRI
title_short	Radiological assessment of effectiveness of soluble RAGE in attenuating Angiotensin II-induced LVH mouse model using in vivo 9.4T MRI
title_full	Radiological assessment of effectiveness of soluble RAGE in attenuating Angiotensin II-induced LVH mouse model using in vivo 9.4T MRI
title_fullStr	Radiological assessment of effectiveness of soluble RAGE in attenuating Angiotensin II-induced LVH mouse model using in vivo 9.4T MRI
title_full_unstemmed	Radiological assessment of effectiveness of soluble RAGE in attenuating Angiotensin II-induced LVH mouse model using in vivo 9.4T MRI
title_sort	radiological assessment of effectiveness of soluble rage in attenuating angiotensin ii-induced lvh mouse model using in vivo 9.4t mri
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/dcc8a08b2d264de6905ea6d0993616f3
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Radiological assessment of effectiveness of soluble RAGE in attenuating Angiotensin II-induced LVH mouse model using in vivo 9.4T MRI

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