Nasal Polyps in Children: The Early Origins of a Challenging Adulthood Condition

Nasal polyps (NPs) are benign inflammatory masses causing chronic nasal obstruction, usually associated with underlying chronic rhinosinusitis (CRS), which are rarely reported in childhood. The interest in NPs has recently increased due to new therapeutic options, namely biological agents, such as d...

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Autores principales:	Maria E. Di Cicco, Francesca Bizzoco, Elena Morelli, Veronica Seccia, Vincenzo Ragazzo, Diego G. Peroni, Pasquale Comberiati
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	adolescents asthma biologicals children chronic rhinosinusitis dupilumab Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/dcc8b2748f4a4e2b908b28f3ab3386b1
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id	oai:doaj.org-article:dcc8b2748f4a4e2b908b28f3ab3386b1
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spelling	oai:doaj.org-article:dcc8b2748f4a4e2b908b28f3ab3386b12021-11-25T17:14:22ZNasal Polyps in Children: The Early Origins of a Challenging Adulthood Condition10.3390/children81109972227-9067https://doaj.org/article/dcc8b2748f4a4e2b908b28f3ab3386b12021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9067/8/11/997https://doaj.org/toc/2227-9067Nasal polyps (NPs) are benign inflammatory masses causing chronic nasal obstruction, usually associated with underlying chronic rhinosinusitis (CRS), which are rarely reported in childhood. The interest in NPs has recently increased due to new therapeutic options, namely biological agents, such as dupilumab, and an update of the European position paper on this topic was released in 2020, providing a detailed classification for these lesions and also discussing diagnostic and therapeutic approaches also in children. In childhood, NPs usually represent red flags for systemic diseases, such as cystic fibrosis and immunodeficiencies. This review outlines the recent data on NPs in childhood, focusing on predisposing factors for CRS as well as on the potential endotypes in this particular age group, for which further studies are required in order to better clarify their pathogenesis and to identify molecular biomarkers that could help achieve more personalized treatments.Maria E. Di CiccoFrancesca BizzocoElena MorelliVeronica SecciaVincenzo RagazzoDiego G. PeroniPasquale ComberiatiMDPI AGarticleadolescentsasthmabiologicalschildrenchronic rhinosinusitisdupilumabPediatricsRJ1-570ENChildren, Vol 8, Iss 997, p 997 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	adolescents asthma biologicals children chronic rhinosinusitis dupilumab Pediatrics RJ1-570
spellingShingle	adolescents asthma biologicals children chronic rhinosinusitis dupilumab Pediatrics RJ1-570 Maria E. Di Cicco Francesca Bizzoco Elena Morelli Veronica Seccia Vincenzo Ragazzo Diego G. Peroni Pasquale Comberiati Nasal Polyps in Children: The Early Origins of a Challenging Adulthood Condition
description	Nasal polyps (NPs) are benign inflammatory masses causing chronic nasal obstruction, usually associated with underlying chronic rhinosinusitis (CRS), which are rarely reported in childhood. The interest in NPs has recently increased due to new therapeutic options, namely biological agents, such as dupilumab, and an update of the European position paper on this topic was released in 2020, providing a detailed classification for these lesions and also discussing diagnostic and therapeutic approaches also in children. In childhood, NPs usually represent red flags for systemic diseases, such as cystic fibrosis and immunodeficiencies. This review outlines the recent data on NPs in childhood, focusing on predisposing factors for CRS as well as on the potential endotypes in this particular age group, for which further studies are required in order to better clarify their pathogenesis and to identify molecular biomarkers that could help achieve more personalized treatments.
format	article
author	Maria E. Di Cicco Francesca Bizzoco Elena Morelli Veronica Seccia Vincenzo Ragazzo Diego G. Peroni Pasquale Comberiati
author_facet	Maria E. Di Cicco Francesca Bizzoco Elena Morelli Veronica Seccia Vincenzo Ragazzo Diego G. Peroni Pasquale Comberiati
author_sort	Maria E. Di Cicco
title	Nasal Polyps in Children: The Early Origins of a Challenging Adulthood Condition
title_short	Nasal Polyps in Children: The Early Origins of a Challenging Adulthood Condition
title_full	Nasal Polyps in Children: The Early Origins of a Challenging Adulthood Condition
title_fullStr	Nasal Polyps in Children: The Early Origins of a Challenging Adulthood Condition
title_full_unstemmed	Nasal Polyps in Children: The Early Origins of a Challenging Adulthood Condition
title_sort	nasal polyps in children: the early origins of a challenging adulthood condition
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/dcc8b2748f4a4e2b908b28f3ab3386b1
work_keys_str_mv	AT mariaedicicco nasalpolypsinchildrentheearlyoriginsofachallengingadulthoodcondition AT francescabizzoco nasalpolypsinchildrentheearlyoriginsofachallengingadulthoodcondition AT elenamorelli nasalpolypsinchildrentheearlyoriginsofachallengingadulthoodcondition AT veronicaseccia nasalpolypsinchildrentheearlyoriginsofachallengingadulthoodcondition AT vincenzoragazzo nasalpolypsinchildrentheearlyoriginsofachallengingadulthoodcondition AT diegogperoni nasalpolypsinchildrentheearlyoriginsofachallengingadulthoodcondition AT pasqualecomberiati nasalpolypsinchildrentheearlyoriginsofachallengingadulthoodcondition
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Nasal Polyps in Children: The Early Origins of a Challenging Adulthood Condition

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