Immunomodulatory effects of selenium‐enriched peptides from soybean in cyclophosphamide‐induced immunosuppressed mice

Abstract In this study, selenium‐enriched soybean peptides (<3 kDa, named Se‐SPep) was isolated and purified from the selenium‐enriched soybean protein (Se‐SPro) hydrolysate by ultrafiltration. The in‐vivo immunomodulatory effects of Se‐SPep were investigated in cyclophosphamide‐induced immunosup...

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Autores principales:	Jian Zhang, Siwei Gao, He Li, Mengdi Cao, Wenhui Li, Xinqi Liu
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	cyclophosphamide immunomodulatory immunosuppressed mice selenium‐enriched soybean peptides Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/dccac79beb9f4a579e7a83d95d8e056c
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spelling	oai:doaj.org-article:dccac79beb9f4a579e7a83d95d8e056c2021-11-04T13:06:43ZImmunomodulatory effects of selenium‐enriched peptides from soybean in cyclophosphamide‐induced immunosuppressed mice2048-717710.1002/fsn3.2594https://doaj.org/article/dccac79beb9f4a579e7a83d95d8e056c2021-11-01T00:00:00Zhttps://doi.org/10.1002/fsn3.2594https://doaj.org/toc/2048-7177Abstract In this study, selenium‐enriched soybean peptides (<3 kDa, named Se‐SPep) was isolated and purified from the selenium‐enriched soybean protein (Se‐SPro) hydrolysate by ultrafiltration. The in‐vivo immunomodulatory effects of Se‐SPep were investigated in cyclophosphamide‐induced immunosuppressed mice. Se‐SPep treatment could alleviate the atrophy of immune organs and weight loss observed in immunosuppressive mice. Besides, Se‐SPep administration could dramatically improve total protein, albumin, white blood cell, immunoglobulin (Ig) M, IgG, and IgA levels in blood. Moreover, Se‐SPep strongly stimulated interleukin‐2 (IL‐2), interferon‐gamma (IFN‐γ), nitric oxide (NO), and cyclic guanosine monophosphate productions by up‐regulating mRNA expressions of IL‐2, IFN‐γ, and inducible NO synthase in spleen tissue. Furthermore, Se‐SPep exhibits more effective immunomodulatory activity compared to Se‐SPro and SPep. In conclusion, Se‐SPep could effectively enhance the immune capacity of immunosuppressive mice. These findings confirm Se‐SPep is an effective immunomodulator with potential application in functional foods or dietary supplements.Jian ZhangSiwei GaoHe LiMengdi CaoWenhui LiXinqi LiuWileyarticlecyclophosphamideimmunomodulatoryimmunosuppressed miceselenium‐enriched soybean peptidesNutrition. Foods and food supplyTX341-641ENFood Science & Nutrition, Vol 9, Iss 11, Pp 6322-6334 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cyclophosphamide immunomodulatory immunosuppressed mice selenium‐enriched soybean peptides Nutrition. Foods and food supply TX341-641
spellingShingle	cyclophosphamide immunomodulatory immunosuppressed mice selenium‐enriched soybean peptides Nutrition. Foods and food supply TX341-641 Jian Zhang Siwei Gao He Li Mengdi Cao Wenhui Li Xinqi Liu Immunomodulatory effects of selenium‐enriched peptides from soybean in cyclophosphamide‐induced immunosuppressed mice
description	Abstract In this study, selenium‐enriched soybean peptides (<3 kDa, named Se‐SPep) was isolated and purified from the selenium‐enriched soybean protein (Se‐SPro) hydrolysate by ultrafiltration. The in‐vivo immunomodulatory effects of Se‐SPep were investigated in cyclophosphamide‐induced immunosuppressed mice. Se‐SPep treatment could alleviate the atrophy of immune organs and weight loss observed in immunosuppressive mice. Besides, Se‐SPep administration could dramatically improve total protein, albumin, white blood cell, immunoglobulin (Ig) M, IgG, and IgA levels in blood. Moreover, Se‐SPep strongly stimulated interleukin‐2 (IL‐2), interferon‐gamma (IFN‐γ), nitric oxide (NO), and cyclic guanosine monophosphate productions by up‐regulating mRNA expressions of IL‐2, IFN‐γ, and inducible NO synthase in spleen tissue. Furthermore, Se‐SPep exhibits more effective immunomodulatory activity compared to Se‐SPro and SPep. In conclusion, Se‐SPep could effectively enhance the immune capacity of immunosuppressive mice. These findings confirm Se‐SPep is an effective immunomodulator with potential application in functional foods or dietary supplements.
format	article
author	Jian Zhang Siwei Gao He Li Mengdi Cao Wenhui Li Xinqi Liu
author_facet	Jian Zhang Siwei Gao He Li Mengdi Cao Wenhui Li Xinqi Liu
author_sort	Jian Zhang
title	Immunomodulatory effects of selenium‐enriched peptides from soybean in cyclophosphamide‐induced immunosuppressed mice
title_short	Immunomodulatory effects of selenium‐enriched peptides from soybean in cyclophosphamide‐induced immunosuppressed mice
title_full	Immunomodulatory effects of selenium‐enriched peptides from soybean in cyclophosphamide‐induced immunosuppressed mice
title_fullStr	Immunomodulatory effects of selenium‐enriched peptides from soybean in cyclophosphamide‐induced immunosuppressed mice
title_full_unstemmed	Immunomodulatory effects of selenium‐enriched peptides from soybean in cyclophosphamide‐induced immunosuppressed mice
title_sort	immunomodulatory effects of selenium‐enriched peptides from soybean in cyclophosphamide‐induced immunosuppressed mice
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/dccac79beb9f4a579e7a83d95d8e056c
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Immunomodulatory effects of selenium‐enriched peptides from soybean in cyclophosphamide‐induced immunosuppressed mice

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