Super-resolved visualization of single DNA-based tension sensors in cell adhesion

Relatively little is known about cell-matrix interactions and the intracellular transduction of an initial ligand-receptor binding event on the single-molecule level. Here authors combine ligand-decorated DNA tension sensors with DNA-PAINT super-resolution microscopy to study the mechanical engageme...

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Autores principales:	Thomas Schlichthaerle, Caroline Lindner, Ralf Jungmann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dccd5b38be2b44af83eef1572628d143
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spelling	oai:doaj.org-article:dccd5b38be2b44af83eef1572628d1432021-12-02T14:49:22ZSuper-resolved visualization of single DNA-based tension sensors in cell adhesion10.1038/s41467-021-22606-12041-1723https://doaj.org/article/dccd5b38be2b44af83eef1572628d1432021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22606-1https://doaj.org/toc/2041-1723Relatively little is known about cell-matrix interactions and the intracellular transduction of an initial ligand-receptor binding event on the single-molecule level. Here authors combine ligand-decorated DNA tension sensors with DNA-PAINT super-resolution microscopy to study the mechanical engagement of single integrin receptors and the downstream influence on actin bundling.Thomas SchlichthaerleCaroline LindnerRalf JungmannNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Thomas Schlichthaerle Caroline Lindner Ralf Jungmann Super-resolved visualization of single DNA-based tension sensors in cell adhesion
description	Relatively little is known about cell-matrix interactions and the intracellular transduction of an initial ligand-receptor binding event on the single-molecule level. Here authors combine ligand-decorated DNA tension sensors with DNA-PAINT super-resolution microscopy to study the mechanical engagement of single integrin receptors and the downstream influence on actin bundling.
format	article
author	Thomas Schlichthaerle Caroline Lindner Ralf Jungmann
author_facet	Thomas Schlichthaerle Caroline Lindner Ralf Jungmann
author_sort	Thomas Schlichthaerle
title	Super-resolved visualization of single DNA-based tension sensors in cell adhesion
title_short	Super-resolved visualization of single DNA-based tension sensors in cell adhesion
title_full	Super-resolved visualization of single DNA-based tension sensors in cell adhesion
title_fullStr	Super-resolved visualization of single DNA-based tension sensors in cell adhesion
title_full_unstemmed	Super-resolved visualization of single DNA-based tension sensors in cell adhesion
title_sort	super-resolved visualization of single dna-based tension sensors in cell adhesion
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dccd5b38be2b44af83eef1572628d143
work_keys_str_mv	AT thomasschlichthaerle superresolvedvisualizationofsinglednabasedtensionsensorsincelladhesion AT carolinelindner superresolvedvisualizationofsinglednabasedtensionsensorsincelladhesion AT ralfjungmann superresolvedvisualizationofsinglednabasedtensionsensorsincelladhesion
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Super-resolved visualization of single DNA-based tension sensors in cell adhesion

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